Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium.

[1]  A. Grapin-Botton,et al.  Neurogenin3 initiates stepwise delamination of differentiating endocrine cells during pancreas development , 2011, Developmental dynamics : an official publication of the American Association of Anatomists.

[2]  C. Wright,et al.  Neurog3 gene dosage regulates allocation of endocrine and exocrine cell fates in the developing mouse pancreas. , 2010, Developmental biology.

[3]  C. Orvain,et al.  Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development , 2010, Development.

[4]  L. Bouwens,et al.  Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth. , 2009, Developmental cell.

[5]  M. Permutt,et al.  Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window. , 2009, Genes & development.

[6]  K. Kaestner,et al.  Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas , 2009, Mechanisms of Development.

[7]  Thomas J. Carroll,et al.  Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis , 2009, Nature Genetics.

[8]  Marcus Fruttiger,et al.  The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis , 2009, Cell.

[9]  M. Fortini,et al.  Notch signaling: the core pathway and its posttranslational regulation. , 2009, Developmental cell.

[10]  B. Stanger,et al.  Notch signaling controls liver development by regulating biliary differentiation , 2009, Development.

[11]  Raphael Kopan,et al.  The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism , 2009, Cell.

[12]  S. Schreiber,et al.  Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. , 2009, Cell stem cell.

[13]  S. Schreiber,et al.  A small molecule that directs differentiation of human ESCs into the pancreatic lineage. , 2009, Nature chemical biology.

[14]  H. Edlund,et al.  MFng Is Dispensable for Mouse Pancreas Development and Function , 2009, Molecular and Cellular Biology.

[15]  K. Kaestner,et al.  Dynamic regulation of Pdx1 enhancers by Foxa1 and Foxa2 is essential for pancreas development. , 2008, Genes & development.

[16]  M. Sander,et al.  A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. , 2008, Developmental biology.

[17]  P. Mazur,et al.  Conditional ablation of Notch signaling in pancreatic development , 2008, Development.

[18]  C. Wright,et al.  Pdx-1 and Ptf1a concurrently determine fate specification of pancreatic multipotent progenitor cells. , 2008, Developmental biology.

[19]  E. Kroon,et al.  Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo , 2008, Nature Biotechnology.

[20]  Jacob Hecksher-Sørensen,et al.  An Improved Method for Three-dimensional Reconstruction of Protein Expression Patterns in Intact Mouse and Chicken Embryos and Organs , 2007, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[21]  D. Melton,et al.  A multipotent progenitor domain guides pancreatic organogenesis. , 2007, Developmental cell.

[22]  M. Hebrok,et al.  Dynamics of embryonic pancreas development using real-time imaging. , 2007, Developmental biology.

[23]  R. Kist,et al.  SOX9 is required for maintenance of the pancreatic progenitor cell pool , 2007, Proceedings of the National Academy of Sciences.

[24]  J. Habener,et al.  Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas. , 2007, Gene expression patterns : GEP.

[25]  D. Melton,et al.  Notch signaling reveals developmental plasticity of Pax4 + pancreatic endocrine progenitors and shunts them to a duct fate , 2007, Mechanisms of Development.

[26]  C. Orvain,et al.  Transcription factors in pancreatic development. Animal models. , 2007, Endocrine development.

[27]  J. Ahnfelt-Rønne,et al.  Preservation of proliferating pancreatic progenitor cells by Delta-Notch signaling in the embryonic chicken pancreas , 2007, BMC Developmental Biology.

[28]  Vivek Kapur,et al.  Differentiation of Embryonic Stem Cells Conditionally Expressing Neurogenin 3 , 2006, Stem cells.

[29]  E. Kroon,et al.  Production of pancreatic hormone–expressing endocrine cells from human embryonic stem cells , 2006, Nature Biotechnology.

[30]  B. Stanger,et al.  The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3. , 2006, Developmental biology.

[31]  S. Bray.  Notch signalling: a simple pathway becomes complex , 2006, Nature Reviews Molecular Cell Biology.

[32]  A. Bounacer,et al.  The Mesenchyme Controls the Timing of Pancreatic β-Cell Differentiation , 2006 .

[33]  A. Bounacer,et al.  The mesenchyme controls the timing of pancreatic beta-cell differentiation. , 2006, Diabetes.

[34]  E. Kroon,et al.  Efficient differentiation of human embryonic stem cells to definitive endoderm , 2005, Nature Biotechnology.

[35]  B. Sosa-Pineda,et al.  Prox1 activity controls pancreas morphogenesis and participates in the production of "secondary transition" pancreatic endocrine cells. , 2005, Developmental biology.

[36]  Michael R. Barnes,et al.  Proendocrine genes coordinate the pancreatic islet differentiation program in vitro. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[37]  F. Real,et al.  Notch inhibits Ptf1 function and acinar cell differentiation in developing mouse and zebrafish pancreas , 2004, Development.

[38]  Susan E. Schonhoff,et al.  Neurogenin 3-expressing progenitor cells in the gastrointestinal tract differentiate into both endocrine and non-endocrine cell types. , 2004, Developmental biology.

[39]  D. Melton,et al.  Notch signaling controls multiple steps of pancreatic differentiation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[40]  J. Hald,et al.  Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development. , 2003, Developmental biology.

[41]  C. Wright,et al.  The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors , 2002, Nature Genetics.

[42]  D. Melton,et al.  Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. , 2002, Development.

[43]  M S German,et al.  Regulation of the pancreatic pro-endocrine gene neurogenin3. , 2001, Diabetes.

[44]  Shankar Srinivas,et al.  Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus , 2001, BMC Developmental Biology.

[45]  H. Watada,et al.  Regulation of the Pancreatic Pro-Endocrine Gene , 2001 .

[46]  F. Guillemot,et al.  neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[47]  O. Madsen,et al.  Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation. , 2000, Diabetes.

[48]  Julian Lewis,et al.  Getting to the guts of enteroendocrine differentiation , 2000, Nature genetics.

[49]  Ryoichiro Kageyama,et al.  Control of endodermal endocrine development by Hes-1 , 2000, Nature Genetics.

[50]  David J. Anderson,et al.  Notch signalling controls pancreatic cell differentiation , 1999, Nature.

[51]  E. Casanova,et al.  Inducible site-specific recombination in the brain. , 1999, Journal of molecular biology.

[52]  J. Lewis,et al.  Notch signalling and the control of cell fate choices in vertebrates. , 1998, Seminars in cell & developmental biology.

[53]  P. Gruss,et al.  The Pax4 gene is essential for differentiation of insulin-producing β cells in the mammalian pancreas , 1997, Nature.

[54]  P Gruss,et al.  Pax6 is required for differentiation of glucagon-producing alpha-cells in mouse pancreas. , 1997, Nature.