Collaboration in pharmaceutical research: exploration of country-level determinants

In this paper we focus on proximity as one of the main determinants of international collaboration in pharmaceutical research. We use various count data specifications of the gravity model to estimate the intensity of collaboration between pairs of countries as explained by the geographical, cognitive, institutional, social, and cultural dimensions of proximity. Our results suggest that geographical distance has a significant negative relation to the collaboration intensity between countries. The amount of previous collaborations, as a proxy for social proximity, is positively related to the number of cross-country collaborations. We do not find robust significant associations between cognitive proximity or institutional proximity with the intensity of international research collaboration. Our findings for cultural proximity do not allow of unambiguous conclusions concerning their influence on the collaboration intensity between countries.

[1]  André Torre,et al.  Proximity and Localization , 2005 .

[2]  J. Howells Tacit Knowledge, Innovation and Economic Geography , 2002 .

[3]  Jarno Hoekman,et al.  Death of Distance in Science? A Gravity Approach to Research Collaboration , 2009 .

[4]  Uwe Cantner,et al.  The Network of Innovators in Jena: An Application of Social Network Analysis , 2006 .

[5]  R. Boschma Proximity and Innovation: A Critical Assessment , 2005 .

[6]  Bj⊘rn Asheim,et al.  Face-to-Face, Buzz, and Knowledge Bases: Sociospatial Implications for Learning, Innovation, and Innovation Policy , 2007 .

[7]  A. Cameron,et al.  Regression-based tests for overdispersion in the Poisson model☆ , 1990 .

[8]  R. Henderson,et al.  Public-private interaction in pharmaceutical research. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[9]  Pierre-Alexandre Balland,et al.  Proximity and the Evolution of Collaboration Networks: Evidence from Research and Development Projects within the Global Navigation Satellite System (GNSS) Industry , 2012 .

[10]  P. S. Nagpaul Exploring a pseudo-regression model of transnational cooperation in science , 2003, Scientometrics.

[11]  Manuel Acosta,et al.  Factors affecting inter-regional academic scientific collaboration within Europe: the role of economic distance , 2011, Scientometrics.

[12]  Martijn Burger,et al.  On the Specification of the Gravity Model of Trade: Zeros, Excess Zeros and Zero-Inflated Estimation , 2009 .

[13]  J. Hoekman,et al.  The geography of collaborative knowledge production in Europe , 2009 .

[14]  R. Tijssen Measuring the Corporate Web of Science: Research and Partnership Networks within the European Pharmaceutical Industry , 2009 .

[15]  Farid Toubal,et al.  Cultural Proximity and Trade , 2006 .

[16]  Basil Achilladelis,et al.  The dynamics of technological innovation : the case of the pharmaceutical industry , 2001 .

[17]  B. Nooteboom Learning and Innovation in Organizations and Economies , 2000 .

[18]  Sujin Choi Core-periphery, new clusters, or rising stars?: international scientific collaboration among ‘advanced’ countries in the era of globalization , 2011, Scientometrics.

[19]  Francis Narin,et al.  Scientific co-operation in Europe and the citation of multinationally authored papers , 1991, Scientometrics.

[20]  Stefano Breschi,et al.  Tracing the links between science and technology: An exploratory analysis of scientists' and inventors' networks , 2010 .

[21]  S. Bartholomew National Systems of Biotechnology Innovation: Complex Interdependence in the Global System , 1997 .

[22]  Maureen McKelvey,et al.  Pharmaceuticals Analyzed through the Lens of a Sectoral Innovation System , 2004 .

[23]  M. Barber,et al.  Distinct spatial characteristics of industrial and public research collaborations: evidence from the fifth EU Framework Programme , 2010, 1004.3685.

[24]  John Metcalfe,et al.  Mapping evolutionary trajectories: Applications to the growth and transformation of medical knowledge , 2007 .

[25]  W. Isard Location Theory and Trade Theory: Short-Run Analysis , 1954 .

[26]  F. Malerba Sectoral Systems of Innovation: Concepts, Issues and Analyses of Six Major Sectors in Europe , 2009 .

[27]  Silvana Tenreyro,et al.  The Log of Gravity , 2004 .

[28]  Nelius Boshoff,et al.  Neo-colonialism and research collaboration in Central Africa , 2009, Scientometrics.

[29]  L. Freeman Centrality in social networks conceptual clarification , 1978 .

[30]  Vladimir Batagelj,et al.  Exploratory Social Network Analysis with Pajek , 2005 .

[31]  W. Shan,et al.  Country—specific advantage and international cooperation , 1991 .

[32]  Jeffrey L. Furman,et al.  The Determinants of National Innovative Capacity , 2000 .

[33]  C. Edquist Systems of Innovation: Technologies, Institutions and Organizations , 1997 .

[34]  Koen Frenken,et al.  The geographical and institutional proximity of research collaboration , 2007 .

[35]  Yoshiko Okubo,et al.  Structure of international collaboration in science-part II: Comparisons of profiles in countries using a link indicator , 1994, Scientometrics.

[36]  Stanley Wasserman,et al.  Social Network Analysis: Methods and Applications , 1994, Structural analysis in the social sciences.

[37]  Bj⊘rn Asheim,et al.  Nodes, networks and proximities: on the knowledge dynamics of the Medicon Valley biotech cluster , 2004 .

[38]  B. Dalum National Systems of Innovation: Towards a Theory of Innovation and Interactive Learning , 1992 .

[39]  O. Gassmann,et al.  New concepts and trends in international R&D organization , 1999 .

[40]  Massimo Riccaboni,et al.  Technological change and network dynamics: Lessons from the pharmaceutical industry , 2001 .

[41]  Mark S. Granovetter Economic Action and Social Structure: The Problem of Embeddedness , 1985, American Journal of Sociology.

[42]  A. Shaw,et al.  On the Analytical Dimension of Proximity Dynamics , 2000 .

[43]  Wolfgang Glänzel,et al.  Cross-national preference in co-authorship, references and citations , 2006, Scientometrics.

[44]  Thomas Scherngell,et al.  Collaborative Knowledge Production in China: Regional Evidence from a Gravity Model Approach , 2011 .

[45]  Q. Vuong Likelihood Ratio Tests for Model Selection and Non-Nested Hypotheses , 1989 .

[46]  R. Tijssen,et al.  Acquisition of European research funds and its effect on international scientific collaboration. , 2013 .

[47]  M. Barber,et al.  Spatial interaction modelling of cross-region R&D collaborations: empirical evidence from the 5th EU framework programme , 2009, 1004.3425.

[48]  Apresentação Paulo Bastos Tigre Bengt-Åke Lundvall - Innovation as an interactive process: from user-producer interaction to the national system of innovation , 2009 .

[49]  Duncan J. Watts,et al.  Collective dynamics of ‘small-world’ networks , 1998, Nature.

[50]  John Cantwell,et al.  The Role of Multinational Corporations and National States in the Globalization of Innovatory Capacity: The European Perspective , 2000 .

[51]  M. Aitkin,et al.  A method of fitting the gravity model based on the Poisson distribution. , 1982, Journal of regional science.

[52]  Leonard M. Freeman,et al.  A set of measures of centrality based upon betweenness , 1977 .

[53]  G. Laudel What do we measure by co-authorships? , 2002 .

[54]  E. Helpman,et al.  ESTIMATING TRADE FLOWS : TRADING PARTNERS AND TRADING VOLUMES Elhanan Helpman , 2007 .

[55]  Roberta Capello,et al.  Technological interdependence and regional growth in Europe: Proximity and synergy in knowledge spillovers , 2012 .

[56]  Daniel A. Levinthal,et al.  ABSORPTIVE CAPACITY: A NEW PERSPECTIVE ON LEARNING AND INNOVATION , 1990 .

[57]  J. Hagedoorn Inter-firm R&D partnerships: an overview of major trends and patterns since 1960 , 2002 .

[58]  Benjamin F. Jones,et al.  Supporting Online Material Materials and Methods Figs. S1 to S3 References the Increasing Dominance of Teams in Production of Knowledge , 2022 .

[59]  A. Jaffe Technological Opportunity and Spillovers of R&D: Evidence from Firms&Apos; Patents, Profits and Market Value , 1986 .

[60]  Paula E. Stephan,et al.  Scientific Teams and Institution Collaborations: Evidence from U.S. Universities, 1981-1999 , 2004 .

[61]  Robert J. W. Tijssen,et al.  Is the commercialisation of scientific research affecting the production of public knowledge?: Global trends in the output of corporate research articles , 2004 .

[62]  A. Szirmai,et al.  Institutional Profiles Database III Presentation of the "Institutional Profiles Database 2009" (IPD 2009) , 2009 .

[63]  Ron Boschma,et al.  Knowledge networks in the Dutch aviation industry: The proximity paradox , 2012 .

[64]  Caroline S. Wagner,et al.  Mapping the network of global science: comparing international co-authorships from 1990 to 2000 , 2005 .

[65]  Thed N. van Leeuwen,et al.  Research cooperation within the bio-pharmaceutical industry: Network analyses of co-publications within and between firms , 2007, Scientometrics.

[66]  Michel Zitt,et al.  Shadows of the Past in International Cooperation: Collaboration Profiles of the Top Five Producers of Science , 2000, Scientometrics.

[67]  Jacques Melitz,et al.  Language and Foreign Trade , 2002 .

[68]  R. Boschma,et al.  Evolutionary economics and economic geography , 1999 .

[69]  R. Tijssen,et al.  Research collaboration at a distance: Changing spatial patterns of scientific collaboration within Europe , 2010 .

[70]  D. Price Little Science, Big Science , 1965 .

[71]  A. Agrawal,et al.  Gone but not Forgotten: Knowledge Flows, Labor Mobility, and Enduring Social Relationships , 2006 .

[72]  T. Mayer,et al.  Notes on CEPII’s distances measures , 2006 .

[73]  O. Persson,et al.  Understanding Patterns of International Scientific Collaboration , 1992 .

[74]  Edward M. Reingold,et al.  Graph drawing by force‐directed placement , 1991, Softw. Pract. Exp..

[75]  C. Edquist,et al.  Institutions and Organizations in Systems of Innovation , 2013 .

[76]  Patrice Laget,et al.  Intra-EU vs. extra-EU scientific co-publication patterns in EU , 2008, Scientometrics.

[77]  B. Spilker,et al.  Science and Innovation: The US Pharmaceutical Industry During the 1980s , 1996 .

[78]  Bart Verspagen,et al.  Mapping Technological Trajectories as Patent citation Networks: a Study on the History of Fuel Cell Research , 2007, Adv. Complex Syst..

[79]  W. Greene,et al.  Accounting for Excess Zeros and Sample Selection in Poisson and Negative Binomial Regression Models , 1994 .

[80]  A. Gambardella Competitive advantages from in-house scientific research: The US pharmaceutical industry in the 1980s * , 1992 .

[81]  Jonas Lundberg,et al.  Collaboration uncovered: Exploring the adequacy of measuring university-industry collaboration through co-authorship and funding , 2006, Scientometrics.

[82]  M. Feldman,et al.  R&D spillovers and the ge-ography of innovation and production , 1996 .

[83]  魏屹东,et al.  Scientometrics , 2018, Encyclopedia of Big Data.

[84]  Giovanni Peri,et al.  Determinants of Knowledge Flows and Their Effect on Innovation , 2005, Review of Economics and Statistics.

[85]  Christian Zeller North Atlantic Innovative Relations of Swiss Pharmaceuticals and the Proximities with Regional Biotech Arenas , 2004 .

[86]  Yannick Lung,et al.  Innovation and Proximity , 1999 .

[87]  Silvana Tenreyro,et al.  The Log of Gravity , 2004, The Review of Economics and Statistics.

[88]  Uwe Cantner,et al.  Technological proximity and the choice of cooperation partner , 2007 .

[89]  J. Tinbergen Shaping the World Economy: Suggestions for an International Economic Policy , 1964 .

[90]  Meric S. Gertler,et al.  “Being There”: Proximity, Organization, and Culture in the Development and Adoption of Advanced Manufacturing Technologies , 1995 .

[91]  Luc Soete,et al.  The economics of technical change and international trade , 1994 .

[92]  J. S. Katz,et al.  What is research collaboration , 1997 .

[93]  C. Autant‐Bernard,et al.  Social distance versus spatial distance in R & D cooperation: Empirical evidence from European collaboration choices in micro and nanotechnologies , 2007 .

[94]  Alfonso Gambardella Science and innovation , 1995 .