Quantitative phase and absorption tomography with an X-ray grating interferometer and synchrotron radiation

We report on a study on the accuracy and precision of X-ray phase and absorption tomograms obtained with a grating interferometer using monochromatic synchrotron radiation. The quantitative assessment of the performances of the X-ray interferometer is a fundamental aspect in the interpretation of the results obtained with this device. The work presented in this paper consists in the comparison of experimental with calculated three-dimensional distributions of the X-ray refractive index in a phantom sample made of known materials. The quality of phase and absorption tomograms has been determined with respect to their sensitivity and contrast-to-noise ratios. Moreover, the effect of image artifacts typical in phase contrast imaging based on the phase-stepping technique, especially stripe features generated by the phase wrapping phenomenon, has been investigated by comparison with numerical simulations. The results show that the artifacts cannot only be qualitatively explained by the calculations, but they can even be quantitatively reproduced.

[1]  Franz Pfeiffer,et al.  Fabrication of diffraction gratings for hard X-ray phase contrast imaging , 2007 .

[2]  Franz Pfeiffer,et al.  High-resolution tomographic imaging of a human cerebellum: comparison of absorption and grating-based phase contrast , 2010, Journal of The Royal Society Interface.

[3]  Franz Pfeiffer,et al.  Quantitative phase-contrast tomography of a liquid phantom using a conventional x-ray tube source. , 2009, Optics express.

[4]  Atsushi Momose,et al.  Demonstration of X-Ray Talbot Interferometry , 2003 .

[5]  Franz Pfeiffer,et al.  X-ray phase imaging with a grating interferometer. , 2005, Optics express.

[6]  D. C. Ghiglia IFSAR correlation improvement through local slope correction , 1998, IGARSS '98. Sensing and Managing the Environment. 1998 IEEE International Geoscience and Remote Sensing. Symposium Proceedings. (Cat. No.98CH36174).

[7]  A Bravin,et al.  High-resolution brain tumor visualization using three-dimensional x-ray phase contrast tomography , 2007, Physics in medicine and biology.

[8]  A. Momose Recent Advances in X-ray Phase Imaging , 2005 .

[9]  C. David,et al.  Differential x-ray phase contrast imaging using a shearing interferometer , 2002 .

[10]  Richard J. Fitzgerald,et al.  Phase‐Sensitive X‐Ray Imaging , 2000 .

[11]  Juergen Mohr,et al.  Soft X-ray lithography of high aspect ratio SU8 submicron structures , 2008 .

[12]  Manuel Sanchez del Rio,et al.  Status of XOP: an x-ray optics software toolkit , 2004, SPIE Optics + Photonics.

[13]  Guang-Hong Chen,et al.  Radiation dose efficiency comparison between differential phase contrast CT and conventional absorption CT. , 2010, Medical physics.

[14]  O. Bunk,et al.  Phase retrieval and differential phase-contrast imaging with low-brilliance X-ray sources , 2006 .

[15]  Arne Tapfer,et al.  Recent developments in x-ray Talbot interferometry at ESRF-ID19 , 2010, Optical Engineering + Applications.