Maxillary Osteosarcomas after Irradiation for Nasopharyngeal Carcinoma: A Case Report and Review of the Lilerrature

Radiation induced sarcomas (RIO) are rare tumors that develop after a latent period after radiation, within the field of radiation. A 22-year-old woman with a history of nasopharyngeal carcinoma, treated with standard neo-adjuvant chemotherapy followed by irradiation. 4 years after, computed tomography showed an extensive loco regional lesion of the left maxilla. Biopsy revealed high-grade osteosarcomas. The patient was treated by chemotherapy. There was no response and the tumor remained unresectable. RIO is particular form of osteosarcomas; diagnosis and treatment are still a dilemma.

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