Preferential binding of a kinesin-1 motor to GTP-tubulin–rich microtubules underlies polarized vesicle transport

The high affinity of KIF5 for microtubules rich in GTP-tubulin results in polarized motor protein accumulation at axonal tips in neurons and may underlie polarized vesicle transport.

[1]  A. Hoenger,et al.  GTPγS microtubules mimic the growing microtubule end structure recognized by end-binding proteins (EBs) , 2011, Proceedings of the National Academy of Sciences.

[2]  Yosuke Tanaka,et al.  Molecular Motors in Neurons: Transport Mechanisms and Roles in Brain Function, Development, and Disease , 2010, Neuron.

[3]  J. Garrido,et al.  Impaired Function of HDAC6 Slows Down Axonal Growth and Interferes with Axon Initial Segment Development , 2010, PloS one.

[4]  David N. Mastronarde,et al.  ER sliding dynamics and ER–mitochondrial contacts occur on acetylated microtubules , 2010, The Journal of cell biology.

[5]  S. Kaech,et al.  Posttranslational Modifications of Tubulin and the Polarized Transport of Kinesin-1 in Neurons , 2010, Molecular biology of the cell.

[6]  A. Hyman,et al.  EB1 Recognizes the Nucleotide State of Tubulin in the Microtubule Lattice , 2009, PloS one.

[7]  D. McEwen,et al.  Single Molecule Imaging Reveals Differences in Microtubule Track Selection Between Kinesin Motors , 2009, PLoS biology.

[8]  M. Setou,et al.  Tubulin tyrosination navigates the kinesin-1 motor domain to axons , 2009, Nature Neuroscience.

[9]  A. Andrieux,et al.  Tubulin Tyrosination Is Required for the Proper Organization and Pathfinding of the Growth Cone , 2009, PloS one.

[10]  Mike Heilemann,et al.  Multicolor photoswitching microscopy for subdiffraction-resolution fluorescence imaging , 2009, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

[11]  M. Poo,et al.  A Selective Filter for Cytoplasmic Transport at the Axon Initial Segment , 2009, Cell.

[12]  Hari Shroff,et al.  Photoactivated Localization Microscopy (PALM) of Adhesion Complexes , 2008, Current protocols in cell biology.

[13]  Franck Perez,et al.  Detection of GTP-Tubulin Conformation in Vivo Reveals a Role for GTP Remnants in Microtubule Rescues , 2008, Science.

[14]  Dawen Cai,et al.  Tubulin modifications and their cellular functions. , 2008, Current opinion in cell biology.

[15]  Dawen Cai,et al.  Microtubule Acetylation Promotes Kinesin-1 Binding and Transport , 2006, Current Biology.

[16]  J. Lippincott-Schwartz,et al.  Imaging Intracellular Fluorescent Proteins at Nanometer Resolution , 2006, Science.

[17]  B. Schnapp,et al.  A Change in the Selective Translocation of the Kinesin-1 Motor Domain Marks the Initial Specification of the Axon , 2006, Neuron.

[18]  Nobutaka Hirokawa,et al.  Molecular motors and mechanisms of directional transport in neurons , 2005, Nature Reviews Neuroscience.

[19]  E. Muto,et al.  Long-range cooperative binding of kinesin to a microtubule in the presence of ATP , 2005, The Journal of cell biology.

[20]  A. Miyawaki,et al.  Regulated Fast Nucleocytoplasmic Shuttling Observed by Reversible Protein Highlighting , 2004, Science.

[21]  Ryo Nitta,et al.  KIF1A Alternately Uses Two Loops to Bind Microtubules , 2004, Science.

[22]  M. Castoldi,et al.  Purification of brain tubulin through two cycles of polymerization-depolymerization in a high-molarity buffer. , 2003, Protein expression and purification.

[23]  N. Hirokawa,et al.  Microtubules provide directional cues for polarized axonal transport through interaction with kinesin motor head , 2003, The Journal of cell biology.

[24]  N. Hirokawa,et al.  Kinesin Superfamily Protein 2A (KIF2A) Functions in Suppression of Collateral Branch Extension , 2003, Cell.

[25]  E. Mandelkow,et al.  Nucleotide‐induced conformations in the neck region of dimeric kinesin , 2003, The EMBO journal.

[26]  E. Mandelkow,et al.  Structure of a fast kinesin: implications for ATPase mechanism and interactions with microtubules , 2001, The EMBO journal.

[27]  N. Hirokawa,et al.  Defects in Axonal Elongation and Neuronal Migration in Mice with Disrupted tau and map1b Genes , 2000, The Journal of cell biology.

[28]  G. Banker,et al.  The Role of Selective Transport in Neuronal Protein Sorting , 2000, Neuron.

[29]  N. Hirokawa,et al.  Mechanism of the single-headed processivity: diffusional anchoring between the K-loop of kinesin and the C terminus of tubulin. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Ronald D. Vale,et al.  Single-molecule analysis of kinesin motility reveals regulation by the cargo-binding tail domain , 1999, Nature Cell Biology.

[31]  J. Howard,et al.  Kinesin’s tail domain is an inhibitory regulator of the motor domain , 1999, Nature Cell Biology.

[32]  Anthony A. Hyman,et al.  Structural changes at microtubule ends accompanying GTP hydrolysis: Information from a slowly hydrolyzable analogue of GTP, guanylyl (α,β)methylenediphosphonate , 1998 .

[33]  N. Hirokawa,et al.  Visualization of the Dynamics of Synaptic Vesicle and Plasma Membrane Proteins in Living Axons , 1998, The Journal of cell biology.

[34]  S. Rosenfeld,et al.  Equilibrium Studies of Kinesin-Nucleotide Intermediates (*) , 1996, The Journal of Biological Chemistry.

[35]  A. M. Gordon,et al.  Kinetic Studies of Calcium Binding to the Regulatory Site of Troponin C from Cardiac Muscle (*) , 1996, The Journal of Biological Chemistry.

[36]  R. Vale,et al.  Tubulin GTP hydrolysis influences the structure, mechanical properties, and kinesin-driven transport of microtubules. , 1994, The Journal of biological chemistry.

[37]  G. Banker,et al.  Intracellular organization of hippocampal neurons during the development of neuronal polarity , 1991, Journal of Cell Science.

[38]  G. Banker,et al.  Changes in microtubule polarity orientation during the development of hippocampal neurons in culture , 1989, The Journal of cell biology.

[39]  P. Hollenbeck.  The distribution, abundance and subcellular localization of kinesin , 1989, The Journal of cell biology.

[40]  A. Hyman,et al.  Structural changes at microtubule ends accompanying GTP hydrolysis: information from a slowly hydrolyzable analogue of GTP, guanylyl (alpha,beta)methylenediphosphonate. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  T. Mitchison,et al.  Preparation and characterization of caged fluorescein tubulin. , 1998, Methods in enzymology.