Evaluation of magnetic nanoparticle samples made from biocompatible ferucarbotran by time-correlation magnetic particle imaging reconstruction method

BackgroundMolecular imaging using magnetic nanoparticles (MNPs)—magnetic particle imaging (MPI)—has attracted interest for the early diagnosis of cancer and cardiovascular disease. However, because a steep local magnetic field distribution is required to obtain a defined image, sophisticated hardware is required. Therefore, it is desirable to realize excellent image quality even with low-performance hardware. In this study, the spatial resolution of MPI was evaluated using an image reconstruction method based on the correlation information of the magnetization signal in a time domain and by applying MNP samples made from biocompatible ferucarbotran that have adjusted particle diameters.MethodsThe magnetization characteristics and particle diameters of four types of MNP samples made from ferucarbotran were evaluated. A numerical analysis based on our proposed method that calculates the image intensity from correlation information between the magnetization signal generated from MNPs and the system function was attempted, and the obtained image quality was compared with that using the prototype in terms of image resolution and image artifacts.ResultsMNP samples obtained by adjusting ferucarbotran showed superior properties to conventional ferucarbotran samples, and numerical analysis showed that the same image quality could be obtained using a gradient magnetic field generator with 0.6 times the performance. However, because image blurring was included theoretically by the proposed method, an algorithm will be required to improve performance.ConclusionsMNP samples obtained by adjusting ferucarbotran showed magnetizing properties superior to conventional ferucarbotran samples, and by using such samples, comparable image quality (spatial resolution) could be obtained with a lower gradient magnetic field intensity.

[1]  Keiji Enpuku,et al.  Characterization of Resovist® Nanoparticles for Magnetic Particle Imaging , 2012 .

[2]  B Gleich,et al.  Three-dimensional real-time in vivo magnetic particle imaging , 2009, Physics in medicine and biology.

[3]  T. Dougherty.  Photodynamic therapy. , 1993, Photochemistry and photobiology.

[4]  Hiraku Okada,et al.  Technical Report of IEICE , 2000 .

[5]  S. Loening,et al.  Presentation of a new magnetic field therapy system for the treatment of human solid tumors with magnetic fluid hyperthermia , 2001 .

[6]  伴野 雄三,et al.  Soshin Chikazumi: Physics of Magnetism, John Wiley and Sons, New York, 1964, 554頁, 15×23cm. , 1966 .

[7]  Lutz Trahms,et al.  How the size distribution of magnetic nanoparticles determines their magnetic particle imaging performance , 2011 .

[8]  D. Eberbeck,et al.  Optimization of Magnetic Nanoparticles for Magnetic Particle Imaging , 2012, IEEE Transactions on Magnetics.

[9]  Kevin R Minard,et al.  Optimization of nanoparticle core size for magnetic particle imaging. , 2009, Journal of magnetism and magnetic materials.

[10]  P. Jain,et al.  Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy. , 2007, Nanomedicine.

[11]  Dirk Schüler,et al.  Magnetic properties of bacterial magnetosomes as potential diagnostic and therapeutic tools , 2005 .

[12]  Roy W. Chantrell,et al.  Measurements of particle size distribution parameters in ferrofluids , 1978 .

[13]  Bernhard Gleich,et al.  First phantom and in vivo MPI images with an extended field of view , 2011, Medical Imaging.

[14]  S. Charap,et al.  Physics of magnetism , 1964 .

[15]  Yasutoshi Ishihara,et al.  Correlation-Based Image Reconstruction Methods for Magnetic Particle Imaging , 2012, IEICE Trans. Inf. Syst..

[16]  Patrick W. Goodwill,et al.  Narrowband Magnetic Particle Imaging , 2009, IEEE Transactions on Medical Imaging.

[17]  Patrick W. Goodwill,et al.  The X-Space Formulation of the Magnetic Particle Imaging Process: 1-D Signal, Resolution, Bandwidth, SNR, SAR, and Magnetostimulation , 2010, IEEE Transactions on Medical Imaging.

[18]  Xiaohua Huang,et al.  Selective laser photo-thermal therapy of epithelial carcinoma using anti-EGFR antibody conjugated gold nanoparticles. , 2006, Cancer letters.

[19]  Kevin R Minard,et al.  Optimizing magnetite nanoparticles for mass sensitivity in magnetic particle imaging. , 2011, Medical physics.

[20]  Bernhard Gleich,et al.  Tomographic imaging using the nonlinear response of magnetic particles , 2005, Nature.

[21]  R. K. Rao Yarlagadda,et al.  Analog and Digital Signals and Systems , 2009 .