Inhaler technique: facts and fantasies. A view from the Aerosol Drug Management Improvement Team (ADMIT)

Health professionals tasked with advising patients with asthma and chronic obstructive pulmonary disease (COPD) how to use inhaler devices properly and what to do about unwanted effects will be aware of a variety of commonly held precepts. The evidence for many of these is, however, lacking or old and therefore in need of re-examination. Few would disagree that facilitating and encouraging regular and proper use of inhaler devices for the treatment of asthma and COPD is critical for successful outcomes. It seems logical that the abandonment of unnecessary or ill-founded practices forms an integral part of this process: the use of inhalers is bewildering enough, particularly with regular introduction of new drugs, devices and ancillary equipment, without unnecessary and pointless adages. We review the evidence, or lack thereof, underlying ten items of inhaler ‘lore’ commonly passed on by health professionals to each other and thence to patients. The exercise is intended as a pragmatic, evidence-informed review by a group of clinicians with appropriate experience. It is not intended to be an exhaustive review of the literature; rather, we aim to stimulate debate, and to encourage researchers to challenge some of these ideas and to provide new, updated evidence on which to base relevant, meaningful advice in the future. The discussion on each item is followed by a formal, expert opinion by members of the ADMIT Working Group.

[1]  M. Everard,et al.  Factors affecting total and "respirable" dose delivered by a salbutamol metered dose inhaler. , 1995, Thorax.

[2]  C. Vogelmeier,et al.  Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma , 2007, Current medical research and opinion.

[3]  Prevention of exercise induced asthma by inhaled salmeterol xinafoate. , 1992, Archives of disease in childhood.

[4]  Double-blind trial comparing two dosage schedules of beclomethasone dipropionate aerosol in the treatment of chronic bronchial asthma. Preliminary report of the Brompton Hospital-Medical Research Council Collaborative Trial. , 1974, Lancet.

[5]  T. Battelino,et al.  Influence of anti-asthmatic medications on dental caries in children in Slovenia. , 2013, International journal of paediatric dentistry.

[6]  S. Pedersen,et al.  Fenoterol powder inhaler technique in children: influence of inspiratory flow rate and breath-holding. , 1986, European journal of respiratory diseases.

[7]  Gerald C. Smaldone,et al.  Drug Delivery to the Lung , 2001 .

[8]  J. L. Rau,et al.  The importance of nonelectrostatic materials in holding chambers for delivery of hydrofluoroalkane albuterol. , 2006, Respiratory care.

[9]  P. Jones,et al.  Single maintenance and reliever therapy (SMART) of asthma: a critical appraisal , 2010, Thorax.

[10]  S. Newman Spacer Devices for Metered Dose Inhalers , 2004, Clinical pharmacokinetics.

[11]  P. Barry,et al.  The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler. , 1995, British journal of clinical pharmacology.

[12]  J. Donohue,et al.  Accuracy of float testing for metered-dose inhaler canisters. , 2002, Journal of the American Pharmaceutical Association.

[13]  M. Newhouse,et al.  Optimal delivery of aerosols from metered dose inhalers. , 1981, Chest.

[14]  G. Crompton,et al.  Comparison of Pulmicort pMDI plus Nebuhaler and Pulmicort Turbuhaler in asthmatic patients with dysphonia. , 2000, Respiratory medicine.

[15]  Marco Lodi,et al.  Inhaler mishandling remains common in real life and is associated with reduced disease control. , 2011, Respiratory medicine.

[16]  M Kaila,et al.  A 10 year asthma programme in Finland: major change for the better , 2006, Thorax.

[17]  D. Postma,et al.  Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex , 2005, Thorax.

[18]  J. Oppenheimer,et al.  The misconception of using floating patterns as an accurate means of measuring the contents of metered-dose inhaler devices. , 2001, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[19]  Satisfacción y preferencia del paciente asmático por los dispositivos de inhalación. Aplicación del FSI-10 , 2008 .

[20]  B. Monz,et al.  Development and Validation of a Patient Satisfaction and Preference Questionnaire for Inhalation Devices , 2005, Treatments in respiratory medicine.

[21]  G. Crompton,et al.  Beclomethasone dipropionate aerosol and oropharyngeal candidiasis. , 1976, British journal of diseases of the chest.

[22]  L. Borgström,et al.  Lung deposition of budesonide in asthmatics: a comparison of different formulations , 1998 .

[23]  L. Borgström,et al.  The effects of static charge in spacer devices on glucocorticosteroid aerosol deposition in asthmatic patients. , 1998, The European respiratory journal.

[24]  J. Dubus,et al.  Electrostatic charge on spacer devices and salbutamol response in young children. , 2003, International journal of pharmaceutics.

[25]  C. Rand,et al.  Noncompliance and treatment failure in children with asthma. , 1996, The Journal of allergy and clinical immunology.

[26]  G K Crompton,et al.  Problems patients have using pressurized aerosol inhalers. , 1982, European journal of respiratory diseases. Supplement.

[27]  R. D. de Haan,et al.  Predictors of incorrect inhalation technique in patients with asthma or COPD: a study using a validated videotaped scoring method. , 2010, Journal of aerosol medicine and pulmonary drug delivery.

[28]  J. J. Klein,et al.  Multiple inhalers confuse asthma patients. , 1999, The European respiratory journal.

[29]  Hak-Kim Chan,et al.  The role of particle properties in pharmaceutical powder inhalation formulations. , 2002, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[30]  E. Wu,et al.  Therapy persistence and adherence in patients with chronic obstructive pulmonary disease: multiple versus single long-acting maintenance inhalers , 2011, Journal of medical economics.

[31]  G. Crompton,et al.  Inappropriate inhaler use: assessment of use and patient preference of seven inhalation devices. EDICI. , 2000, Respiratory medicine.

[32]  J. J. Klein,et al.  Comparison of a new multidose powder inhaler (Diskus/Accuhaler) and the Turbuhaler regarding preference and ease of use. , 1998, The Journal of asthma : official journal of the Association for the Care of Asthma.

[33]  G. Waterer,et al.  Reducing electrostatic charge on spacer devices and bronchodilator response. , 2000, British journal of clinical pharmacology.

[34]  S. Julious,et al.  Assessing fullness of asthma patients' aerosol inhalers. , 1994, The British journal of general practice : the journal of the Royal College of General Practitioners.

[35]  A. Weinstein When should your asthmatic patients refill their MDI propelled with chlorofluorocarbons? , 1998, Delaware medical journal.

[36]  P. Anderson,et al.  Importance of inhaler-device satisfaction in asthma treatment: Real-world observations of physician-observed compliance and clinical/patient-reported outcomes , 2011, Advances in therapy.

[37]  E. McKnight,et al.  Asthma patients' inability to use a pressurised metered-dose inhaler (pMDI) correctly correlates with poor asthma control as defined by the Global Initiative for Asthma (GINA) strategy: a retrospective analysis , 2013, Primary care respiratory journal : journal of the General Practice Airways Group.

[38]  H. Kotaki,et al.  [Effects of mouth wash on the removing beclomethasone dipropionate delivered by pressurized aerosol metered-dose inhaler in the mouth]. , 1999, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

[39]  R. Horne Compliance, adherence, and concordance: implications for asthma treatment. , 2006, Chest.

[40]  B. Chipps,et al.  Dose counting and the use of pressurized metered-dose inhalers: running on empty. , 2006, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[41]  G. Rachelefsky,et al.  Impact of inhaled corticosteroid-induced oropharyngeal adverse events: results from a meta-analysis. , 2007, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[42]  J. Learmonth The Doctor's Mission , 1930, The Lancet.

[43]  D. Williams,et al.  Problems in assessing contents of metered dose inhalers. , 1993, BMJ.

[44]  H. Chan,et al.  Influence of Humidity on the Electrostatic Charge and Aerosol Performance of Dry Powder Inhaler Carrier based Systems , 2007, Pharmaceutical Research.

[45]  D. Pavia,et al.  Simple Instructions for using Pressurized Aerosol Bronchodilators1 , 1980, Journal of the Royal Society of Medicine.

[46]  R Horne,et al.  Compliance in asthma. , 1999, Respiratory medicine.

[47]  J. Mitchell,et al.  Do we always need computed tomography to detect and treat parapneumonic pleural effusion? , 2012, European Respiratory Journal.

[48]  Richard B. Reilly,et al.  An Acoustic-Based Method to Detect and Quantify the Effect of Exhalation into a Dry Powder Inhaler. , 2015, Journal of aerosol medicine and pulmonary drug delivery.

[49]  S. Colman,et al.  Comparing COPD treatment: nebulizer, metered dose inhaler, and concomitant therapy. , 2007, The American journal of medicine.

[50]  Victor C. Strasburger,et al.  Review and Recommendations , 1983 .

[51]  A. Smith,et al.  Childhood asthma and dental erosion. , 2000, ASDC journal of dentistry for children.

[52]  J. Thompson,et al.  A multicentre comparison of the efficacy of terbutaline Turbuhaler and salbutamol pressurized metered dose inhaler in hot, humid regions. , 1994, The European respiratory journal.

[53]  T. Iga,et al.  Kinetic analysis of effects of mouth washing on removal of drug residues following inhalation of fluticasone propionate dry powder. , 2007, Biological & pharmaceutical bulletin.

[54]  M. Burns,et al.  Case-Control Study , 2020, Definitions.

[55]  S. Larsson,et al.  Clinical consequences of inadequate inhalation technique in asthma therapy. , 1987, European journal of respiratory diseases.

[56]  W. Hop,et al.  Variability of aerosol delivery via spacer devices in young asthmatic children in daily life. , 1999, The European respiratory journal.

[57]  J A Anderson,et al.  Adherence to inhaled therapy, mortality and hospital admission in COPD , 2009, Thorax.

[58]  M. Molimard How to achieve good compliance and adherence with inhalation therapy , 2005, Current medical research and opinion.

[59]  H. Okamoto,et al.  Effects of surface processing of lactose carrier particles on dry powder inhalation properties of salbutamol sulfate. , 2004, Chemical & pharmaceutical bulletin.

[60]  F. Allaert,et al.  Improved asthma control with breath-actuated pressurized metered dose inhaler (pMDI): the SYSTER survey. , 2009, European review for medical and pharmacological sciences.

[61]  S. Bosnic-Anticevich,et al.  Improved asthma outcomes with a simple inhaler technique intervention by community pharmacists. , 2007, The Journal of allergy and clinical immunology.

[62]  Monika Chmielewska,et al.  Dysphonia associated with the use of inhaled corticosteroids , 2015, Current opinion in otolaryngology & head and neck surgery.

[63]  Absence of gargling affects topical adverse symptoms caused by inhaled corticosteroids in females , 2014, The Journal of asthma : official journal of the Association for the Care of Asthma.

[64]  H. Chan,et al.  Effect of Relative Humidity on the Electrostatic Charge Properties of Dry Powder Inhaler Aerosols , 2008, Pharmaceutical Research.

[65]  J. Toogood,et al.  Candidiasis and dysphonia complicating beclomethasone treatment of asthma. , 1980, The Journal of allergy and clinical immunology.

[66]  H. Okamoto,et al.  Effect of surface layering time of lactose carrier particles on dry powder inhalation properties of salbutamol sulfate. , 2004, Chemical & pharmaceutical bulletin.

[67]  S. Newman,et al.  The effect of handling techniques on electrostatic charge on spacer devices : a correlation with in vitro particle size analysis , 1996 .

[68]  B. Meakin,et al.  Effect of exposure to humidity on terbutaline delivery from turbuhaler dry power inhalation devices. , 1993, The European respiratory journal.

[69]  S. Pedersen Optimal use of tube spacer aerosols in asthmatic children , 1985, Clinical allergy.

[70]  E. Dağlı,et al.  Inhaler medicament effects on saliva and plaque pH in asthmatic children. , 1998, The Journal of clinical pediatric dentistry.

[71]  K Colón,et al.  Running on empty. , 1996, Minnesota medicine.

[72]  Iman A Basheti,et al.  Checklists for Powder Inhaler Technique: A Review and Recommendations , 2014, Respiratory Care.

[73]  A. Lippman Adherence to medication. , 2005, The New England journal of medicine.

[74]  J. Fonseca,et al.  Inhaler devices in asthma and COPD--an assessment of inhaler technique and patient preferences. , 2014, Respiratory medicine.

[75]  Virendra Singh,et al.  Evaluation of cariogenic potential of dry powder inhalers: A case-control study , 2013, Lung India : official organ of Indian Chest Society.

[76]  D. Pavia,et al.  Effects of various inhalation modes on the deposition of radioactive pressurized aerosols. , 1982, European journal of respiratory diseases. Supplement.

[77]  H. Chrystyn,et al.  Investigations of an optimal inhaler technique with the use of urinary salbutamol excretion as a measure of relative bioavailability to the lung. , 1993, Thorax.

[78]  B. Rubin,et al.  How do patients determine that their metered-dose inhaler is empty? , 2004, Chest.

[79]  [Assessment of patient satisfaction and preferences with inhalers in asthma with the FSI-10 Questionnaire]. , 2008, Archivos de bronconeumologia.

[80]  N Roche,et al.  Misuse of corticosteroid metered-dose inhaler is associated with decreased asthma stability , 2002, European Respiratory Journal.

[81]  L. Borgström,et al.  An in vivo and in vitro comparison of two powder inhalers following storage at hot/humid conditions. , 2005, Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine.

[82]  P. Daley-Yates,et al.  Beclomethasone dipropionate: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in man. , 2001, British journal of clinical pharmacology.

[83]  G. Colice,et al.  Withdrawal of albuterol inhalers containing chlorofluorocarbon propellants. , 2007, The New England journal of medicine.

[84]  J. L. Rau,et al.  Device selection and outcomes of aerosol therapy: Evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology. , 2005, Chest.

[85]  S. Pedersen,et al.  How to use a rotahaler. , 1986, Archives of disease in childhood.

[86]  Christine C Johnson,et al.  Relationship between adherence to inhaled corticosteroids and poor outcomes among adults with asthma. , 2004, The Journal of allergy and clinical immunology.

[87]  A. Burls Critical appraisal , 2016, Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists.

[88]  M. Newhouse,et al.  Response of asthmatic patients to fenoterol inhalation: A method of quantifying the airway bronchodilator dose , 1978, Clinical pharmacology and therapeutics.

[89]  J. Oppenheimer Device Selection and Outcomes of Aerosol Therapy: Evidence-Based Guidelines , 2006 .

[90]  C. Vogelmeier,et al.  Budesonide/formoterol maintenance and reliever therapy: a new treatment approach for adult patients with asthma. , 2008, Current medical research and opinion.

[91]  P. Royall,et al.  Differences in physical chemistry and dissolution rate of solid particle aerosols from solution pressurised inhalers. , 2014, International journal of pharmaceutics.

[92]  Jolyon P Mitchell,et al.  Valved holding chambers (VHCs) for use with pressurised metered-dose inhalers (pMDIs): a review of causes of inconsistent medication delivery. , 2007, Primary care respiratory journal : journal of the General Practice Airways Group.

[93]  Robert N. Stavins,et al.  ENVIRONMENTAL REGULATION IN THE 1990 S : A RETROSPECTIVE ANALYSIS , 2003 .

[94]  J. Shuster,et al.  Lung bioavailability of hydrofluoroalkane fluticasone in young children when delivered by an antistatic chamber/mask. , 2006, The Journal of pediatrics.

[95]  J. Vestbo,et al.  Inhaled corticosteroids and decline of lung function in community residents with asthma , 2006, Thorax.

[96]  P. Lawford,et al.  Pressurized bronchodilator aerosol technique: influence of breath-holding time and relationship of inhaler to the mouth. , 1982, British journal of diseases of the chest.

[97]  T. Ueda,et al.  Repeated Instruction on Inhalation Technique Improves Adherence to the Therapeutic Regimen in Asthma , 2010, The Journal of asthma : official journal of the Association for the Care of Asthma.

[98]  M. Metintaş,et al.  Oropharyngeal candidiasis with dry-powdered fluticasone propionate: 500 μg/day versus 200 μg/day , 2008 .

[99]  T. L. Rogers,et al.  Investigation of Some Commercially Available Spacer Devices for the Delivery of Glucocorticoid Steroids from a pMDI , 2001, Drug development and industrial pharmacy.

[100]  R. Simon,et al.  How patients determine when to replace their metered-dose inhalers. , 1995, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.