This paper documents recent advances of the SWENSE (Spectral Wave Explicit Navier-Stokes Equations) approach, a method for simulating fully nonlinear wave-body interactions including viscous effects. The methods efficiently combines a fully nonlinear potential flow description of undisturbed wave systems with a modified set of RANS with free surface equations accounting for the interaction with a ship or marine structure. Arbitrary incident wave systems may be described, including regular, irregular waves, multidirectional waves, focused wave events, etc. The model may be fixed or moving with arbitrary speed and 6 degrees of freedom motion. The extension of the SWENSE method to 6 DOF simulations in irregular waves as well as to manoeuvring simulations in waves are discussed in this paper. Different illlustative simulations are presented and discussed. Results of the present approach compare favorably with available reference results.Copyright © 2008 by ASME