Theoretical model of optical coherence tomography for system optimization and characterization.

We present a detailed analytical model to describe optical coherence tomography (OCT) systems, which considers the propagation of the optical field within a scattering medium in the framework of the extended Huygens-Fresnel principle. The model includes use of the discrete-particle model and the fractal approach in treating biological tissue as being packed with scattering particles with a power-law distribution. In contrast to previous models, an imaginary lens proximal to the tissue surface is introduced that approximates the real focusing lens in the sample arm of the OCT system. This treatment avoids the consideration of backscattering light as traveling in the free space between the focusing lens and the tissue surface before mixing with the reference beam. Experiments on tissue phantoms were carried out to verify the validity of this model.

[1]  Bernard Gelebart,et al.  Phase function simulation in tissue phantoms: a fractal approach , 1996 .

[2]  J. Izatt,et al.  High-resolution cross-sectional imaging of the gastrointestinal tract using optical coherence tomography: preliminary results. , 1998, Gastrointestinal endoscopy.

[3]  J. Schmitt,et al.  Optical scattering properties of soft tissue: a discrete particle model. , 1998, Applied optics.

[4]  J. Fujimoto,et al.  New Technology for High‐Speed and High‐Resolution Optical Coherence Tomography a , 1998, Annals of the New York Academy of Sciences.

[5]  R Birngruber,et al.  Contrast limits of coherence-gated imaging in scattering media. , 1997, Applied optics.

[6]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[7]  H. Yura,et al.  Analysis of optical coherence tomography systems based on the extended Huygens-Fresnel principle. , 2000, Journal of the Optical Society of America. A, Optics, image science, and vision.

[8]  U Seitz,et al.  First in vivo optical coherence tomography in the human bile duct. , 2001, Endoscopy.

[9]  James G. Fujimoto,et al.  Feasibility of optical coherence tomography for high-resolution imaging of human gastrointestinal tract malignancies , 2000, Journal of Gastroenterology.

[10]  R Birngruber,et al.  Optical coherence tomography of the human skin. , 1997, Journal of the American Academy of Dermatology.

[11]  Ruikang K. Wang.  Modelling optical properties of soft tissue by fractal distribution of scatterers , 2000 .

[12]  R. Lutomirski,et al.  Propagation of a finite optical beam in an inhomogeneous medium. , 1971, Applied optics.

[13]  Joseph M. Schmitt,et al.  MODEL OF OPTICAL COHERENCE TOMOGRAPHY OF HETEROGENEOUS TISSUE , 1997 .

[14]  Xiangqun Xu,et al.  Dynamic optical coherence tomography in studies of optical clearing, sedimentation, and aggregation of immersed blood. , 2002, Applied optics.

[15]  J M Schmitt,et al.  Subsurface imaging of living skin with optical coherence microscopy. , 1995, Dermatology.

[16]  J. Duker,et al.  Imaging of macular diseases with optical coherence tomography. , 1995, Ophthalmology.

[17]  H. J. van Staveren,et al.  Light scattering in Intralipid-10% in the wavelength range of 400-1100 nm. , 1991, Applied optics.

[18]  R Birngruber,et al.  Low-coherence optical tomography in turbid tissue: theoretical analysis. , 1995, Applied optics.

[19]  H. T. Yura,et al.  Signal-to-noise Ratio of Heterodyne Lidar Systems in the Presence of Atmospheric Turbulence , 1979 .

[20]  J M Schmitt,et al.  Cross-polarized backscatter in optical coherence tomography of biological tissue. , 1998, Optics letters.

[21]  Ruikang K. Wang,et al.  Propylene glycol as a contrasting agent for optical coherence tomography to image gastrointestinal tissues , 2002, Lasers in surgery and medicine.

[22]  Ruikang K. Wang,et al.  High-resolution optical tomographic imaging of soft biological tissues , 2001, Saratov Fall Meeting.

[23]  Valery V. Tuchin,et al.  Concurrent enhancement of imaging depth and contrast for optical coherence tomography by hyperosmotic agents , 2001 .

[24]  L L Otis,et al.  Imaging of hard- and soft-tissue structure in the oral cavity by optical coherence tomography. , 1998, Applied optics.

[25]  Steen G. Hanson,et al.  Effects of receiver optics contamination on the performance of laser velocimeter systems , 1996 .

[26]  Joseph M. Schmitt,et al.  Optical coherence tomography (OCT): a review , 1999 .

[27]  Dirk Boecker,et al.  Analytical modeling of spatial resolution curves in turbid media acquired with optical coherence tomography (OCT) , 1996, Electronic Imaging.

[28]  A. Fercher,et al.  In vivo human retinal imaging by Fourier domain optical coherence tomography. , 2002, Journal of biomedical optics.

[29]  N Tsurumachi,et al.  Wide-field optical coherence tomography: imaging of biological tissues. , 2002, Applied optics.