Future acceptance of adolescent human papillomavirus vaccination: a survey of parental attitudes.

The main target group for vaccination against human papillomavirus (HPV), the sexually transmitted virus that causes cervical cancer, will be young adolescents. We undertook a population-based survey to assess parental consent and potential HPV vaccine uptake in eight secondary schools using stratified randomisation according to school type and ethnicity. Our results suggest that in socially and ethnically mixed populations such as Manchester, an HPV vaccine uptake rate of 80% may be achievable if the vaccine is perceived to be safe and effective. However, most parents lack knowledge about HPV and some are concerned about sexual health issues that would arise as part of a HPV vaccine programme. It will be important to raise general awareness of the role of HPV in cervical cancer without stigmatizing the vaccine.

[1]  Daron G Ferris,et al.  Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial , 2004, The Lancet.

[2]  J. Fortenberry,et al.  HIV immunization: acceptability and anticipated effects on sexual behavior among adolescents. , 1999, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[3]  Margaret T Keane,et al.  Confidence in vaccination: a parent model. , 2005, Vaccine.

[4]  W. Cassidy School-based adolescent hepatitis B immunization programs in the United States: strategies and successes. , 1998, The Pediatric infectious disease journal.

[5]  T. Davis,et al.  Childhood immunization refusal: provider and parent perceptions. , 2004, Family medicine.

[6]  J. Wardle,et al.  Making sense of information about HPV in cervical screening: a qualitative study , 2005, British Journal of Cancer.

[7]  D. Ferris,et al.  Human Papillomavirus Vaccine Acceptability Among Parents of 10- to 15-Year-Old Adolescents , 2004, Journal of lower genital tract disease.

[8]  A. Middleman Race/ethnicity and gender disparities in the utilization of a school-based hepatitis B immunization initiative. , 2004, The Journal of adolescent health : official publication of the Society for Adolescent Medicine.

[9]  D. Bernstein,et al.  Attitudes about human papillomavirus vaccine in young women , 2003, International journal of STD & AIDS.

[10]  K. Bogenschneider,et al.  Parent-Teen Communication About Sexual Topics , 1998, Journal of family issues.

[11]  H. D. de Melker,et al.  Negative attitude of highly educated parents and health care workers towards future vaccinations in the Dutch childhood vaccination program. , 2005, Vaccine.

[12]  L. Barker,et al.  Are parental vaccine safety concerns associated with receipt of measles-mumps-rubella, diphtheria and tetanus toxoids with acellular pertussis, or hepatitis B vaccines by children? , 2004, Archives of pediatrics & adolescent medicine.

[13]  Cosette M Wheeler,et al.  Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial. , 2005, The Lancet. Oncology.

[14]  N. Kitchin,et al.  Determinants of universal adolescent hepatitis B vaccine uptake , 2004, Archives of Disease in Childhood.

[15]  A. Hinds,et al.  Acceptability of universal hepatitis B vaccination among school pupils and parents. , 2004, Communicable disease and public health.

[16]  Anne M Johnson,et al.  Ethnic variations in sexual behaviour in Great Britain and risk of sexually transmitted infections: a probability survey , 2005, The Lancet.

[17]  James P. Hughes,et al.  The Theoretical Population-Level Impact of a Prophylactic Human Papilloma Virus Vaccine , 2002, Epidemiology.

[18]  G. Zimet,et al.  Acceptability of Genital Herpes Immunization: The Role of Health Beliefs and Health Behaviors , 1997, Sexually transmitted diseases.

[19]  D. Ferris,et al.  Human papillomavirus vaccine acceptability among parents of 10- to 15-year-old adolescents. , 2004 .

[20]  A. Moscicki,et al.  The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women. , 1998, The Journal of pediatrics.

[21]  H. Kitchener,et al.  Biological and hormonal markers of chlamydia, human papillomavirus, and bacterial vaginosis among adolescents attending genitourinary medicine clinics , 2005, Sexually Transmitted Infections.

[22]  M. Ross,et al.  Ethnicity in sexually transmitted infections and sexual behaviour research , 2005, The Lancet.

[23]  M. Gagnon,et al.  Young adults and HIV vaccine: determinants of the intention of getting immunized. , 2000, Canadian journal of public health = Revue canadienne de sante publique.

[24]  Ross Upshur,et al.  Vaccines in the public eye , 2005, Nature Medicine.

[25]  L. Koutsky,et al.  Do Condoms Prevent Genital HPV Infection, External Genital Warts, or Cervical Neoplasia?: A Meta-Analysis , 2002, Sexually transmitted diseases.

[26]  L. Young,et al.  High incidence of cervical human papillomavirus infection in women during their first sexual relationship , 2002, BJOG : an international journal of obstetrics and gynaecology.

[27]  Thomas Lumley,et al.  Analysis of Complex Survey Samples , 2004 .