A COMPREHENSIVE REVIEW ON HYDROGEL AND NOVEL APPLICATIONS IN PHARMACEUTICS

Hydrogel is with chemicals or physically crosslinked, three-dimensional chemical compound network, extensively employed in varied medicine and pharmaceutical applications. It will swell and hold an outsized quantity of biological fluid and water whereas, maintaining its structure while not dissolution. By dominant the cross-linker density, precursor content and property, the porous structure of gel may be tuned. The mix of biocompatibility, biodegradability, porous structure, extraordinary capability of retentive water and biological fluid mimic the extracellular matrix. Therefore, it may be employed in numerous biological applications like membrane for biosensor drug delivery lining for implant material for covering, and tissue engineering [1]. Even though hydrogels are employed in numerous industries, additional researches are getting in the sphere of medical specialty applications due to its resembles to living tissue, biocompatibility, and biodegradability [2]. By chemical approaches, the polymers are certain along through valency bonds that endow environmental stability and intensive mechanical strength. Compared, physical hydrogels trust non-covalent interactions like H bonding, electricity interactions, and metal-ligand coordination [3]. The extremely porous structure of gel will simply be tuned by dominant the density of cross-links within the gel matrix and therefore, the affinity of the hydrogels for the liquid surroundings within which they're swollen. Their consistence additionally permits loading of medication into the gel matrix and resulting drug unharness at a rate keen about the diffusion constant of a tiny low molecule or a super molecule through the gel network [4].

[1]  M. Krishnan,et al.  Thermo-elastic and self-healing polyacrylamide -2D nanofiller composite hydrogels for water shutoff treatment , 2020 .

[2]  Yufeng Zheng,et al.  Rapid bacteria trapping and killing of metal-organic frameworks strengthened photo-responsive hydrogel for rapid tissue repair of bacterial infected wounds , 2020 .

[3]  S. Qin,et al.  Paclitaxel-nanoparticles-loaded double network hydrogel for local treatment of breast cancer after surgical resection. , 2020, Materials science & engineering. C, Materials for biological applications.

[4]  Baolin Guo,et al.  Conductive adhesive self-healing nanocomposite hydrogel wound dressing for photothermal therapy of infected full-thickness skin wounds , 2020 .

[5]  T. Jiao,et al.  Facile preparation of black phosphorus-based rGO-BP-Pd composite hydrogels with enhanced catalytic reduction of 4-nitrophenol performances for wastewater treatment , 2020 .

[6]  Guozheng Zhang,et al.  A transparent sericin-polyacrylamide interpenetrating network hydrogel as visualized dressing material , 2020 .

[7]  Cao Hui,et al.  Synthesis and characterization of an injectable ε-polylysine/carboxymethyl chitosan hydrogel used in medical application , 2020 .

[8]  A. Zamanian,et al.  Synthesis and characterization of timolol maleate-loaded quaternized chitosan-based thermosensitive hydrogel: A transparent topical ocular delivery system for the treatment of glaucoma. , 2020, International journal of biological macromolecules.

[9]  S. Techasakul,et al.  Characterization, release, and antioxidant activity of caffeic acid-loaded collagen and chitosan hydrogel composites , 2020 .

[10]  Tamal Banerjee,et al.  Chemically crosslinked xylan-β-Cyclodextrin hydrogel for the in vitro delivery of curcumin and 5-Fluorouracil. , 2020, International journal of biological macromolecules.

[11]  I. Manjubala,et al.  Commercial hydrogels for biomedical applications , 2020, Heliyon.

[12]  D. Ekinci,et al.  Multifunctional alginate-based hydrogel with reversible crosslinking for controlled therapeutics delivery. , 2020, International journal of biological macromolecules.

[13]  Zhi-geng Jin,et al.  Combining ECM Hydrogels of Cardiac Bioactivity with Stem Cells of High Cardiomyogenic Potential for Myocardial Repair , 2019, Stem cells international.

[14]  Abdul Nasir Kurnool,et al.  Long Acting Injectables-An Overview , 2019 .

[15]  S. Mohan,et al.  An Insight into Hydrogel Drug Delivery , 2019 .

[16]  ohammed Ali Mutar,et al.  Injectable Glucose-Responsive Hydrogels as Insulin Delivery Systems for Diabetes Treatment Based on Boronic Acid−Glucose Complexation , 2018 .

[17]  L. Yadav,et al.  Ocular Drug Delivery System & Role of Ocular Inserts In Eye Disorder Treatment : A Review , 2018 .

[18]  Tarabai Bandekar Hydrogels: Introduction, Preparation, Characterization and Applications , 2015 .

[19]  Radhika Arjunkumar,et al.  Nanocomposite Hydrogels as Local Drug Delivery in Periodontics , 2014 .

[20]  S. Muralidharan,et al.  Development and in vitro Evalution of Guar Gum based Fluconazole in situ Gel for Oral Thrush , 2012 .

[21]  Vijay D. Wagh,et al.  Formulation and Evaluation of in situ Gel Drug Delivery System of Sesbania grandiflora Flower Extract for the Treatment of Bacterial Conjunctivitis , 2012 .

[22]  Y. Ali,et al.  Industrial perspective in ocular drug delivery. , 2006, Advanced drug delivery reviews.

[23]  Yasmin Sultana,et al.  Review of ocular drug delivery. , 2006, Current drug delivery.

[24]  A. Ravve,et al.  Principles of Polymer Chemistry , 1995 .

[25]  J. LaMotte,et al.  The efficacy of cellulosic ophthalmic inserts for treatment of dry eye. , 1985, Journal of the American Optometric Association.

[26]  S. Lerman,et al.  Prolonged release hydrocortisone therapy. , 1973, Canadian journal of ophthalmology. Journal canadien d'ophtalmologie.

[27]  A. A. Swanson,et al.  Ophthalmic vehicles. II. Comparison of ointment and polyvinyl alcohol 1.4 per cent. , 1970, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.