Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice

[1]  S. E. Aidy,et al.  Bacterial Metabolites Mirror Altered Gut Microbiota Composition in Patients with Parkinson's Disease , 2019 .

[2]  A. Salgado,et al.  Old and new challenges in Parkinson's disease therapeutics , 2017, Progress in Neurobiology.

[3]  Rob Knight,et al.  Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease , 2016, Cell.

[4]  K. Fassbender,et al.  Short chain fatty acids and gut microbiota differ between patients with Parkinson's disease and age-matched controls. , 2016, Parkinsonism & related disorders.

[5]  E. Masliah,et al.  Exposure to the Functional Bacterial Amyloid Protein Curli Enhances Alpha-Synuclein Aggregation in Aged Fischer 344 Rats and Caenorhabditis elegans , 2016, Scientific Reports.

[6]  C. Pellegrini,et al.  Alteration of colonic excitatory tachykininergic motility and enteric inflammation following dopaminergic nigrostriatal neurodegeneration , 2016, Journal of Neuroinflammation.

[7]  J. Błaszczyk.  Parkinson's Disease and Neurodegeneration: GABA-Collapse Hypothesis , 2016, Front. Neurosci..

[8]  K. Takeda,et al.  Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia , 2016, Nature.

[9]  S. Mazmanian,et al.  Gut biogeography of the bacterial microbiota , 2015, Nature Reviews Microbiology.

[10]  A. Shetty,et al.  Resveratrol Treatment after Status Epilepticus Restrains Neurodegeneration and Abnormal Neurogenesis with Suppression of Oxidative Stress and Inflammation , 2015, Scientific Reports.

[11]  P. Nighot,et al.  Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88 , 2015, The Journal of Immunology.

[12]  D. Kell,et al.  On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death. , 2015, Integrative biology : quantitative biosciences from nano to macro.

[13]  Senthil Manikandan Thirumanilayur Jayaraman,et al.  Purple Urine Bag Syndrome. , 2015, Journal of clinical and diagnostic research : JCDR.

[14]  P. Zunino,et al.  Role of Proteus mirabilis MR/P fimbriae and flagella in adhesion, cytotoxicity and genotoxicity induction in T24 and Vero cells. , 2015, Pathogens and disease.

[15]  A. Vakis,et al.  Infections in patients undergoing craniotomy: risk factors associated with post-craniotomy meningitis. , 2015, Journal of neurosurgery.

[16]  G. Núñez,et al.  Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury. , 2015, Immunity.

[17]  E. Cereda,et al.  Increased urinary indoxyl sulfate (indican): new insights into gut dysbiosis in Parkinson's disease. , 2015, Parkinsonism & related disorders.

[18]  M. Heymann,et al.  Structural alterations of the intestinal epithelial barrier in Parkinson’s disease , 2015, Acta neuropathologica communications.

[19]  E. Pekkonen,et al.  Gut microbiota are related to Parkinson's disease and clinical phenotype , 2015, Movement disorders : official journal of the Movement Disorder Society.

[20]  T. Baron,et al.  Early and Persistent Expression of Phosphorylated &agr;-Synuclein in the Enteric Nervous System of A53T Mutant Human &agr;-Synuclein Transgenic Mice , 2014, Journal of neuropathology and experimental neurology.

[21]  Jia-Yi Li,et al.  Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats , 2014, Acta Neuropathologica.

[22]  C. Jobin,et al.  Microbial imbalance and intestinal pathologies: connections and contributions , 2014, Disease Models & Mechanisms.

[23]  R. Bakay,et al.  Progression of intestinal permeability changes and alpha‐synuclein expression in a mouse model of Parkinson's disease , 2014, Movement disorders : official journal of the Movement Disorder Society.

[24]  Y. Pak,et al.  Effects of the root bark of Paeonia suffruticosa on mitochondria-mediated neuroprotection in an MPTP-induced model of Parkinson's disease. , 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[25]  J. Petrosino,et al.  Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders , 2013, Cell.

[26]  Johannes Kornhuber,et al.  A progressive dopaminergic phenotype associated with neurotoxic conversion of α-synuclein in BAC-transgenic rats. , 2013, Brain : a journal of neurology.

[27]  D. Munoz,et al.  Enteric alpha‐synuclein expression is increased in Parkinson's disease but not Alzheimer's disease , 2013, Movement disorders : official journal of the Movement Disorder Society.

[28]  D. Devos,et al.  Colonic inflammation in Parkinson's disease , 2013, Neurobiology of Disease.

[29]  V. Rathaur,et al.  Neonatal meningoventriculitis due to proteus mirabilis - a case report. , 2013, Journal of clinical and diagnostic research : JCDR.

[30]  E. Carboni,et al.  The MPTP/probenecid model of progressive Parkinson's disease. , 2013, Methods in molecular biology.

[31]  F. Micheli,et al.  Gastrointestinal manifestations in Parkinson’s disease: prevalence and occurrence before motor symptoms , 2013, Journal of Neurology.

[32]  H. Reichmann,et al.  Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice , 2012, Scientific Reports.

[33]  G. Paxinos,et al.  Paxinos and Franklin's the Mouse Brain in Stereotaxic Coordinates , 2012 .

[34]  M. Chesselet,et al.  Mice overexpressing wild‐type human alpha‐synuclein display alterations in colonic myenteric ganglia and defecation , 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[35]  C. Pothoulakis,et al.  Elevated lipopolysaccharide in the colon evokes intestinal inflammation, aggravated in immune modulator-impaired mice. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[36]  K. Shannon,et al.  Alpha‐synuclein in colonic submucosa in early untreated Parkinson's disease , 2012, Movement disorders : official journal of the Movement Disorder Society.

[37]  K. Shannon,et al.  Is alpha‐synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases , 2012, Movement disorders : official journal of the Movement Disorder Society.

[38]  M. Britschgi,et al.  Inflammation and α-Synuclein’s Prion-like Behavior in Parkinson's Disease—Is There a Link? , 2012, Molecular Neurobiology.

[39]  Jeffrey H. Kordower,et al.  Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson's Disease , 2011, PloS one.

[40]  F. Fornai,et al.  Parallel manifestations of neuropathologies in the enteric and central nervous systems , 2011, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[41]  T. Müller.  Motor complications, levodopa metabolism and progression of Parkinson's disease , 2011, Expert opinion on drug metabolism & toxicology.

[42]  P. Allen,et al.  Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease. , 2011, Cell host & microbe.

[43]  R. Alizadeh,et al.  Extraction, Purification and Characterization of Lipopolysaccharide from Escherichia coli and Salmonella typhi , 2011, Avicenna journal of medical biotechnology.

[44]  Maria Karlsson,et al.  Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. , 2010, Cell host & microbe.

[45]  M. Neunlist,et al.  Biopsable Neural Tissues: Toward New Biomarkers for Parkinson's Disease? , 2010, Front. Psychiatry.

[46]  R. Burke,et al.  Clinical progression in Parkinson disease and the neurobiology of axons , 2010, Annals of neurology.

[47]  Maria T. Abreu,et al.  Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function , 2010, Nature Reviews Immunology.

[48]  S. Rehen,et al.  Murine Model for Parkinson's Disease: from 6-OH Dopamine Lesion to Behavioral Test , 2010, Journal of visualized experiments : JoVE.

[49]  D. Dickson,et al.  Neuropathology of non-motor features of Parkinson disease. , 2009, Parkinsonism & related disorders.

[50]  Jerrold R. Turner,et al.  Intestinal mucosal barrier function in health and disease , 2009, Nature Reviews Immunology.

[51]  E. Tolosa,et al.  A reassessment of risks and benefits of dopamine agonists in Parkinson's disease , 2009, The Lancet Neurology.

[52]  R. Gaykema,et al.  Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior , 2008, Brain, Behavior, and Immunity.

[53]  R. Dantzer,et al.  From inflammation to sickness and depression: when the immune system subjugates the brain , 2008, Nature Reviews Neuroscience.

[54]  E. Lai,et al.  Non-motor Symptoms of Parkinson's Disease , 2007 .

[55]  F. Crews,et al.  Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration , 2007, Glia.

[56]  S. Hazen,et al.  Metabolism of 3-Nitrotyrosine Induces Apoptotic Death in Dopaminergic Cells , 2006, The Journal of Neuroscience.

[57]  E. Kiyatkin,et al.  GABA, Not Glutamate, Controls the Activity of Substantia Nigra Reticulata Neurons in Awake, Unrestrained Rats , 2004, The Journal of Neuroscience.

[58]  W. Dauer,et al.  Parkinson's Disease Mechanisms and Models , 2003, Neuron.

[59]  Z. Kassim,et al.  Isolation of Proteus mirabilis from severe neonatal sepsis and central nervous system infection with extensive pneumocephalus , 2003, European Journal of Pediatrics.

[60]  H. Braak,et al.  Staging of brain pathology related to sporadic Parkinson’s disease , 2003, Neurobiology of Aging.

[61]  C. Whitfield,et al.  Lipopolysaccharide endotoxins. , 2002, Annual review of biochemistry.

[62]  D. Podolsky,et al.  Lipopolysaccharide Activates Distinct Signaling Pathways in Intestinal Epithelial Cell Lines Expressing Toll-Like Receptors1 , 2000, The Journal of Immunology.

[63]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[64]  M. Kagnoff,et al.  A distinct array of proinflammatory cytokines is expressed in human colon epithelial cells in response to bacterial invasion. , 1995, The Journal of clinical investigation.

[65]  E. Rietschel,et al.  Chemical structure of the lipid A component of the lipopolysaccharide from a Proteus mirabilis Re-mutant. , 1983, European journal of biochemistry.

[66]  L. Ng,et al.  Biochemical characteristics and identification of Enterobacteriaceae isolated from meats , 1981, Applied and environmental microbiology.