NK cell education via nonclassical MHC and non-MHC ligands

[1]  C. Lenoir,et al.  A hematopoietic cell–driven mechanism involving SLAMF6 receptor, SAP adaptors and SHP-1 phosphatase regulates NK cell education , 2016, Nature Immunology.

[2]  H. Sekhon,et al.  Influenza Virus Targets Class I MHC-Educated NK Cells for Immunoevasion , 2016, PLoS pathogens.

[3]  E. Wisse,et al.  Liver natural killer cells: subsets and roles in liver immunity , 2015, Cellular and Molecular Immunology.

[4]  Björn Önfelt,et al.  Microchip-Based Single-Cell Imaging Reveals That CD56dimCD57−KIR−NKG2A+ NK Cells Have More Dynamic Migration Associated with Increased Target Cell Conjugation and Probability of Killing Compared to CD56dimCD57−KIR−NKG2A− NK Cells , 2015, The Journal of Immunology.

[5]  A. Porgador,et al.  NKp46 Clusters at the Immune Synapse and Regulates NK Cell Polarization , 2015, Front. Immunol..

[6]  N. Kadri,et al.  Selection, tuning, and adaptation in mouse NK cell education , 2015, Immunological reviews.

[7]  K. Malmberg,et al.  Newtonian cell interactions shape natural killer cell education , 2015, Immunological reviews.

[8]  J. Routy,et al.  A Higher Frequency of NKG2A+ than of NKG2A− NK Cells Responds to Autologous HIV-Infected CD4 Cells irrespective of Whether or Not They Coexpress KIR3DL1 , 2015, Journal of Virology.

[9]  Alexandre F. Carisey,et al.  Lenalidomide augments actin remodeling and lowers NK-cell activation thresholds. , 2015, Blood.

[10]  G. Abrahamsen,et al.  Coordinated Expression of DNAM-1 and LFA-1 in Educated NK Cells , 2015, The Journal of Immunology.

[11]  F. Souza-Fonseca-Guimaraes,et al.  DNAM-1 expression marks an alternative program of NK cell maturation. , 2015, Cell reports.

[12]  A. Makrigiannis,et al.  The mouse NKR-P1B:Clr-b recognition system is a negative regulator of innate immune responses. , 2015, Blood.

[13]  A. Makrigiannis,et al.  Genetic Investigation of MHC-Independent Missing-Self Recognition by Mouse NK Cells Using an In Vivo Bone Marrow Transplantation Model , 2015, The Journal of Immunology.

[14]  B. Payrastre,et al.  SHP-1-mediated inhibitory signals promote responsiveness and anti-tumour functions of natural killer cells , 2014, Nature Communications.

[15]  Z. Tian,et al.  NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma , 2014, Cellular and Molecular Immunology.

[16]  R. Sun,et al.  TIGIT safeguards liver regeneration through regulating natural killer cell‐hepatocyte crosstalk , 2014, Hepatology.

[17]  Werner Held,et al.  Adaptations of Natural Killer Cells to Self-MHC Class I , 2014, Front. Immunol..

[18]  Yong Ho Kim,et al.  NKG2D ligation relieves 2B4‐mediated NK‐cell self‐tolerance in mice , 2014, European journal of immunology.

[19]  R. Sun,et al.  T‐cell Ig and ITIM domain regulates natural killer cell activation in murine acute viral hepatitis , 2014, Hepatology.

[20]  K. Kärre,et al.  A Genetic Defect in Mice That Impairs Missing Self Recognition Despite Evidence for Normal Maturation and MHC Class I–Dependent Education of NK Cells , 2014, The Journal of Immunology.

[21]  R. Sun,et al.  CD226 Protein Is Involved in Immune Synapse Formation and Triggers Natural Killer (NK) Cell Activation via Its First Extracellular Domain* , 2014, The Journal of Biological Chemistry.

[22]  M. Huse,et al.  Inhibitory Receptor Signaling Destabilizes Immunological Synapse Formation in Primary NK Cells , 2013, Front. Immunol..

[23]  A. H. Jonsson,et al.  Natural killer cell licensing in mice with inducible expression of MHC class I , 2013, Proceedings of the National Academy of Sciences.

[24]  Eric O Long,et al.  Cutting Edge: NK Cell Licensing Modulates Adhesion to Target Cells , 2013, The Journal of Immunology.

[25]  É. Vivier,et al.  Education of Murine NK Cells Requires Both cis and trans Recognition of MHC Class I Molecules , 2013, The Journal of Immunology.

[26]  D. Nixon,et al.  Differentiation and functional regulation of human fetal NK cells. , 2013, The Journal of clinical investigation.

[27]  N. Stanietsky,et al.  Mouse TIGIT inhibits NK‐cell cytotoxicity upon interaction with PVR , 2013, European journal of immunology.

[28]  J. Trowsdale,et al.  Influence of KIR gene copy number on natural killer cell education. , 2013, Blood.

[29]  S. Tripathy,et al.  Viral infection transiently reverses activation receptor‐mediated NK cell hyporesponsiveness in an MHC class I‐independent mechanism , 2013, European journal of immunology.

[30]  R. Sun,et al.  Blocking the natural killer cell inhibitory receptor NKG2A increases activity of human natural killer cells and clears hepatitis B virus infection in mice. , 2013, Gastroenterology.

[31]  C. Watzl,et al.  NK cell cytotoxicity mediated by 2B4 and NTB-A is dependent on SAP acting downstream of receptor phosphorylation , 2013, Front. Immun..

[32]  W. Held.  Nonclassical NK cell education , 2012, Nature Immunology.

[33]  J. Rossjohn,et al.  Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells , 2012, Nature Immunology.

[34]  Baptiste N. Jaeger,et al.  When NK cells overcome their lack of education. , 2012, The Journal of clinical investigation.

[35]  B. Wilhelm,et al.  Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice. , 2012, Blood.

[36]  W. Swat,et al.  The adaptor SAP controls NK cell activation by regulating the enzymes Vav-1 and SHIP-1 and by enhancing conjugates with target cells. , 2012, Immunity.

[37]  W. Yokoyama,et al.  Unifying concepts of MHC-dependent natural killer cell education. , 2011, Trends in immunology.

[38]  B. Vandekerckhove,et al.  Inhibitory receptors specific for MHC class I educate murine NK cells but not CD8αα intestinal intraepithelial T lymphocytes. , 2011, Blood.

[39]  Baptiste N. Jaeger,et al.  Confinement of Activating Receptors at the Plasma Membrane Controls Natural Killer Cell Tolerance , 2011, Science Signaling.

[40]  N. Matsumoto,et al.  Ly49-Dependent NK Cell Licensing and Effector Inhibition Involve the Same Interaction Site on MHC Ligands , 2011, The Journal of Immunology.

[41]  P. Brodin,et al.  Current perspectives of natural killer cell education by MHC class I molecules , 2010, Nature Reviews Immunology.

[42]  W. Yokoyama,et al.  MHC class I–deficient natural killer cells acquire a licensed phenotype after transfer into an MHC class I–sufficient environment , 2010, The Journal of experimental medicine.

[43]  D. Raulet,et al.  Mature natural killer cells reset their responsiveness when exposed to an altered MHC environment , 2010, The Journal of experimental medicine.

[44]  K. Siminovitch,et al.  Elucidation of the integrin LFA-1-mediated signaling pathway of actin polarization in natural killer cells. , 2010, Blood.

[45]  R. Welsh,et al.  Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis. , 2010, The Journal of clinical investigation.

[46]  A. Veillette,et al.  Do NK cells always need a license to kill? , 2010, Nature Immunology.

[47]  L. Lanier,et al.  “Unlicensed” Natural Killer cells dominate the response to cytomegalovirus infection , 2010, Nature Immunology.

[48]  H. Ljunggren,et al.  Education of human natural killer cells by activating killer cell immunoglobulin-like receptors. , 2010, Blood.

[49]  E. Malchiodi,et al.  Distinct conformations of Ly49 natural killer cell receptors mediate MHC class I recognition in trans and cis. , 2009, Immunity.

[50]  A. Thiel,et al.  Education of hyporesponsive NK cells by cytokines , 2009, European journal of immunology.

[51]  É. Vivier,et al.  Genetic and antibody-mediated reprogramming of natural killer cell missing-self recognition in vivo , 2009, Proceedings of the National Academy of Sciences.

[52]  C. Roth,et al.  Maturation of mouse NK cells is a 4-stage developmental program. , 2009, Blood.

[53]  É. Vivier,et al.  NK Cell Responsiveness Is Tuned Commensurate with the Number of Inhibitory Receptors for Self-MHC Class I: The Rheostat Model 1 , 2009, The Journal of Immunology.

[54]  P. Brodin,et al.  NK cell education: not an on-off switch but a tunable rheostat. , 2009, Trends in immunology.

[55]  G. Leclercq,et al.  A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education. , 2009, Immunity.

[56]  Sofia Johansson,et al.  The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells. , 2009, Blood.

[57]  Peter Parham,et al.  MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response. , 2008, Blood.

[58]  Liping Yang,et al.  Continuous engagement of a self-specific activation receptor induces NK cell tolerance , 2008, The Journal of experimental medicine.

[59]  Joseph C. Sun,et al.  Tolerance of NK cells encountering their viral ligand during development , 2008, The Journal of experimental medicine.

[60]  É. Vivier,et al.  Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways. , 2008, Blood.

[61]  R. Kendig,et al.  Inappropriate Recruitment and Activity by the Src Homology Region 2 Domain-Containing Phosphatase 1 (SHP1) Is Responsible for Receptor Dominance in the SHIP-Deficient NK Cell1 , 2007, The Journal of Immunology.

[62]  Peter Chen,et al.  Cytomegalovirus evasion of innate immunity by subversion of the NKR-P1B:Clr-b missing-self axis. , 2007, Immunity.

[63]  K. Wucherpfennig,et al.  Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. , 2007, Immunity.

[64]  W. Held,et al.  Stable masking by H-2Dd cis ligand limits Ly49A relocalization to the site of NK cell/target cell contact , 2007, Proceedings of the National Academy of Sciences.

[65]  G. Leclercq,et al.  Interactions of Ly49 Family Receptors with MHC Class I Ligands in trans and cis1 , 2007, The Journal of Immunology.

[66]  W. Yokoyama,et al.  Licensing of natural killer cells by self‐major histocompatibility complex class I , 2006, Immunological reviews.

[67]  D. Middleton,et al.  Human NK cell education by inhibitory receptors for MHC class I. , 2006, Immunity.

[68]  R. Vance,et al.  Self-tolerance of natural killer cells , 2006, Nature Reviews Immunology.

[69]  Megan E. McNerney,et al.  Requirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. , 2006, Blood.

[70]  M. Smyth,et al.  CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity1 , 2006, The Journal of Immunology.

[71]  H. Ljunggren,et al.  2B4/CD48-Mediated Regulation of Lymphocyte Activation and Function 1 , 2005, The Journal of Immunology.

[72]  A. Hayday,et al.  Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance , 2005, Nature Immunology.

[73]  L. Lybarger,et al.  Licensing of natural killer cells by host major histocompatibility complex class I molecules , 2005, Nature.

[74]  R. Vance,et al.  A subset of natural killer cells achieves self-tolerance without expressing inhibitory receptors specific for self-MHC molecules. , 2005, Blood.

[75]  F. Lemonnier,et al.  Natural killer cell education in mice with single or multiple major histocompatibility complex class I molecules , 2005, The Journal of experimental medicine.

[76]  D. F. Barber,et al.  LFA-1 Contributes an Early Signal for NK Cell Cytotoxicity , 2004, The Journal of Immunology.

[77]  Megan E. McNerney,et al.  2B4 Acts As a Non–Major Histocompatibility Complex Binding Inhibitory Receptor on Mouse Natural Killer Cells , 2004, The Journal of experimental medicine.

[78]  M. Kronenberg,et al.  CD1d1 Displayed on Cell Size Beads Identifies and Enriches an NK Cell Population Negatively Regulated by CD1d11 , 2004, The Journal of Immunology.

[79]  S. Gasser,et al.  Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[80]  C. Desponts,et al.  Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation , 2002, Science.

[81]  F. Beermann,et al.  Impaired Natural Killing of MHC Class I-Deficient Targets by NK Cells Expressing a Catalytically Inactive Form of SHP-11 , 2000, The Journal of Immunology.

[82]  L. Attisano,et al.  Mouse NKR-P1B, a novel NK1.1 antigen with inhibitory function. , 1999, Journal of immunology.

[83]  M. Kronenberg,et al.  The Murine Nonclassical Class I Major Histocompatibility Complex–like CD1.1 Molecule Protects Target Cells from Lymphokine-activated Killer Cell Cytolysis , 1999, The Journal of experimental medicine.

[84]  J. Bell,et al.  HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C , 1998, Nature.

[85]  L. Lanier,et al.  Natural killer cell licensing during viral infection. , 2011, Advances in experimental medicine and biology.

[86]  H. Clark,et al.  The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells , 2009, Nature Immunology.