Sterigmatocystin in foodstuffs and feed: aspects to consider

ABSTRACT Sterigmatocystin (STC) is a possible human carcinogen (2B) according to International Agency for Research on Cancer classification and has been associated with immunotoxic and immunomodulatory activity, together with mutagenic effects. It might be found in numerous substrates, from foods and feeds to chronically damp building materials and indoor dust. Although European Food Safety Authority concluded that the exposure to STC to be of low concern for public health, reinforces the need of data concerning exposure of European citizens. Climate change can represent an increased risk of exposure to STC since it is a crucial factor for agro-ecosystem powering fungal colonisation and mycotoxin production This aspect can represent an increased risk for European countries with temperate climates and it was already reported by the scientific community.

[1]  A. Gomes,et al.  Fungal contamination in green coffee beans samples: A public health concern , 2017, Journal of toxicology and environmental health. Part A.

[2]  N. Guizani,et al.  Illumina MiSeq sequencing analysis of fungal diversity in stored dates , 2017, BMC Microbiology.

[3]  M. Romani,et al.  Sterigmatocystin Occurrence in Paddy and Processed Rice Produced in Italy in the Years 2014–2015 and Distribution in Milled Rice Fractions , 2017, Toxins.

[4]  Z. Mašková,et al.  THE OCCURRENCE OF MICROMYCETES IN APPLES AND THEIR POTENTIAL ABILITY TO PRODUCE MYCOTOXINS , 2017 .

[5]  H. J. Fels-Klerx,et al.  Modelling climate change impacts on mycotoxin contamination , 2016 .

[6]  H. Mol,et al.  Strategies for estimating human exposure to mycotoxins via food , 2016 .

[7]  J. Frisvad,et al.  A reappraisal of Aspergillus section Nidulantes with descriptions of two new sterigmatocystin-producing species , 2016, Plant Systematics and Evolution.

[8]  J. Frisvad,et al.  Aspergillus section Nidulantes (formerly Emericella): Polyphasic taxonomy, chemistry and biology , 2016, Studies in mycology.

[9]  W. Darwish,et al.  Mould contamination and aflatoxin residues in frozen chicken meat-cuts and giblets , 2016 .

[10]  S. Kocsubé,et al.  New sterigmatocystin-producing species of Aspergillus section Versicolores from indoor air in Croatia , 2016, Mycological Progress.

[11]  E. Piecková.  Domestic Environment: Indoor Mycobiota As a Public Health Risk Factor , 2016 .

[12]  Xianghong Zhang,et al.  Sterigmatocystin-induced checkpoint adaptation depends on Chk1 in immortalized human gastric epithelial cells in vitro , 2016, Archives of Toxicology.

[13]  S. Viegas,et al.  Environmental Mycology in Public Health - Fungi and Mycotoxins: Risk Assessment and Management , 2015 .

[14]  R. Krska,et al.  Presence of Multiple Mycotoxins and Other Fungal Metabolites in Native Grasses from a Wetland Ecosystem in Argentina Intended for Grazing Cattle , 2015, Toxins.

[15]  R. Krska,et al.  Fungal and bacterial metabolites associated with natural contamination of locally processed rice (Oryza sativa L.) in Nigeria , 2015, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[16]  C. Anagnostopoulos,et al.  Survey on sterigmatocystin in food , 2015 .

[17]  Carla Viegas,et al.  Assessment of workers' exposure to aflatoxin B1 in a Portuguese waste industry. , 2015, The Annals of occupational hygiene.

[18]  Wei Gao,et al.  Sterigmatocystin-induced oxidative DNA damage in human liver-derived cell line through lysosomal damage. , 2015, Toxicology in vitro : an international journal published in association with BIBRA.

[19]  J. Barcelo,et al.  Fungal and mycotoxin contamination of coffee beans in Benguet province, Philippines , 2015, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[20]  V. Hubka,et al.  Revision of Aspergillus section Flavipedes: seven new species and proposal of section Jani sect. nov. , 2015, Mycologia.

[21]  J. Frisvad,et al.  Taxonomy , chemodiversity , and chemoconsistency of Aspergillus , Penicillium , and Talaromyces species Frisvad , 2017 .

[22]  Xianghong Zhang,et al.  Sterigmatocystin induces G1 arrest in primary human esophageal epithelial cells but induces G2 arrest in immortalized cells: key mechanistic differences in these two models , 2015, Archives of Toxicology.

[23]  Yang Liu,et al.  Proapoptotic activity of aflatoxin B1 and sterigmatocystin in HepG2 cells , 2014, Toxicology reports.

[24]  P. Njobeh,et al.  Isolation of Filamentous Fungi Species Contaminating Some Nigerian Food Commodities , 2014 .

[25]  J. Varga,et al.  Phylogeny, identification and nomenclature of the genus Aspergillus , 2014, Studies in mycology.

[26]  K. Seifert,et al.  Aspergillus, Penicillium and Talaromyces isolated from house dust samples collected around the world , 2014, Studies in mycology.

[27]  Xianghong Zhang,et al.  Impairment of cell cycle progression by sterigmatocystin in human pulmonary cells in vitro. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[28]  S. Fiori,et al.  Fungal and aflatoxin contamination of marketed spices , 2014 .

[29]  J. D. Jong,et al.  Occurence of mycotoxins and pesticides in straw and hay used as animal feed , 2014 .

[30]  R. D. de Vries,et al.  Modern taxonomy of biotechnologically important Aspergillus and Penicillium species. , 2014, Advances in applied microbiology.

[31]  W. Buzina,et al.  Identification and quantification of fungi and mycotoxins from Pu-erh tea. , 2013, International journal of food microbiology.

[32]  A. E. Abidi,et al.  First survey on the presence of ochratoxin A and fungi in raw cereals and peanut available in the Republic of Niger , 2013 .

[33]  L. Cavaglieri,et al.  Mycobiota and mycotoxins present in finished fish feeds from farms in the Rio de Janeiro State, Brazil , 2013, International Aquatic Research.

[34]  Ž. Jurjević,et al.  Sterigmatocystin production by nine newly described Aspergillus species in section Versicolores grown on two different media , 2013, Mycotoxin Research.

[35]  H. Knutsen,et al.  Scientific Opinion on the risk for public and animal health related to the presence of sterigmatocystin in food and feed , 2013 .

[36]  S. Viegas,et al.  Occupational exposure to toxigenic Aspergilius versicolor in Portuguese swines. , 2013 .

[37]  M. Piotrowska.  Contamination of breakfast cereal products by fungi and mycotoxins - a potential risk for consumer's health , 2013 .

[38]  R. Sabino,et al.  Occupational Exposure to Aspergillus by Swine and Poultry Farm Workers in Portugal , 2012, Journal of toxicology and environmental health. Part A.

[39]  Rudolf Krska,et al.  Quantitation of mycotoxins in food and feed from Burkina Faso and Mozambique using a modern LC-MS/MS multitoxin method. , 2012, Journal of agricultural and food chemistry.

[40]  M. Kačániová,et al.  Microscopic fungi recovered from honey and their toxinogenity , 2012, Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.

[41]  M. Al-Seeni.  Natural occurrence of heavy metal, fungi and mycotoxins in soybean meal samples used in animal feeding in Saudi Arabia , 2012 .

[42]  L. Xing,et al.  Effects of sterigmatocystin on TNF-α, IL-6 and IL-12 expression in murine peripheral blood mononuclear cells and peritoneal macrophages in vivo. , 2012, Molecular medicine reports.

[43]  John L. Spouge,et al.  Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for Fungi , 2012, Proceedings of the National Academy of Sciences.

[44]  V. Bartkevičs,et al.  Stability of sterigmatocystin during the bread making process and its occurrence in bread from the Latvian market , 2012, Mycotoxin Research.

[45]  Yanfei Jia,et al.  Expression of immunoglobulin-like transcript (ILT)2 and ILT3 in human gastric cancer and its clinical significance , 2012, Molecular medicine reports.

[46]  N. A. Soldatenko,et al.  More accurate determination of the minimum allowable level of sterigmatocystin in piglet feed , 2011, Russian Agricultural Sciences.

[47]  N. Lima,et al.  Further mycotoxin effects from climate change , 2011 .

[48]  íková,et al.  Respiratory toxicity of Aspergillus versicolor: the most common indoor mould in Slovakia. , 2011 .

[49]  A. Aydin,et al.  Mycotoxin levels and incidence of mould in Turkish rice , 2011, Environmental monitoring and assessment.

[50]  F. Cabañes,et al.  Effect of water activity, temperature and incubation time on growth and ochratoxin A production by Aspergillus niger and Aspergillus carbonarius on maize kernels. , 2011, International journal of food microbiology.

[51]  J. Frisvad,et al.  The mycobiota of three dry-cured meat products from Slovenia. , 2011, Food microbiology.

[52]  J. Frisvad,et al.  Distribution of sterigmatocystin in filamentous fungi. , 2011, Fungal biology.

[53]  C. Tabuc,et al.  Survey of moulds and mycotoxin contamination of cereals in South-Eastern Romania in 2008-2010. , 2011 .

[54]  A. Ayalew.  Mycotoxins and surface and internal fungi of maize from Ethiopia , 2010 .

[55]  Al-Hazmi.  Determination of zearalenone (ZEA) in wheat samples collected from Jeddah market, Saudi Arabia , 2010 .

[56]  Mi Ae Kim,et al.  Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor , 2010, Archives of pharmacal research.

[57]  S. T. Anjorin,et al.  Fungal and aflatoxin contamination of some human food commodities in Nigeria , 2010 .

[58]  J. Miller,et al.  Inflammation-associated gene transcription and expression in mouse lungs induced by low molecular weight compounds from fungi from the built environment. , 2010, Chemico-biological interactions.

[59]  Piero Toscano,et al.  Modelling, predicting and mapping the emergence of aflatoxins in cereals in the EU due to climate change , 2010 .

[60]  D. Pejin,et al.  Occurrence of potentially toxigenic mould species in fresh salads of different kinds of ready-for-use vegetables , 2010 .

[61]  C. Tabuc,et al.  INCIDENCE OF ASPERGILLUS STRAINS AND OF AFLATOXIN B 1 IN CEREALS IN SOUTH-WESTERN ROMANIA , 2010 .

[62]  R. Labuda,et al.  Fungi on wheat bran and their toxinogenity. , 2009, Annals of agricultural and environmental medicine : AAEM.

[63]  G. Chemining’wa,et al.  The occurrence of aflatoxins in maize and distribution of mycotoxin-producing fungi in Eastern Kenya. , 2009 .

[64]  P. Guerre,et al.  Molds and mycotoxin content of cereals in southeastern Romania. , 2009, Journal of food protection.

[65]  C. V. Van Peteghem,et al.  Determination of sterigmatocystin in cheese by high-performance liquid chromatography-tandem mass spectrometry , 2009, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[66]  A. S. Halstensen.  Species-specific Fungal DNA in Airborne Dust as Surrogate for Occupational Mycotoxin Exposure? , 2008, International journal of molecular sciences.

[67]  V. Bartkevičs,et al.  Sterigmatocystin presence in typical Latvian grains. , 2008, Food chemistry.

[68]  R. Pachauri.  Climate change 2007. Synthesis report. Contribution of Working Groups I, II and III to the fourth assessment report , 2008 .

[69]  S. Saeger,et al.  Determination of sterigmatocystin in beer by high performance liquid chromatography with ultraviolet detection , 2008 .

[70]  L. Cavaglieri,et al.  Mycobiota and naturally-occurring ochratoxin A in dairy cattle feed from Rio de Janeiro State, Brazil , 2008 .

[71]  Robert M. Williams,et al.  Isolation, structure elucidation, and biomimetic total synthesis of versicolamide B, and the isolation of antipodal (-)-stephacidin A and (+)-notoamide B from Aspergillus versicolor NRRL 35600. , 2008, Angewandte Chemie.

[72]  M. Youssef,et al.  Mycobiota and Mycotoxins of Egyptian Peanut (Arachis hypogeae L.) Seeds , 2008 .

[73]  A. Riba,et al.  Mycoflora and ochratoxin A producing strains of Aspergillus in Algerian wheat. , 2008, International journal of food microbiology.

[74]  C. Magnoli,et al.  The mycoflora and toxicity of feedstuffs from a production plant in córdoba, Argentina , 2002, Mycotoxin Research.

[75]  J. Gloer,et al.  Kipukasins, nucleoside derivatives from Aspergillus versicolor. , 2007, Journal of natural products.

[76]  R. Labuda,et al.  Fungi recovered from Slovakian poultry feed mixtures and their toxinogenity. , 2006, Annals of agricultural and environmental medicine : AAEM.

[77]  Xianghong Zhang,et al.  [Effects of sterigmatocystin on HLA- I expression of human peripheral blood mononuclear cells in vitro]. , 2005, Wei sheng yan jiu = Journal of hygiene research.

[78]  K. Mahrous,et al.  Adsorption of sterigmatocystin by montmorillonite and inhibition of its genotoxicity in the Nile tilapia fish (Oreachromis nilaticus). , 2005, Mutation research.

[79]  A. El-Shanawany,et al.  Fungal populations and mycotoxins in silage in Assiut and Sohag governorates in Egypt, with a special reference to characteristic Aspergilli toxins , 2005, Mycopathologia.

[80]  F. Accensi,et al.  Occurrence of Aspergillus species in mixed feeds and component raw materials and their ability to produce ochratoxin A , 2004 .

[81]  Jürgen Bünger,et al.  Cytotoxicity of occupationally and environmentally relevant mycotoxins. , 2004, Toxicology.

[82]  John E. Linz,et al.  Clustered Pathway Genes in Aflatoxin Biosynthesis , 2004, Applied and Environmental Microbiology.

[83]  Naresh Magan,et al.  Post-Harvest Fungal Ecology: Impact of Fungal Growth and Mycotoxin Accumulation in Stored Grain , 2003, European Journal of Plant Pathology.

[84]  S. Alghalibi,et al.  MYCOFLORA AND MYCOTOXIN CONTAMINATION OF SOME DRIED FRUITS IN YEMEN REPUBLIC , 2004 .

[85]  A. Wheals,et al.  Toxigenic fungi associated with processed (green) coffee beans (Coffea arabica L.). , 2003, International journal of food microbiology.

[86]  N. M. Hassanein,et al.  Mycotoxin production in wheat grains by different Aspergilli in relation to different relative humidities and storage periods. , 2003, Die Nahrung.

[87]  Xianghong Zhang,et al.  [Effects of sterigmatocystin on interleukin-2 secretion of human peripheral blood mononuclear cells in vitro]. , 2002, Wei sheng yan jiu = Journal of hygiene research.

[88]  H. Devaraj,et al.  Lipid peroxidation as a possible secondary mechanism of sterigmatocystin toxicity , 2001, Human & experimental toxicology.

[89]  T. Xie,et al.  Absence of p53-mediated G1 arrest with induction of MDM2 in sterigmatocystin-treated cells. , 2000, International journal of oncology.

[90]  C. Pozzi,et al.  Mycoflora and occurrence of aflatoxin B(1) and fumonisin B(1) during storage of Brazilian sorghum. , 2000, Journal of agricultural and food chemistry.

[91]  P. Dilkin,et al.  Mycoflora and aflatoxigenic species in derivatives of milled rice , 2000 .

[92]  M. Peraica,et al.  Toxic effects of mycotoxins in humans. , 1999, Bulletin of the World Health Organization.

[93]  N. Keller,et al.  Aspergillus nidulans stcP encodes an O-methyltransferase that is required for sterigmatocystin biosynthesis , 1996, Applied and environmental microbiology.

[94]  M. Sekijima,et al.  Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells. , 1995, Natural toxins.

[95]  J. Miller,et al.  Mycotoxins in grain: compounds other than aflatoxin. , 1994 .

[96]  Garner Rc,et al.  DNA adducts of aflatoxins, sterigmatocystin and other mycotoxins. , 1994 .

[97]  R. Garner,et al.  DNA adducts of aflatoxins, sterigmatocystin and other mycotoxins. , 1994, IARC scientific publications.

[98]  S. Ellard,et al.  Micronucleus assays using cytochalasin-blocked MCL-5 cells, a proprietary human cell line expressing five human cytochromes P-450 and microsomal epoxide hydrolase. , 1993, Mutagenesis.

[99]  N. Yoshimi,et al.  Genotoxic effects of a variety of sterigmatocystin-related compounds in the hepatocyte/DNA-repair test and the Salmonella microsome assay. , 1986, Mutation research.

[100]  C. Townsend.  Progress toward a biosynthetic rationale of the aflatoxin pathway , 1986 .

[101]  M. V. Reddy,et al.  Formation and persistence of sterigmatocystin--DNA adducts in rat liver determined via 32P-postlabeling analysis. , 1985, Mutation research.

[102]  G. Sullivan,et al.  Sex and Age Differences in the Distribution of 14C-Sterigmatocystin in Immature and Mature Rats: A Multiple Dose Study , 1985 .

[103]  Y. Nozawa,et al.  Inhibitory effect of sterigmatocystin and 5,6-dimethoxysterigmatocystin on ATP synthesis in mitochondria , 1984, Applied and environmental microbiology.

[104]  R. Reed,et al.  Induction of sister-chromatid exchanges in vivo in mice by the mycotoxins sterigmatocystin and griseofulvin. , 1984, Mutation research.

[105]  S. Chattopadhyay,et al.  Acute cytogenetic effect of sterigmatocystin on rat bone-marrow cells in vivo. , 1984, Mutation research.

[106]  J. Essigmann,et al.  Use of the isolated perfused rat liver to study carcinogen-DNA adduct formation from aflatoxin B1 and sterigmatocystin. , 1980, Cancer research.

[107]  J. Essigmann,et al.  Sterigmatocystin-DNA interactions: identification of a major adduct formed after metabolic activation in vitro. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[108]  I. Purchase,et al.  Acute toxicity of sterigmatocystin to rats. , 1969, Food and cosmetics toxicology.

[109]  K. Raper,et al.  The genus Aspergillus , 1966 .

[110]  in the Presence of Multiple , 2022 .