Internationalization of biotechnology start-ups: Geographic location and mimetic behaviour

The objective of this article is to understand the extent to which location in a geographic cluster can explain international alliance formation. Geographic clusters are characterized by several dimensions: agglomeration economies, institutional forces and a manager’s mental models create the environment within the cluster. Therefore, to develop the research propositions, which were tested on a sample of US biotechnology start-ups, the study specifically analysed cluster size and firm competitive behaviour within the cluster to explain the propensity of a start-up to engage in new international alliances. It also examined the potential moderating effect of cluster evolution. Results show that merely being located in a geographic cluster in itself does not increase the probability of forming a new international alliance. Within clusters, internationalization of start-ups through alliance formation results mainly from mimetic behaviour.

[1]  M. Feldman,et al.  Knowledge spillovers and the geography of innovation , 2004 .

[2]  W. Powell,et al.  THE IRON CAGE REVISITED: , 1983, The New Economic Sociology.

[3]  M. Feldman The Entrepreneurial Event Revisited: Firm Formation in a Regional Context , 2001 .

[4]  R. Pouder,et al.  Hot Spots and Blind Spots: Geographical Clusters of Firms and Innovation , 1996 .

[5]  M. Berry,et al.  Multinationals in a New Era , 2001 .

[6]  Geoffrey G. Bell Clusters, networks, and firm innovativeness , 2005 .

[7]  L. Piscitello,et al.  Localized capabilities and the internationalization of manufacturing activities by SMEs , 2001 .

[8]  Frank T. Rothaermel,et al.  Technological discontinuities and interfirm cooperation: what determines a startup's attractiveness as alliance partner? , 2002, IEEE Trans. Engineering Management.

[9]  Julian Birkinshaw,et al.  WHY DO SOME MULTINATIONAL CORPORATIONS RELOCATE THEIR HEADQUARTERS OVERSEAS , 2006 .

[10]  Jim Bell,et al.  Industrial Clusters and Small Firm Internationalisation (Best paper) , 2001 .

[11]  M. Antonio,et al.  Internationalization and Performance: findings from a set of Italian SMEs , 2001 .

[12]  Heather A. Haveman Organizational size and change: Diversification in the savings and loan industry after deregulation , 1993 .

[13]  R. Narula,et al.  Innovating through strategic alliances: moving towards international partnerships and contractual agreements , 1999 .

[14]  Manuela Presutti,et al.  Industrial clusters, entrepreneurial culture and the social environment: The effects on FDI distribution , 2009 .

[15]  W. Powell,et al.  The iron cage revisited institutional isomorphism and collective rationality in organizational fields , 1983 .

[16]  Stuart R. Borrett,et al.  Structure of pathways in ecological networks: relationships between length and number , 2003 .

[17]  Stephanie A. Fernhaber,et al.  International entrepreneurship and geographic location: an empirical examination of new venture internationalization , 2008 .

[18]  R. Burt Social Contagion and Innovation: Cohesion versus Structural Equivalence , 1987, American Journal of Sociology.

[19]  P. Zwart,et al.  Alliance Formation Motives in SMEs , 2009 .

[20]  Lori Rosenkopf,et al.  INSTITUTIONAL AND COMPETITIVE BANDWAGONS: USING MATHEMATICAL MODELING AS A TOOL TO EXPLORE INNOVATION DIFFUSION , 1993 .

[21]  B. Kogut,et al.  Interfirm cooperation and startup innovation in the biotechnology industry , 1994 .

[22]  David L. Deeds,et al.  An examination of the investments in U.S. biotechnology firms by foreign and domestic corporate partners , 2006 .

[23]  B. Kogut,et al.  Localization of Knowledge and the Mobility of Engineers in Regional Networks , 1999 .

[24]  Nitin Pangarkar,et al.  Bandwagon Pressures and Interfirm Alliances in the Global Pharmaceutical Industry , 1998 .

[25]  J. Hagedoorn Understanding the rationale of strategic technology partnering: Nterorganizational modes of cooperation and sectoral differences , 1993 .

[26]  M. Feldman,et al.  R&D spillovers and the ge-ography of innovation and production , 1996 .

[27]  Pino G. Audia,et al.  Close, but not the same: Locally headquartered organizations and agglomeration economies in a declining industry , 2010 .

[28]  Sabahat Bayrak Kök,et al.  Internationalization and Alliance Formation , 2009 .

[29]  Peter Maskell,et al.  Towards a Knowledge‐based Theory of the Geographical Cluster , 2001 .

[30]  J. McCall,et al.  Agglomeration economies, search costs, and industrial location , 1980 .

[31]  Alfred Marshall,et al.  Industry and Trade , 2003 .

[32]  Martha Prevezer,et al.  The Dynamics of Industrial Clustering in Biotechnology , 1997 .

[33]  P. P. McDougall,et al.  Toward a theory of international new ventures , 1994 .

[34]  Harbir Singh,et al.  The Effect of National Culture on the Choice of Entry Mode , 1988 .

[35]  H. Greve Managerial Cognition and the Mimetic Adoption of Market Positions: What You See is What You Do , 1998 .

[36]  M. Porter The Competitive Advantage Of Nations , 1990 .

[37]  A. Mamman,et al.  Contradictions in international tertiary strategic alliances: the case from down under , 2000 .

[38]  P. Cooke Regional Innovation Systems, Clusters, and the Knowledge Economy , 2001 .

[39]  Timothy B. Folta,et al.  Geographic cluster size and firm performance , 2006 .

[40]  Karin Fladmoe-Lindquist,et al.  Breakthrough innovations in the U.S. biotechnology industry: the effects of technological space and geographic origin , 2006 .

[41]  David L. Deeds,et al.  DYNAMIC CAPABILITIES AND NEW PRODUCT DEVELOPMENT IN HIGH TECHNOLOGY VENTURES: AN EMPIRICAL ANALYSIS OF NEW BIOTECHNOLOGY FIRMS , 2000 .

[42]  Vangelis Souitaris,et al.  Network embeddedness and new-venture internationalization: Analyzing international linkages in the German biotech industry , 2008 .

[43]  Joel A. C. Baum,et al.  Don't go it alone: alliance network composition and startups' performance in Canadian biotechnology , 2000 .

[44]  Nitin Nohria,et al.  Local Versus Global Mimetism: The Dynamics of Alliance Formation in the Automobile Industry , 2002 .

[45]  S. Zyglidopoulos,et al.  The internationalization journey of a high‐tech cluster , 2005 .

[46]  Janell D. Townsend,et al.  Mimetic and experiential effects in international marketing alliance formations of US pharmaceuticals firms: An event history analysis , 2009 .

[47]  G. Knight,et al.  Innovation, organizational capabilities, and the born-global firm , 2004 .

[48]  Fredrick Flyer,et al.  Agglomeration economies, firm heterogeneity, and foreign direct investment in the United States , 2000 .

[49]  Paul W. Beamish,et al.  The internationalization and performance of SMEs , 2001 .

[50]  Xiao-Ping Zheng Determinants of agglomeration economies and diseconomies:: empirical evidence from Tokyo , 2001 .

[51]  Lucia Piscitello,et al.  The Internationalization of Production by Italian Industrial Districts' Firms: Structural and Behavioural Determinants , 2008 .

[52]  A. Chandler,et al.  Regional Advantage: Culture and Competition in Silicon Valley and Route 128 , 1994 .

[53]  Udo Staber,et al.  Imitation without Interaction: How Firms Identify with Clusters , 2010 .

[54]  Xianggui Qu,et al.  Multivariate Data Analysis , 2007, Technometrics.

[55]  Varghese P. George,et al.  Reach out or reach within? Performance implications of alliances and location in biotechnology , 2004 .

[56]  Stephen Tallman,et al.  Knowledge, clusters, and competitive advantage , 2004 .

[57]  N. Arranz,et al.  Internationalization Process of Spanish Small Firms , 2009 .

[58]  J. Birkinshaw,et al.  Characteristics of Foreign Subsidiaries in Industry Clusters , 2000 .

[59]  Jan W. Rivkin,et al.  Activity Systems as Barriers to Imitation , 1998 .

[60]  Kenneth W. Koput,et al.  The Spatial Clustering of Science and Capital: Accounting for Biotech Firm-Venture Capital Relationships , 2002 .

[61]  J. Cortright,et al.  Signs of life: The growth of biotechnology centers in the U.S , 2002 .

[62]  Kathryn Walsh,et al.  Interfirm Cooperation among Small Manufacturing Firms , 2008 .

[63]  Allen J. Scott,et al.  New Industrial Spaces: Flexible Production Organization and Regional Development in North America and Western Europe , 1989 .

[64]  M. Hannan,et al.  The Population Ecology of Organizations , 1977, American Journal of Sociology.

[65]  Raphaël Suire,et al.  The ambivalent role of mimetic behaviors in proximity dynamics , 2005 .