Blockade of ARHGAP11A reverses malignant progress via inactivating Rac1B in hepatocellular carcinoma

[1]  A. Bishayee,et al.  Matrix Metalloproteinases: A challenging paradigm of cancer management. , 2017, Seminars in cancer biology.

[2]  C. Der,et al.  Filling GAPs in our knowledge: ARHGAP11A and RACGAP1 act as oncogenes in basal-like breast cancers , 2018, Small GTPases.

[3]  M. Hung,et al.  Actin cytoskeleton remodeling drives epithelial‐mesenchymal transition for hepatoma invasion and metastasis in mice , 2018, Hepatology.

[4]  Changzhao Li,et al.  Testes-specific protease 50 (TSP50) promotes invasion and metastasis by inducing EMT in gastric cancer , 2018, BMC Cancer.

[5]  D. Witte,et al.  Negative regulation of TGF-β1-induced MKK6-p38 and MEK-ERK signalling and epithelial-mesenchymal transition by Rac1b , 2017, Scientific Reports.

[6]  Tao Xi,et al.  The CCR2 3′UTR functions as a competing endogenous RNA to inhibit breast cancer metastasis , 2017, Journal of Cell Science.

[7]  Wei Liu,et al.  Tg737 regulates epithelial-mesenchymal transition and cancer stem cell properties via a negative feedback circuit between Snail and HNF4α during liver stem cell malignant transformation. , 2017, Cancer letters.

[8]  Xin Liu,et al.  MicroRNA-1291 promotes endometrial fibrosis by regulating the ArhGAP29-RhoA/ROCK1 signaling pathway in a murine model , 2017, Molecular medicine reports.

[9]  Nan Li,et al.  The noncoding RNA HOXD-AS1 is a critical regulator of the metastasis and apoptosis phenotype in human hepatocellular carcinoma , 2017, Molecular Cancer.

[10]  R. Hass,et al.  TGF-β-Dependent Growth Arrest and Cell Migration in Benign and Malignant Breast Epithelial Cells Are Antagonistically Controlled by Rac1 and Rac1b , 2017, International journal of molecular sciences.

[11]  Da-dao Jing,et al.  Serine protease inhibitor Kazal type 1 (SPINK1) downregulates E‐cadherin and induces EMT of hepatoma cells to promote hepatocellular carcinoma metastasis via the MEK/ERK signaling pathway , 2017, Journal of digestive diseases.

[12]  W. Hong,et al.  ETS (E26 transformation-specific) up-regulation of the transcriptional co-activator TAZ promotes cell migration and metastasis in prostate cancer , 2017, The Journal of Biological Chemistry.

[13]  Bing Wang,et al.  PTIP promotes recurrence and metastasis of hepatocellular carcinoma by regulating epithelial-mesenchymal transition , 2017, Oncotarget.

[14]  Gaosi Xu,et al.  ARHGAP24 inhibits cell cycle progression, induces apoptosis and suppresses invasion in renal cell carcinoma , 2016, Oncotarget.

[15]  Nicole M. Baker,et al.  Rho GTPase Transcriptome Analysis Reveals Oncogenic Roles for Rho GTPase-Activating Proteins in Basal-like Breast Cancers. , 2016, Cancer research.

[16]  Tao Xi,et al.  STARD13-correlated ceRNA network inhibits EMT and metastasis of breast cancer , 2016, Oncotarget.

[17]  N. Luo,et al.  ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells , 2016, Cell Death and Disease.

[18]  Ming Zhou,et al.  SH3-domain binding protein 1 in the tumor microenvironment promotes hepatocellular carcinoma metastasis through WAVE2 pathway , 2016, Oncotarget.

[19]  K. Hui,et al.  EDIL3 is a novel regulator of epithelial-mesenchymal transition controlling early recurrence of hepatocellular carcinoma. , 2015, Journal of hepatology.

[20]  Yuning Zhou,et al.  Rich1 negatively regulates the epithelial cell cycle, proliferation and adhesion by CDC42/RAC1-PAK1-Erk1/2 pathway. , 2015, Cellular signalling.

[21]  A. Maker,et al.  Essential roles of FoxM1 in Ras-induced liver cancer progression and in cancer cells with stem cell features. , 2015, Journal of hepatology.

[22]  A. Jemal,et al.  Global cancer statistics, 2012 , 2015, CA: a cancer journal for clinicians.

[23]  D. Radisky,et al.  Regulation of Epithelial-Mesenchymal Transition in Breast Cancer Cells by Cell Contact and Adhesion , 2015, Cancer informatics.

[24]  K. Mimori,et al.  Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo , 2013, PloS one.

[25]  D. Radisky,et al.  Extracellular matrix proteins regulate epithelial-mesenchymal transition in mammary epithelial cells. , 2013, Differentiation; research in biological diversity.

[26]  Xiaolin Zhou,et al.  RhoGAPs attenuate cell proliferation by direct interaction with p53 tetramerization domain. , 2013, Cell reports.

[27]  E. Ligeti,et al.  In silico tissue-distribution of human Rho family GTPase activating proteins , 2013, Small GTPases.

[28]  S. Licciulli,et al.  The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis , 2012, Oncogene.

[29]  D. Radisky,et al.  Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression , 2012, Science Translational Medicine.

[30]  B. Bapat,et al.  Rac1b recruits Dishevelled and β-catenin to Wnt target gene promoters independent of Wnt3A stimulation. , 2011, International journal of oncology.

[31]  A. Jemal,et al.  Global Cancer Statistics , 2011 .

[32]  Stephanie Roessler,et al.  A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. , 2010, Cancer research.

[33]  Hideki Yamamoto,et al.  Wnt5a regulates distinct signalling pathways by binding to Frizzled2 , 2010, The EMBO journal.

[34]  K. Hahn,et al.  DLC‐1 suppresses non‐small cell lung cancer growth and invasion by RhoGAP‐dependent and independent mechanisms , 2008, Molecular carcinogenesis.

[35]  B. Bapat,et al.  Activation of tumor-specific splice variant Rac1b by dishevelled promotes canonical Wnt signaling and decreased adhesion of colorectal cancer cells. , 2007, Cancer research.

[36]  G. Christofori New signals from the invasive front , 2006, Nature.

[37]  D. Albertson,et al.  Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability , 2005, Nature.

[38]  P. Jordan,et al.  Expression of Rac1b stimulates NF-kappaB-mediated cell survival and G1/S progression. , 2005, Experimental cell research.

[39]  E. Lengyel,et al.  Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation , 2004, Oncogene.

[40]  B. Bapat,et al.  Cross-talk between Rac1 GTPase and dysregulated Wnt signaling pathway leads to cellular redistribution of β-catenin and TCF/LEF-mediated transcriptional activation , 2004, Oncogene.

[41]  A. Ridley Rho Proteins and Cancer , 2004, Breast Cancer Research and Treatment.

[42]  John G. Collard,et al.  Tumor-related Alternatively Spliced Rac1b Is Not Regulated by Rho-GDP Dissociation Inhibitors and Exhibits Selective Downstream Signaling* , 2003, Journal of Biological Chemistry.

[43]  P. Jordan,et al.  Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors , 1999, Oncogene.

[44]  A. Jemal,et al.  Global cancer statistics , 2011, CA: a cancer journal for clinicians.