Interaction with WDR5 promotes target gene recognition and tumorigenesis by MYC.

[1]  Swneke D. Bailey,et al.  BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors. , 2015, Journal of proteomics.

[2]  G. Evan,et al.  Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis , 2014, Nature Communications.

[3]  L. Zender,et al.  Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles , 2014, Nature.

[4]  Marco J. Morelli,et al.  Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis , 2014, Nature.

[5]  S. Cusack,et al.  Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex , 2014, Genes & development.

[6]  Ivan G. Costa,et al.  The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification , 2014, Nucleic acids research.

[7]  R. Eisenman,et al.  Stress-induced cleavage of Myc promotes cancer cell survival , 2014, Genes & development.

[8]  W. Tansey Mammalian MYC Proteins and Cancer , 2014 .

[9]  G. Evan,et al.  Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. , 2013, Genes & development.

[10]  Charles Y. Lin,et al.  Transcriptional Amplification in Tumor Cells with Elevated c-Myc , 2012, Cell.

[11]  V. Kuznetsov,et al.  Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance , 2012, Nature Structural &Molecular Biology.

[12]  R. Young,et al.  BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc , 2011, Cell.

[13]  Susan L Young,et al.  Premetazoan ancestry of the Myc-Max network. , 2011, Molecular biology and evolution.

[14]  Jonathan M. Monk,et al.  Wdr5 Mediates Self-Renewal and Reprogramming via the Embryonic Stem Cell Core Transcriptional Network , 2011, Cell.

[15]  S. Lanouette,et al.  Structural and biochemical insights into MLL1 core complex assembly. , 2011, Structure.

[16]  Jon R. Wilson,et al.  Characterization of a Novel WDR5-binding Site That Recruits RbBP5 through a Conserved Motif to Enhance Methylation of Histone H3 Lysine 4 by Mixed Lineage Leukemia Protein-1* , 2010, The Journal of Biological Chemistry.

[17]  Shinya Yamanaka,et al.  Promotion of direct reprogramming by transformation-deficient Myc , 2010, Proceedings of the National Academy of Sciences.

[18]  C. Glass,et al.  Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. , 2010, Molecular cell.

[19]  L. Penn,et al.  Reflecting on 25 years with MYC , 2008, Nature Reviews Cancer.

[20]  M. Cosgrove,et al.  Structure of WDR5 Bound to Mixed Lineage Leukemia Protein-1 Peptide* , 2008, Journal of Biological Chemistry.

[21]  N. D. Clarke,et al.  Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells , 2008, Cell.

[22]  W. Tansey,et al.  Myc-mediated transcriptional repression by recruitment of histone deacetylase. , 2008, Cancer research.

[23]  J. Workman,et al.  ATAC is a double histone acetyltransferase complex that stimulates nucleosome sliding , 2008, Nature Structural &Molecular Biology.

[24]  Randy J. Read,et al.  Phaser crystallographic software , 2007, Journal of applied crystallography.

[25]  J. Utikal,et al.  Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. , 2007, Cell stem cell.

[26]  Zhiping Weng,et al.  Global mapping of c-Myc binding sites and target gene networks in human B cells , 2006, Proceedings of the National Academy of Sciences.

[27]  Alexey Bochkarev,et al.  Structural basis for molecular recognition and presentation of histone H3 By WDR5 , 2006, The EMBO journal.

[28]  Jianmin Zhang,et al.  Transforming properties of YAP, a candidate oncogene on the chromosome 11q22 amplicon , 2006, Proceedings of the National Academy of Sciences.

[29]  M. Henriksson,et al.  The Myc oncoprotein as a therapeutic target for human cancer. , 2006, Seminars in cancer biology.

[30]  Giacomo Finocchiaro,et al.  Myc-binding-site recognition in the human genome is determined by chromatin context , 2006, Nature Cell Biology.

[31]  M. Cole,et al.  A Conserved Myc Protein Domain, MBIV, Regulates DNA Binding, Apoptosis, Transformation, and G2 Arrest , 2006, Molecular and Cellular Biology.

[32]  Bruno Amati,et al.  Oncogenic activity of the c-Myc protein requires dimerization with Max , 1993, Cell.

[33]  L. Penn,et al.  Negative autoregulation of c‐myc transcription. , 1990, The EMBO journal.

[34]  J. Parsons,et al.  MC29 deletion mutants which fail to transform chicken macrophages are competent for transformation of quail macrophages , 1987, Journal of virology.

[35]  H. Varmus,et al.  Definition of regions in human c-myc that are involved in transformation and nuclear localization , 1987, Molecular and cellular biology.

[36]  J. Parsons,et al.  Site-directed mutagenesis of the gag-myc gene of avian myelocytomatosis virus 29: biological activity and intracellular localization of structurally altered proteins , 1986, Journal of virology.

[37]  Takashi Aoi,et al.  Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts , 2008, Nature Biotechnology.