The Genome of the Sea Urchin Strongylocentrotus purpuratus

We report the sequence and analysis of the 814-megabase genome of the sea urchin Strongylocentrotus purpuratus, a model for developmental and systems biology. The sequencing strategy combined whole-genome shotgun and bacterial artificial chromosome (BAC) sequences. This use of BAC clones, aided by a pooling strategy, overcame difficulties associated with high heterozygosity of the genome. The genome encodes about 23,300 genes, including many previously thought to be vertebrate innovations or known only outside the deuterostomes. This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes.

Andrew R. Jackson | R. F. Gray | Wendy S. Beane | Katherine M. Buckley | G. Weinstock | R. Gibbs | A. Cohen | E. Davidson | D. McClay | T. Lepage | J. Taylor | D. Muzny | M. Morgan | L. Nazareth | C. Kovar | A. Cree | H. Dinh | M. Gonzalez-Garay | A. Milosavljevic | D. Maglott | K. Pruitt | Yufeng Shen | J. Schein | E. Sodergren | V. Solovyev | J. Rast | P. Oliveri | C. Calestani | G. Amore | P. Lee | M. Arnone | R. Cameron | M. Marra | A. Mushegian | K. Worley | C. Elsik | A. Genevière | R. Satija | L. Lewis | T. Gaasterland | P. Kitts | X. Mu | M. Landrum | Geoffrey O. Okwuonu | S. Hines | S. Dugan-Rocha | George R. Miner | Rachel B Gill | I. Bosdet | K. Durbin | W. Hlavina | V. Sapojnikov | B. Gold | R. Hynes | S. Istrail | G. Wray | J. Hume | Sandy Lee | L. Pu | Rita A. Wright | V. Štolc | W. Tongprasit | G. Manning | R. Obar | C. T. Brown | J. Whittle | A. Mackey | J. Reese | M. Elphick | A. Poustka | D. Graur | D. Garfield | Q. Tu | Lan Zhang | Xingzhi Song | E. Brown | M. Scally | G. Matassi | Nansheng Chen | O. Ermolaeva | K. Peterson | S. Fugmann | J. Morales | M. Samanta | A. Souvorov | J. Goldstone | M. E. Hahn | J. Stegeman | E. Elhaik | L. Smith | Celina E. Juliano | Shu-Yu Wu | V. Vacquier | F. Lapraz | L. Duloquin | M. Goel | K. Foltz | J. Coffman | P. Cormier | J. Chacko | Clay Davis | S. Bell | F. Raible | K. Tessmar-Raible | A. Fernàndez-Guerra | R. Haygood | O. Fedrigo | Jerry Fowler | S. Yaguchi | Judith Hernandez | David Parker | W. Marzluff | S. Hussain | I. Gibbons | F. Rizzo | V. Cavalieri | K. M. Buckley | A. Locascio | D. Burgess | G. Wessel | B. Rossetti | Enrique Arboleda | R. Bellé | G. Moy | Anna T. Neill | R. Angerer | L. Angerer | R. Burke | M. Dean | C. Ettensohn | A. Hamdoun | W. Klein | R. Morris | M. Thorndyke | G. Hofmann | G. Panopoulou | Zheng Wei | C. A. Whittaker | A. Primus | T. Severson | M. Tong | C. Killian | B. Livingston | F. Wilt | N. Adams | S. Carbonneau | Rocky Cheung | B. Cosson | Jenifer C. Croce | Hemant Kelkar | O. Mulner-lorillon | A. Robertson | B. Cole | D. Epel | M. Howard-Ashby | E. Allgood | J. Cool | K. M. Judkins | S. McCafferty | A. Musante | A. Rawson | M. Hoffman | A. Leone | Stefan C. Materna | K. Bergeron | B. Brandhorst | K. Berney | D. Bottjer | E. Chow | Q. Yuan | S. Heesun | Michele K. Anderson | V. Brockton | T. Hibino | M. Loza-Coll | A. Majeske | Cynthia Messier | S. Nair | Z. Pancer | D. P. Terwilliger | C. Agca | A. Churcher | F. Hallböök | G. Humphrey | M. Idris | T. Kiyama | S. Liang | D. Mellott | G. Murray | R. Olinski | M. Rowe | D. Wang | K. Wilson | B. Galindo | H. Gunaratne | M. Kinukawa | M. Nomura | Michael Raisch | A. Reade | M. M. Roux | Jia L. Song | Yi-Hsien Su | Ian K. Townley | E. Voronina | J. Wong | M. Branno | Véronique Duboc | C. Flytzanis | C. Gache | Pedro Martinez | V. Matranga | R. Range | É. Röttinger | C. Bradham | C. Byrum | T. Glenn | Esther Miranda | R. Thomason | K. Walton | A. Wikramanayke | Ronghui Xu | Lili Chen | J. Nam | Joel W. S. Smith | Stacey M Curry | C. Hamilton | L. Jackson | A. Jolivet | R. Thorn | Kristin Tessmar-Raible | A. Fernandez-Guerra | J. Fowler | R. L. Morris | R. Bellé | P. Martinez | Lingling Pu | Xingzhi Song | Michael Dean | Alexander E. Primus | Bryan J. Cole | Meredith Howard-Ashby | Ekaterina Voronina | ling-ling Pu | R. P. Olinski | Shuguang Liang | D. Muzny | Francesca Rizzo | Rachel B. Gill | Véronique Duboc | A. P. Rawson | Virginia Brockton | Stacey M. Curry | Andrew Cree | Victor V. Solovyev | Xiuqian Mu | Anna Reade

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