Increased carotid intima-media thickness in children-adolescents, and young adults with a parental history of premature myocardial infarction.

AIMS The present study was designed to test whether early carotid structural changes are demonstrable (by high resolution B-mode ultrasound) in children, adolescents and young adults with a history of premature parental myocardial infarction. METHODS AND RESULTS One hundred and fourteen healthy young (5 to 30 years) subjects with a parental history of premature myocardial infarction and 114 age- and sex-matched control subjects were enrolled in the study. They were divided into two age groups: children and adolescents (age 5 to 18 years) (54 individuals with a parental history of premature myocardial infarction and their control subjects; mean age 12.8+/-3.8 years) and young adults (age 19 to 30 years) (60 individuals with a parental history and their controls; mean age 23.8+/-3.3 years). All subjects underwent high resolution B-mode ultrasonographic evaluation of common carotid artery intima-media thickness. Lipid profile, resting blood pressure, body mass index and smoking status were also evaluated. In both age groups, compared to controls, subjects with a parental history of premature myocardial infarction had increased intima-media thickness of common carotid arteries (mean of combined sites: age 5-18 years: 0.45+/-0.076 mm vs 0.40+/-0.066 mm in controls, P=0.008; age 19-30 years: 0.48+/-0.077 mm vs 0.45+/-0.078 mm in controls,P =0.007) Offspring of coronary patients showed an unfavourable lipid profile, however, the association between a parental history of premature myocardial infarction and carotid intima-media thickness was independent of lipids, apolipoproteins and other traditional risk factors. CONCLUSIONS Vascular structural changes associated with a parental history of premature myocardial infarction are already detectable in childhood and adolescence and occur independently of several traditional cardiovascular risk factors.

[1]  C. Held,et al.  Prognostic implications of intima-media thickness and plaques in the carotid and femoral arteries in patients with stable angina pectoris. , 2001, European heart journal.

[2]  M. Trevisan,et al.  Arterial abnormalities in the offspring of patients with premature myocardial infarction. , 2000, The New England journal of medicine.

[3]  Eary,et al.  CAROTID-ARTERY INTIMA AND MEDIA THICKNESS AS A RISK FACTOR FOR MYOCARDIAL INFARCTION AND STROKE IN OLDER ADULTS , 2000 .

[4]  B. McManus,et al.  Neonatal intima formation in the human coronary artery. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[5]  J. Beilby,et al.  Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS) , 1999, Circulation.

[6]  MahmoudZureik,et al.  Differential Association of Common Carotid Intima-Media Thickness and Carotid Atherosclerotic Plaques With Parental History of Premature Death From Coronary Heart Disease , 1999 .

[7]  P. Touboul,et al.  Differential association of common carotid intima-media thickness and carotid atherosclerotic plaques with parental history of premature death from coronary heart disease : the EVA study. , 1999, Arteriosclerosis, thrombosis, and vascular biology.

[8]  R. Kronmal,et al.  Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. , 1999, The New England journal of medicine.

[9]  P. Talmud,et al.  Lipoprotein lipase gene variation is associated with a paternal history of premature coronary artery disease and fasting and postprandial plasma triglycerides: the European Atherosclerosis Research Study (EARS). , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[10]  E. Boerwinkle,et al.  Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. , 1997, Circulation.

[11]  J L Witztum,et al.  Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions. , 1997, The Journal of clinical investigation.

[12]  J. Deanfield,et al.  Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease. , 1997, Circulation.

[13]  M. Siimes,et al.  Cholesterol and carotid artery wall in children and adolescents with familial hypercholesterolaemia: a controlled study by ultrasound , 1997, Acta paediatrica.

[14]  L. Peltonen,et al.  How to tackle genetic loci predisposing to atherosclerosis? , 1997, Current opinion in lipidology.

[15]  S. Tonstad,et al.  Risk factors related to carotid intima-media thickness and plaque in children with familial hypercholesterolemia and control subjects. , 1996, Arteriosclerosis, thrombosis, and vascular biology.

[16]  E. Vartiainen,et al.  Parental history of premature coronary heart disease: an independent risk factor of myocardial infarction. , 1996, Journal of clinical epidemiology.

[17]  M. Bond,et al.  Association of coronary disease with segment-specific intimal-medial thickening of the extracranial carotid artery. , 1995, Circulation.

[18]  D. Wilcken,et al.  Angiotensin-converting enzyme genotype in children and coronary events in their grandparents. , 1995, Circulation.

[19]  J. Strong.  Natural history and risk factors for early human atherogenesis. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. , 1995, Clinical chemistry.

[20]  A. Hofman,et al.  Common carotid intima-media thickness and lower extremity arterial atherosclerosis. The Rotterdam Study. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[21]  D. Celermajer,et al.  Endothelium-dependent dilation in the systemic arteries of asymptomatic subjects relates to coronary risk factors and their interaction. , 1994, Journal of the American College of Cardiology.

[22]  A. Di Costanzo,et al.  Increased intima-media thickness of the common carotid artery in hypercholesterolemic children. , 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

[23]  A. Folsom,et al.  Association of hemostatic variables with prevalent cardiovascular disease and asymptomatic carotid artery atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. , 1993, Arteriosclerosis and thrombosis : a journal of vascular biology.

[24]  J. Kaprio,et al.  Intimal Thickening of the Coronary Arteries in Infants in Relation to Family History of Coronary Artery Disease , 1993, Circulation.

[25]  S. Srinivasan,et al.  Racial (Black‐White) Differences in Serum Lipoprotein (a) Distribution and Its Relation to Parental Myocardial Infarction in Children: Bogalusa Heart Study , 1991, Circulation.

[26]  Gerald S. Berenson,et al.  Autopsy Studies in United States Children and Adolescents a , 1991 .

[27]  W. Kannel,et al.  Parental history is an independent risk factor for coronary artery disease: the Framingham Study. , 1990, American heart journal.

[28]  P Pignoli,et al.  Intimal plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. , 1986, Circulation.

[29]  C. Shear,et al.  The relation of apolipoproteins A-I and B in children to parental myocardial infarction. , 1986, The New England journal of medicine.