Current progress towards the metabolic engineering of plant seed oil for hydroxy fatty acids production

[1]  D. I. Givens,et al.  Fatty Acid Composition , 2016 .

[2]  Chris Somerville,et al.  Next generation biofuels , 2015 .

[3]  Chaofu Lu,et al.  A fatty acid condensing enzyme from Physaria fendleri increases hydroxy fatty acid accumulation in transgenic oilseeds of Camelina sativa , 2014, Planta.

[4]  Sean R. Johnson,et al.  Fatty acid synthesis is inhibited by inefficient utilization of unusual fatty acids for glycerolipid assembly , 2014, Proceedings of the National Academy of Sciences.

[5]  A. Green,et al.  Plant Acyl-CoA:Lysophosphatidylcholine Acyltransferases (LPCATs) Have Different Specificities in Their Forward and Reverse Reactions , 2013, The Journal of Biological Chemistry.

[6]  José María Arroyo-Caro,et al.  Molecular Characterization of a Lysophosphatidylcholine Acyltransferase Gene Belonging to the MBOAT Family in Ricinus communis L. , 2013, Lipids.

[7]  José María Arroyo-Caro,et al.  The multigene family of lysophosphatidate acyltransferase (LPAT)-related enzymes in Ricinus communis: cloning and molecular characterization of two LPAT genes that are expressed in castor seeds. , 2013, Plant science : an international journal of experimental plant biology.

[8]  J. Ohlrogge,et al.  Acyl-Lipid Metabolism , 2013, The arabidopsis book.

[9]  R. Weselake,et al.  Metabolic Interactions between the Lands Cycle and the Kennedy Pathway of Glycerolipid Synthesis in Arabidopsis Developing Seeds[W] , 2012, Plant Cell.

[10]  Chaofu Lu,et al.  Acyl Editing and Headgroup Exchange Are the Major Mechanisms That Direct Polyunsaturated Fatty Acid Flux into Triacylglycerols1[W][OA] , 2012, Plant Physiology.

[11]  J. Browse,et al.  The Significance of Different Diacylgycerol Synthesis Pathways on Plant Oil Composition and Bioengineering , 2012, Front. Plant Sci..

[12]  R. Haslam,et al.  Feedback regulation of plastidic acetyl-CoA carboxylase by 18:1-acyl carrier protein in Brassica napus , 2012, Proceedings of the National Academy of Sciences.

[13]  R. Holič,et al.  Engineered high content of ricinoleic acid in fission yeast Schizosaccharomyces pombe , 2012, Applied Microbiology and Biotechnology.

[14]  Chaofu Lu,et al.  The Phosphatidylcholine Diacylglycerol Cholinephosphotransferase Is Required for Efficient Hydroxy Fatty Acid Accumulation in Transgenic Arabidopsis1[W][OA] , 2012, Plant Physiology.

[15]  E. Mietkiewska,et al.  Identification and characterization of an LCAT‐like Arabidopsis thaliana gene encoding a novel phospholipase A , 2012, FEBS letters.

[16]  D. Swarbreck,et al.  Tissue-Specific Whole Transcriptome Sequencing in Castor, Directed at Understanding Triacylglycerol Lipid Biosynthetic Pathways , 2012, PloS one.

[17]  D. Taylor,et al.  Triacylglycerol synthesis by PDAT1 in the absence of DGAT1 activity is dependent on re-acylation of LPC by LPCAT2 , 2012, BMC Plant Biology.

[18]  Runzhi Li,et al.  Vernonia DGATs can complement the disrupted oil and protein metabolism in epoxygenase-expressing soybean seeds. , 2012, Metabolic engineering.

[19]  J. Ohlrogge,et al.  Compartmentation of Triacylglycerol Accumulation in Plants* , 2011, The Journal of Biological Chemistry.

[20]  J. Browse,et al.  The pathway of triacylglycerol synthesis through phosphatidylcholine in Arabidopsis produces a bottleneck for the accumulation of unusual fatty acids in transgenic seeds. , 2011, The Plant journal : for cell and molecular biology.

[21]  Markus Pauly,et al.  Comparative deep transcriptional profiling of four developing oilseeds , 2011, The Plant journal : for cell and molecular biology.

[22]  M. A. Foster,et al.  Lesquerella: New crop development and commercialization in the U.S. , 2011 .

[23]  P. Fairley Introduction: Next generation biofuels , 2011, Nature.

[24]  M. Suh,et al.  Endoplasmic reticulum-located PDAT1-2 from castor bean enhances hydroxy fatty acid accumulation in transgenic plants. , 2011, Plant & cell physiology.

[25]  D. Andrews,et al.  Hydrophobic‐Domain‐Dependent Protein–Protein Interactions Mediate the Localization of GPAT Enzymes to ER Subdomains , 2011, Traffic.

[26]  Grace Q Chen,et al.  Effective Reduction of Chimeric Tissue in Transgenics for the Stable Genetic Transformation of Lesquerella fendleri , 2011 .

[27]  J. Browse,et al.  Castor Phospholipid:Diacylglycerol Acyltransferase Facilitates Efficient Metabolism of Hydroxy Fatty Acids in Transgenic Arabidopsis1[W][OA] , 2010, Plant Physiology.

[28]  V. Katavić,et al.  Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis. , 2010, The Plant journal : for cell and molecular biology.

[29]  C. Kemfert,et al.  An overview of biofuel policies across the world , 2010 .

[30]  J. Ohlrogge,et al.  A distinct type of glycerol-3-phosphate acyltransferase with sn-2 preference and phosphatase activity producing 2-monoacylglycerol , 2010, Proceedings of the National Academy of Sciences.

[31]  B. Sunderland,et al.  Western Australian sandalwood seed oil: new opportunities , 2010 .

[32]  I. Young,et al.  Lipid metabolism. , 2002, Current opinion in lipidology.

[33]  Chaofu Lu,et al.  An enzyme regulating triacylglycerol composition is encoded by the ROD1 gene of Arabidopsis , 2009, Proceedings of the National Academy of Sciences.

[34]  Ayhan Demirbas,et al.  Political, economic and environmental impacts of biofuels: A review , 2009 .

[35]  J. Shockey,et al.  Arabidopsis thaliana GPAT8 and GPAT9 are localized to the ER and possess distinct ER retrieval signals: functional divergence of the dilysine ER retrieval motif in plant cells. , 2009, Plant physiology and biochemistry : PPB.

[36]  R. Weselake,et al.  A 10-kDa acyl-CoA-binding protein (ACBP) from Brassica napus enhances acyl exchange between acyl-CoA and phosphatidylcholine. , 2009, Plant biotechnology journal.

[37]  Jürgen O. Metzger,et al.  FATS AND OILS AS RENEWABLE FEEDSTOCK FOR CHEMISTRY , 2009 .

[38]  D. Kosma,et al.  Arabidopsis CER8 encodes LONG-CHAIN ACYL-COA SYNTHETASE 1 (LACS1) that has overlapping functions with LACS2 in plant wax and cutin synthesis. , 2009, The Plant journal : for cell and molecular biology.

[39]  M. Chye,et al.  An Arabidopsis family of six acyl-CoA-binding proteins has three cytosolic members. , 2009, Plant physiology and biochemistry : PPB.

[40]  Chien-Yu Huang,et al.  Oil Bodies and Oleosins in Physcomitrella Possess Characteristics Representative of Early Trends in Evolution1[W][OA] , 2009, Plant Physiology.

[41]  M. Lakshminarayana,et al.  Expression of the cry1EC gene in castor (Ricinus communis L.) confers field resistance to tobacco caterpillar (Spodoptera litura Fabr) and castor semilooper (Achoea janata L.) , 2009, Plant Cell Reports.

[42]  J. Ohlrogge,et al.  Analysis of Acyl Fluxes through Multiple Pathways of Triacylglycerol Synthesis in Developing Soybean Embryos1[W][OA] , 2009, Plant Physiology.

[43]  T. Isbell,et al.  Fatty acid profile of Lesquerella germplasm in the National Plant Germplasm System collection. , 2009 .

[44]  J. Ohlrogge,et al.  Characterization of two Arabidopsis thaliana acyltransferases with preference for lysophosphatidylethanolamine , 2009, BMC Plant Biology.

[45]  D. Taylor,et al.  Increase in nervonic acid content in transformed yeast and transgenic plants by introduction of a Lunaria annua L. 3-ketoacyl-CoA synthase (KCS) gene , 2009, Plant Molecular Biology.

[46]  Chaofu Lu,et al.  Metabolic engineering of hydroxy fatty acid production in plants: RcDGAT2 drives dramatic increases in ricinoleate levels in seed oil. , 2008, Plant biotechnology journal.

[47]  T. Isbell,et al.  Method for analysis of fatty acid distribution and oil content on a single Lesquerella fendleri seed , 2008 .

[48]  M. Sujatha,et al.  Stable genetic transformation of castor (Ricinus communis L.) via particle gun-mediated gene transfer using embryo axes from mature seeds , 2008, Plant Cell Reports.

[49]  X. Qiu,et al.  An Oleate Hydroxylase from the Fungus Claviceps purpurea: Cloning, Functional Analysis, and Expression in Arabidopsis[OA] , 2008, Plant Physiology.

[50]  Shirong Zhang,et al.  A phenylalanine in DGAT is a key determinant of oil content and composition in maize , 2008, Nature Genetics.

[51]  Chaofu Lu,et al.  Generation of transgenic plants of a potential oilseed crop Camelina sativa by Agrobacterium-mediated transformation , 2008, Plant Cell Reports.

[52]  J. Ohlrogge,et al.  Identification of acyltransferases required for cutin biosynthesis and production of cutin with suberin-like monomers , 2007, Proceedings of the National Academy of Sciences.

[53]  Mark A. Smith,et al.  A FAD2 homologue from Lesquerella lindheimeri has predominantly fatty acid hydroxylase activity , 2007 .

[54]  佐仲 雅樹,et al.  胃排出 feedback regulation 機構における男女差 , 2007 .

[55]  J. Ohlrogge,et al.  The Acyltransferase GPAT5 Is Required for the Synthesis of Suberin in Seed Coat and Root of Arabidopsis[W][OA] , 2007, The Plant Cell Online.

[56]  J. Browse,et al.  A mutation in Arabidopsis cytochrome b5 reductase identified by high-throughput screening differentially affects hydroxylation and desaturation. , 2006, The Plant journal : for cell and molecular biology.

[57]  J. Kroon,et al.  Identification and functional expression of a type 2 acyl-CoA:diacylglycerol acyltransferase (DGAT2) in developing castor bean seeds which has high homology to the major triglyceride biosynthetic enzyme of fungi and animals. , 2006, Phytochemistry.

[58]  J. Shockey,et al.  Tung Tree DGAT1 and DGAT2 Have Nonredundant Functions in Triacylglycerol Biosynthesis and Are Localized to Different Subdomains of the Endoplasmic Reticulum[W] , 2006, The Plant Cell Online.

[59]  A. Kinney,et al.  Conjugated fatty acids accumulate to high levels in phospholipids of metabolically engineered soybean and Arabidopsis seeds. , 2006, Phytochemistry.

[60]  Chaofu Lu,et al.  A high-throughput screen for genes from castor that boost hydroxy fatty acid accumulation in seed oils of transgenic Arabidopsis. , 2006, The Plant journal : for cell and molecular biology.

[61]  J. Ohlrogge,et al.  Studies on biosynthesis of waxes by developing jojoba seed tissue , 1978, Lipids.

[62]  B. Malathi,et al.  Agrobacterium-mediated genetic transformation and production of semilooper resistant transgenic castor (Ricinus communis L.) , 2006, Euphytica.

[63]  A. Enikeev,et al.  Physiological Effects of Rapeseed Transformation with the acb Gene as Affected by the Genetic Vector Structure , 2005, Russian Journal of Plant Physiology.

[64]  H. U. Kim,et al.  Ubiquitous and Endoplasmic Reticulum–Located Lysophosphatidyl Acyltransferase, LPAT2, Is Essential for Female but Not Male Gametophyte Development in Arabidopsis , 2005, The Plant Cell Online.

[65]  M. Sujatha,et al.  Stable genetic transformation of castor (Ricinus communis L.) via Agrobacterium tumefaciens-mediated gene transfer using embryo axes from mature seeds , 2005, Plant Cell Reports.

[66]  Edgar B Cahoon,et al.  Dimorphecolic Acid Is Synthesized by the Coordinate Activities of Two Divergent Δ12-Oleic Acid Desaturases* , 2004, Journal of Biological Chemistry.

[67]  J. Browse,et al.  The Acyl-CoA Synthetase Encoded by LACS2 Is Essential for Normal Cuticle Development in Arabidopsis , 2004, The Plant Cell Online.

[68]  Y. Poirier,et al.  Impact of Unusual Fatty Acid Synthesis on Futile Cycling through β-Oxidation and on Gene Expression in Transgenic Plants1[w] , 2004, Plant Physiology.

[69]  Mark A. Smith,et al.  Expression of the FAE1 gene and FAE1 promoter activity in developing seeds of Arabidopsis thaliana , 2001, Plant Molecular Biology.

[70]  S. Stymne,et al.  Desaturation of oxygenated fatty acids in Lesquerella and other oil seeds , 2004, Planta.

[71]  I. Nishida,et al.  The gene and the RNA for the precursor to the plastid-located glycerol-3-phosphate acyltransferase of Arabidopsis thaliana , 2004, Plant Molecular Biology.

[72]  Qun Xia,et al.  Arabidopsis AtGPAT1, a Member of the Membrane-Bound Glycerol-3-Phosphate Acyltransferase Gene Family, Is Essential for Tapetum Differentiation and Male Fertility Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.012427. , 2003, The Plant Cell Online.

[73]  Edgar B Cahoon,et al.  Fungal responsive fatty acid acetylenases occur widely in evolutionarily distant plant families. , 2003, The Plant journal : for cell and molecular biology.

[74]  C. Turner,et al.  Identification and Quantification of the Molecular Species of Acylglycerols in Castor Oil by HPLC Using ELSD , 2003 .

[75]  Mark A. Smith,et al.  Heterologous expression of a fatty acid hydroxylase gene in developing seeds of Arabidopsis thaliana , 2003, Planta.

[76]  R. Mullen,et al.  Molecular Analysis of a Bifunctional Fatty Acid Conjugase/Desaturase from Tung. Implications for the Evolution of Plant Fatty Acid Diversity1 , 2002, Plant Physiology.

[77]  Frank D. Gunstone,et al.  Vegetable Oils in Food Technology: Composition, Properties, and Uses , 2002 .

[78]  J. Shockey,et al.  Two long-chain acyl-CoA synthetases from Arabidopsis thaliana involved in peroxisomal fatty acid beta-oxidation. , 2002, The Plant journal : for cell and molecular biology.

[79]  M. Ramadan,et al.  Oil composition of coriander (Coriandrum sativum L.) fruit-seeds , 2002 .

[80]  J. Browse,et al.  Fatty Acid Export from the Chloroplast. Molecular Characterization of a Major Plastidial Acyl-Coenzyme A Synthetase from Arabidopsis1 , 2002, Plant Physiology.

[81]  J. Browse,et al.  Arabidopsis Contains Nine Long-Chain Acyl-Coenzyme A Synthetase Genes That Participate in Fatty Acid and Glycerolipid Metabolism1 , 2002, Plant Physiology.

[82]  J. Ohlrogge,et al.  Carbocyclic fatty acids in plants: Biochemical and molecular genetic characterization of cyclopropane fatty acid synthesis of Sterculia foetida , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[83]  Ibrahim Amri The Lauric (Coconut and Palm Kernel) Oils , 2002 .

[84]  L. Kunst,et al.  A condensing enzyme from the seeds of Lesquerella fendleri that specifically elongates hydroxy fatty acids. , 2001, Plant physiology.

[85]  T. Voelker,et al.  DGAT2 Is a New Diacylglycerol Acyltransferase Gene Family , 2001, The Journal of Biological Chemistry.

[86]  P. Covello,et al.  Seed-specific over-expression of an Arabidopsis cDNA encoding a diacylglycerol acyltransferase enhances seed oil content and seed weight. , 2001, Plant physiology.

[87]  A. Green,et al.  Transgenic expression of a Δ12-epoxygenase gene in Arabidopsis seeds inhibits accumulation of linoleic acid , 2001, Planta.

[88]  D. Dierig,et al.  Registration of WCL‐LY2 High Oil Lesquerella fendleri Germplasm , 2001 .

[89]  A. Kinney,et al.  Formation of Conjugated Δ8,Δ10-Double Bonds by Δ12-Oleic-acid Desaturase-related Enzymes , 2001, The Journal of Biological Chemistry.

[90]  S. Stymne,et al.  The involvement of phospholipid:diacylglycerol acyltransferases in triacylglycerol production. , 2000, Biochemical Society transactions.

[91]  S. Stymne,et al.  Phospholipid:diacylglycerol acyltransferase: an enzyme that catalyzes the acyl-CoA-independent formation of triacylglycerol in yeast and plants. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[92]  L. Kunst,et al.  All fatty acids are not equal: discrimination in plant membrane lipids. , 2000, Trends in plant science.

[93]  A. Kinney,et al.  Biosynthetic origin of conjugated double bonds: production of fatty acid components of high-value drying oils in transgenic soybean embryos. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[94]  A. Kumar,et al.  The Arabidopsis thaliana TAG1 mutant has a mutation in a diacylglycerol acyltransferase gene. , 1999, The Plant journal : for cell and molecular biology.

[95]  John Shanklin,et al.  DESATURATION AND RELATED MODIFICATIONS OF FATTY ACIDS1. , 1998, Annual review of plant physiology and plant molecular biology.

[96]  M. Bafor,et al.  Identification of non-heme diiron proteins that catalyze triple bond and epoxy group formation. , 1998, Science.

[97]  M. Frentzen Acyltransferases from basic science to modified seed oils , 1998 .

[98]  J. Ohlrogge,et al.  Expression of Lauroyl–Acyl Carrier Protein Thioesterase in Brassica napus Seeds Induces Pathways for Both Fatty Acid Oxidation and Biosynthesis and Implies a Set Point for Triacylglycerol Accumulation , 1998, Plant Cell.

[99]  S. Boddupalli,et al.  A bifunctional oleate 12-hydroxylase: desaturase from Lesquerella fendleri. , 1998, The Plant journal : for cell and molecular biology.

[100]  P. Covello,et al.  Metabolism of Hydroxy Fatty Acids in Developing Seeds in the Genera Lesquerella (Brassicaceae) and Linum (Linaceae) , 1997, Plant physiology.

[101]  P. Broun,et al.  Accumulation of Ricinoleic, Lesquerolic, and Densipolic Acids in Seeds of Transgenic Arabidopsis Plants That Express a Fatty Acyl Hydroxylase cDNA from Castor Bean , 1997, Plant physiology.

[102]  Frank D. Gunstone,et al.  Lipid technologies and applications , 1997 .

[103]  D. Hayes,et al.  A detailed triglyceride analysis ofLesquerella fendleri oil: Column chromatographic fractionation followed by supercritical fluid chromatography , 1996 .

[104]  P. Broun,et al.  An oleate 12-hydroxylase from Ricinus communis L. is a fatty acyl desaturase homolog. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[105]  J. Ohlrogge,et al.  Feedback inhibition of fatty acid synthesis in tobacco suspension cells , 1995 .

[106]  S. Stymne,et al.  Plant Microsomal Phospholipid Acyl Hydrolases Have Selectivities for Uncommon Fatty Acids , 1995, Plant physiology.

[107]  R. Dewey,et al.  The AAPT1 gene of soybean complements a cholinephosphotransferase-deficient mutant of yeast. , 1994, The Plant cell.

[108]  K. Feldmann,et al.  Arabidopsis FAD2 gene encodes the enzyme that is essential for polyunsaturated lipid synthesis. , 1994, The Plant cell.

[109]  F. S. Nakayama,et al.  Lesquerella commercialization efforts in the United States , 1992 .

[110]  S. Stymne,et al.  Plant microsomal phospholipases exhibit preference for phosphatidylcholine with oxygenated acyl groups , 1992 .

[111]  M. Bafor,et al.  Ricinoleic acid biosynthesis and triacylglycerol assembly in microsomal preparations from developing castor-bean (Ricinus communis) endosperm. , 1991, The Biochemical journal.

[112]  J. Simon,et al.  Chemistry of new industrial oilseed crops. , 1990 .

[113]  S. Fujii,et al.  Diacylglycerol acyltransferase in maturing safflower seeds: its influences on the fatty acid composition of triacylglycerol and on the rate of triacylglycerol synthesis. , 1988, Biochimica et biophysica acta.

[114]  S. Gardiner,et al.  Some properties of cholinephosphotransferase from developing safflower cotyledons , 1985 .

[115]  S. Stymne,et al.  Evidence for the reversibility of the acyl-CoA:lysophosphatidylcholine acyltransferase in microsomal preparations from developing safflower (Carthamus tinctorius L.) cotyledons and rat liver. , 1984, The Biochemical journal.

[116]  L. Princen,et al.  Development of new crops for industrial raw materials , 1984 .

[117]  J. Browse,et al.  Some evidence for the reversibility of the cholinephosphotransferasecatalysed reaction in developing linseed cotyledons in vivo , 1983 .

[118]  R. Moreau,et al.  Recent studies of the enzymic synthesis of ricinoleic Acid by developing castor beans. , 1981, Plant physiology.

[119]  R. C. Badami,et al.  Structure and occurrence of unusual fatty acids in minor seed oils. , 1980, Progress in lipid research.

[120]  L. J. Nisbet,et al.  Differentiation of Claviceps purpurea in axenic culture. , 1976, Journal of general microbiology.

[121]  C. R. Smith Occurrence of unusual fatty acids in plants , 1971 .

[122]  P. Stumpf,et al.  Fat metabolism in higher plants. XXXV. Partial primary structure of spinach acyl carrier protein. , 1968, Archives of biochemistry and biophysics.

[123]  P. Stumpf,et al.  Fat metabolism in higher plants. 30. Enzymatic synthesis of ricinoleic acid by a microsomal preparation from developing Ricinus communis seeds. , 1966, The Journal of biological chemistry.

[124]  E. H. Melvin,et al.  Dimorphecolic Acid—A Unique Hydroxydienoid Fatty Acid2 , 1960 .

[125]  E. P. Kennedy,et al.  The enzymatic synthesis of triglycerides. , 1956, The Journal of biological chemistry.

[126]  B. Jacobson,et al.  Fat Metabolism in Higher Plants , 1959 .