Curcumin induces apoptosis of multidrug-resistant human leukemia HL60 cells by complex pathways leading to ceramide accumulation.

[1]  M. Si,et al.  Reversion effects of curcumin on multidrug resistance of MNNG/HOS human osteosarcoma cells in vitro and in vivo through regulation of P‐glycoprotein , 2013, Chinese medical journal.

[2]  Umashankar Vetrivel,et al.  Modulation of multidrug resistance 1 expression and function in retinoblastoma cells by curcumin , 2013, Journal of pharmacology & pharmacotherapeutics.

[3]  S. Saddoughi,et al.  Diverse functions of ceramide in cancer cell death and proliferation. , 2013, Advances in cancer research.

[4]  E. Schuchman,et al.  Use of acid sphingomyelinase for cancer therapy. , 2013, Advances in cancer research.

[5]  Dong Xu,et al.  P-gp upregulation may be blocked by natural curcuminoids, a novel class of chemoresistance-preventing agent. , 2013, Molecular medicine reports.

[6]  M. Go,et al.  Curcumin Analogues with Potent and Selective Anti‐proliferative Activity on Acute Promyelocytic Leukemia: Involvement of Accumulated Misfolded Nuclear Receptor Co‐repressor (N‐CoR) Protein as a Basis for Selective Activity , 2012, ChemMedChem.

[7]  Faisal T Thayyullathil,et al.  Glutathione regulates caspase-dependent ceramide production and curcumin-induced apoptosis in human leukemic cells. , 2012, Free radical biology & medicine.

[8]  Jing Cao,et al.  GCS overexpression is associated with multidrug resistance of human HCT-8 colon cancer cells , 2012, Journal of experimental & clinical cancer research : CR.

[9]  K. Kwiatkowska,et al.  Cell surface ceramide controls translocation of transferrin receptor to clathrin-coated pits. , 2012, Cellular signalling.

[10]  Umashankar Vetrivel,et al.  In vitro and In silico studies on inhibitory effects of curcumin on multi drug resistance associated protein (MRP1) in retinoblastoma cells , 2012, Bioinformation.

[11]  Hui Sun,et al.  1-Phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP) facilitates curcumin-induced melanoma cell apoptosis by enhancing ceramide accumulation, JNK activation, and inhibiting PI3K/AKT activation , 2012, Molecular and Cellular Biochemistry.

[12]  M. Cabot,et al.  P-glycoprotein antagonists confer synergistic sensitivity to short-chain ceramide in human multidrug-resistant cancer cells. , 2011, Experimental cell research.

[13]  N. Škalko-Basnet,et al.  Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment , 2011, Molecules.

[14]  M. Cabot,et al.  Expression of P-glycoprotein in HeLa cells confers resistance to ceramide cytotoxicity. , 2010, International journal of oncology.

[15]  Hui Sun,et al.  C6 ceramide potentiates curcumin-induced cell death and apoptosis in melanoma cell lines in vitro , 2010, Cancer Chemotherapy and Pharmacology.

[16]  R. Jacobs,et al.  Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress. , 2010, Journal of oral science.

[17]  Faisal T Thayyullathil,et al.  Modulation of curcumin-induced Akt phosphorylation and apoptosis by PI3K inhibitor in MCF-7 cells. , 2010, Biochemical and biophysical research communications.

[18]  K. Schulze-Osthoff,et al.  Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death , 2010, Cell Death and Differentiation.

[19]  C. Giacomantonio,et al.  Curcumin-Induced Apoptosis in PC3 Prostate Carcinoma Cells Is Caspase-Independent and Involves Cellular Ceramide Accumulation and Damage to Mitochondria , 2010, Nutrition and cancer.

[20]  Y. Banno,et al.  Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin. , 2009, Biochimica et biophysica acta.

[21]  F. Russel,et al.  Involvement of VDAC, Bax and Ceramides in the Efflux of AIF from Mitochondria during Curcumin-Induced Apoptosis , 2009, PloS one.

[22]  Y. Hannun,et al.  Downregulation of neutral ceramidase by gemcitabine: Implications for cell cycle regulation. , 2009, Biochimica et biophysica acta.

[23]  B. Langlois,et al.  De novo ceramide synthesis is responsible for the anti-tumor properties of camptothecin and doxorubicin in follicular thyroid carcinoma. , 2009, The international journal of biochemistry & cell biology.

[24]  Faisal T Thayyullathil,et al.  Rapid reactive oxygen species (ROS) generation induced by curcumin leads to caspase-dependent and -independent apoptosis in L929 cells. , 2008, Free radical biology & medicine.

[25]  Xianlin Han,et al.  Differential regulation of sphingomyelin synthesis and catabolism in oligodendrocytes and neurons , 2008, Journal of neurochemistry.

[26]  A. Tarca,et al.  Suppression of sphingomyelin synthase 1 by small interference RNA is associated with enhanced ceramide production and apoptosis after photodamage. , 2008, Experimental cell research.

[27]  A. Look,et al.  Mutations in the neutral sphingomyelinase gene SMPD3 implicate the ceramide pathway in human leukemias. , 2008, Blood.

[28]  R. Planalp,et al.  Curcumin: From ancient medicine to current clinical trials , 2008, Cellular and Molecular Life Sciences.

[29]  B. Aggarwal,et al.  Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). , 2007, Free radical biology & medicine.

[30]  L. Ohlsson,et al.  Curcumin Decreases Acid Sphingomyelinase Activity in Colon Cancer Caco-2 Cells , 2007, Planta medica.

[31]  G. Dbaibo,et al.  Arsenic trioxide induces accumulation of cytotoxic levels of ceramide in acute promyelocytic leukemia and adult T-cell leukemia/lymphoma cells through de novo ceramide synthesis and inhibition of glucosylceramide synthase activity. , 2007, Haematologica.

[32]  M. Diederich,et al.  Curcumin regulates signal transducer and activator of transcription (STAT) expression in K562 cells. , 2006, Biochemical pharmacology.

[33]  Jing-Gung Chung,et al.  Curcumin-induced cell cycle arrest and apoptosis in human acute promyelocytic leukemia HL-60 cells via MMP changes and caspase-3 activation. , 2006, Anticancer research.

[34]  F. Tafesse,et al.  The Multigenic Sphingomyelin Synthase Family* , 2006, Journal of Biological Chemistry.

[35]  Michal Levy,et al.  nSMase2 activation and trafficking are modulated by oxidative stress to induce apoptosis. , 2006, Biochemical and biophysical research communications.

[36]  A. Gomez-Muñoz,et al.  Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells. , 2005, Carcinogenesis.

[37]  O. Cuvillier,et al.  Overcoming MDR-associated chemoresistance in HL-60 acute myeloid leukemia cells by targeting shingosine kinase-1 , 2006, Leukemia.

[38]  F. Sharom,et al.  The reconstituted P-glycoprotein multidrug transporter is a flippase for glucosylceramide and other simple glycosphingolipids. , 2005, The Biochemical journal.

[39]  A. Giuliano,et al.  Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. , 2005, Cancer research.

[40]  G. Dbaibo,et al.  Ceramide and glutathione define two independently regulated pathways of cell death initiated by p53 in Molt-4 leukaemia cells. , 2003, The Biochemical journal.

[41]  Alexei Degterev,et al.  A decade of caspases , 2003, Oncogene.

[42]  Y. Hannun,et al.  Biochemical Properties of Mammalian Neutral Sphingomyelinase2 and Its Role in Sphingolipid Metabolism* , 2003, The Journal of Biological Chemistry.

[43]  A. Schinkel,et al.  Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview. , 2003, Advanced drug delivery reviews.

[44]  T. Uchiyama,et al.  Possible role of ceramide as an indicator of chemoresistance: decrease of the ceramide content via activation of glucosylceramide synthase and sphingomyelin synthase in chemoresistant leukemia. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[45]  A. Hermetter,et al.  High-precision fluorescence assay for sphingomyelinase activity of isolated enzymes and cell lysates. , 2002, Journal of lipid research.

[46]  Gail Walker,et al.  Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes* , 2000, The Journal of Biological Chemistry.

[47]  A. Bielawska,et al.  Quantitative determination of ceramide using diglyceride kinase. , 2000, Methods in enzymology.

[48]  T. Uchiyama,et al.  Ceramide Generation in Nitric Oxide-induced Apoptosis , 1999, The Journal of Biological Chemistry.

[49]  A E Giuliano,et al.  Expression of Glucosylceramide Synthase, Converting Ceramide to Glucosylceramide, Confers Adriamycin Resistance in Human Breast Cancer Cells* , 1999, The Journal of Biological Chemistry.

[50]  S. Grant,et al.  The role of ceramide in the cellular response to cytotoxic agents. , 1998, Current opinion in oncology.

[51]  Y. Hannun,et al.  Glutathione Regulation of Neutral Sphingomyelinase in Tumor Necrosis Factor-α-induced Cell Death* , 1998, The Journal of Biological Chemistry.

[52]  D. D. Jones,et al.  An update of the enzymology and regulation of sphingomyelin metabolism. , 1990, Biochimica et biophysica acta.

[53]  G. R. Bartlett.  Phosphorus assay in column chromatography. , 1959, The Journal of biological chemistry.