Edge Enhancement Nucleus and Cytoplast Contour Detector of Cervical Smear Images

This paper presents an edge enhancement nucleus and cytoplast contour (EENCC) detector to enable cutting the nucleus and cytoplast from a cervical smear cell image. To clean up noises from an image, this paper proposes a trim-meaning filter that can effectively remove impulse and Gaussian noises but still preserves the sharpness of object boundaries. In addition, a bigroup enhancer is proposed to make a clear-cut separation of the pixels lying in-between two objects. A mean vector difference enhancer is presented to suppress the gradients of noises and also to brighten the gradients of object contours. What is more, a relative-distance-error measure is put forward to evaluate the segmentation error between the extracted and target object contours. The experimental results show that all the aforementioned techniques proposed have performed impressively. Other than for cervical smear images, these proposed techniques can also be utilized in object segmentation of other images.

[1]  A. Lacy,et al.  Near real time confocal microscopy of amelanotic tissue: detection of dysplasia in ex-vivo cervical tissue , 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

[2]  Junaed Sattar Snakes , Shapes and Gradient Vector Flow , 2022 .

[3]  Lijun Yin,et al.  Scalable edge enhancement with automatic optimization for digital radiographic images , 2004, Pattern Recognit..

[4]  Tatsuya Yoshida,et al.  A Novel Method of Virtual Histopathology Using Laser-Scanning Confocal Microscopy In-Vitro with Untreated Fresh Specimens from the Gastrointestinal Mucosa , 2000, Endoscopy.

[5]  M. Rajadhyaksha,et al.  Confocal scanning laser microscopy of benign and malignant melanocytic skin lesions in vivo. , 2001, Journal of the American Academy of Dermatology.

[6]  Jonas Norup Classification of Pap-smear data by tranduction neuro-fuzzy methods , 2005 .

[7]  John F. Canny,et al.  A Computational Approach to Edge Detection , 1986, IEEE Transactions on Pattern Analysis and Machine Intelligence.

[8]  Bülent Sankur,et al.  Survey over image thresholding techniques and quantitative performance evaluation , 2004, J. Electronic Imaging.

[9]  Ross Francis Walker Adaptive multi-scale texture analysis : with application to automated cytology , 1997 .

[10]  Mohd Yusoff Mashor,et al.  Seeded Region Growing Features Extraction Algorithm; Its Potential Use in Improving Screening for Cervical Cancer , 2005 .

[11]  A F Gmitro,et al.  Rapid observation of unfixed, unstained human skin biopsy specimens with confocal microscopy and visualization. , 1997, Journal of biomedical optics.

[12]  Haisang Wu,et al.  Optimal segmentation of cell images , 1998 .

[13]  Brian C. Lovell,et al.  A methodology for quality control in cell nucleus segmentation , 1999 .

[14]  Richard A. Domanik,et al.  Segmentation of nuclear images in automated cervical cancer screening , 1995, Optical Engineering Midwest.

[15]  R. Webb,et al.  In vivo confocal scanning laser microscopy of human skin II: advances in instrumentation and comparison with histology. , 1999, The Journal of investigative dermatology.

[16]  W. Frable,et al.  Needle Aspiration Biopsy of Pulmonary Tumors , 1982 .

[17]  E. R. Davies,et al.  Machine vision - theory, algorithms, practicalities , 2004 .

[18]  P. Corcuff,et al.  In vivo confocal microscopy of human skin: a new design for cosmetology and dermatology. , 2006, Scanning.

[19]  N. Otsu A threshold selection method from gray level histograms , 1979 .

[20]  F. Russo,et al.  Color edge detection in presence of gaussian noise using nonlinear pre-filtering , 2003, Proceedings of the 20th IEEE Instrumentation Technology Conference (Cat. No.03CH37412).

[21]  Fabrizio Russo,et al.  Color edge detection in presence of Gaussian noise using nonlinear prefiltering , 2005, IEEE Transactions on Instrumentation and Measurement.

[22]  Rebecca R. Richards-Kortum,et al.  An image model and segmentation algorithm for reflectance confocal images of in vivo cervical tissue , 2005, IEEE Transactions on Image Processing.

[23]  E. Martin Pap-Smear Classification , 2003 .

[24]  R. Webb,et al.  In vivo confocal scanning laser microscopy of human skin: melanin provides strong contrast. , 1995, The Journal of investigative dermatology.

[25]  A. Halpern,et al.  Detection of clinically amelanotic malignant melanoma and assessment of its margins by in vivo confocal scanning laser microscopy. , 2001, Archives of dermatology.