eIF4E activity is regulated at multiple levels.

[1]  A E Willis,et al.  Translational control of growth factor and proto-oncogene expression. , 1999, The international journal of biochemistry & cell biology.

[2]  A. W. van der Velden,et al.  The role of the 5' untranslated region of an mRNA in translation regulation during development. , 1999, The international journal of biochemistry & cell biology.

[3]  L. Shantz,et al.  Translational regulation of ornithine decarboxylase and other enzymes of the polyamine pathway. , 1999, The international journal of biochemistry & cell biology.

[4]  L. McKendrick,et al.  Translation initiation factor 4E. , 1999, The international journal of biochemistry & cell biology.

[5]  A. Gingras,et al.  4E-BP3, a New Member of the Eukaryotic Initiation Factor 4E-binding Protein Family* , 1998, The Journal of Biological Chemistry.

[6]  A. Gingras,et al.  Cloning and Characterization of 4EHP, a Novel Mammalian eIF4E-related Cap-binding Protein* , 1998, The Journal of Biological Chemistry.

[7]  G. Scheper,et al.  Regulation of translation initiation factors by signal transduction. , 1998, European journal of biochemistry.

[8]  A. Gingras,et al.  Gastrin induces phosphorylation of eIF4E binding protein 1 and translation initiation of ornithine decarboxylase mRNA , 1998, Oncogene.

[9]  Jonathan A. Cooper,et al.  The Phosphorylation of Eukaryotic Initiation Factor eIF4E in Response to Phorbol Esters, Cell Stresses, and Cytokines Is Mediated by Distinct MAP Kinase Pathways* , 1998, The Journal of Biological Chemistry.

[10]  A. Gingras,et al.  The mRNA 5' cap-binding protein eIF4E and control of cell growth. , 1998, Current opinion in cell biology.

[11]  J. Downward Mechanisms and consequences of activation of protein kinase B/Akt. , 1998, Current opinion in cell biology.

[12]  S. Snyder,et al.  RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[13]  A. Gingras,et al.  4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway. , 1998, Genes & development.

[14]  J. Downward Lipid-Regulated Kinases: Some Common Themes at Last , 1998, Science.

[15]  M. Andjelkovic,et al.  Phosphorylation and activation of p70s6k by PDK1. , 1998, Science.

[16]  G. Welsh,et al.  Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase‐3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin , 1998, FEBS letters.

[17]  A. Gingras,et al.  4E binding proteins inhibit the translation factor eIF4E without folded structure. , 1998, Biochemistry.

[18]  N. Sonenberg,et al.  A Novel Functional Human Eukaryotic Translation Initiation Factor 4G , 1998, Molecular and Cellular Biology.

[19]  C. Proud,et al.  Heat Shock Increases the Association of Binding Protein-1 with Initiation Factor 4E* , 1997, The Journal of Biological Chemistry.

[20]  T. Haystead,et al.  The Mammalian Target of Rapamycin Phosphorylates Sites Having a (Ser/Thr)-Pro Motif and Is Activated by Antibodies to a Region near Its COOH Terminus , 1997, The Journal of Biological Chemistry.

[21]  D. Stumpo,et al.  Disruption of the Gene Encoding the Mitogen-regulated Translational Modulator PHAS-I in Mice* , 1997, The Journal of Biological Chemistry.

[22]  G. Thomas,et al.  TOR signalling and control of cell growth. , 1997, Current opinion in cell biology.

[23]  N. Sonenberg,et al.  Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A , 1997, Molecular and cellular biology.

[24]  M. Kasuga,et al.  Regulation of eIF-4E BP1 Phosphorylation by mTOR* , 1997, The Journal of Biological Chemistry.

[25]  S. R. Datta,et al.  Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery , 1997, Cell.

[26]  A. Gingras,et al.  Adenovirus infection inactivates the translational inhibitors 4E-BP1 and 4E-BP2. , 1997, Virology.

[27]  A. Gingras,et al.  The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k , 1997, Molecular and cellular biology.

[28]  J Downward,et al.  PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond. , 1997, Trends in biochemical sciences.

[29]  A. Gingras,et al.  Structure of translation factor elF4E bound to m7GDP and interaction with 4E-binding protein , 1997, Nature Structural Biology.

[30]  L. McKendrick,et al.  Involvement of Stress-activated Protein Kinase and p38/RK Mitogen-activated Protein Kinase Signaling Pathways in the Enhanced Phosphorylation of Initiation Factor 4E in NIH 3T3 Cells* , 1997, The Journal of Biological Chemistry.

[31]  Christine C. Hudson,et al.  Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. , 1997, Science.

[32]  G. Panayotou,et al.  Phosphoinositide 3-kinases: a conserved family of signal transducers. , 1997, Trends in biochemical sciences.

[33]  A. Gingras,et al.  Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP , 1997, Cell.

[34]  Steven A. Carr,et al.  Pyridinyl Imidazole Inhibitors of p38 Mitogen-activated Protein Kinase Bind in the ATP Site* , 1997, The Journal of Biological Chemistry.

[35]  R. Eisenman,et al.  Myc target genes. , 1997, Trends in biochemical sciences.

[36]  Jonathan A. Cooper,et al.  Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 , 1997, The EMBO journal.

[37]  Tony Hunter,et al.  MNK1, a new MAP kinase‐activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates , 1997, The EMBO journal.

[38]  T. Haystead,et al.  Identification of Phosphorylation Sites in the Translational Regulator, PHAS-I, That Are Controlled by Insulin and Rapamycin in Rat Adipocytes* , 1997, The Journal of Biological Chemistry.

[39]  M. Hoekstra Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family. , 1997, Current opinion in genetics & development.

[40]  N. Hay,et al.  The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. , 1997, Genes & development.

[41]  C. Berset,et al.  A novel inhibitor of cap‐dependent translation initiation in yeast: p20 competes with eIF4G for binding to eIF4E , 1997, The EMBO journal.

[42]  N. Sonenberg,et al.  A new translational regulator with homology to eukaryotic translation initiation factor 4G , 1997, The EMBO journal.

[43]  A. Gingras,et al.  Angiotensin II Stimulates Phosphorylation of the Translational Repressor 4E-binding Protein 1 by a Mitogen-activated Protein Kinase-independent Mechanism* , 1997, The Journal of Biological Chemistry.

[44]  A. Gingras,et al.  The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. , 1996, Oncogene.

[45]  N. Sonenberg,et al.  Translational control of programmed cell death: eukaryotic translation initiation factor 4E blocks apoptosis in growth-factor-restricted fibroblasts with physiologically expressed or deregulated Myc , 1996, Molecular and cellular biology.

[46]  J. Avruch,et al.  Sounding the Alarm: Protein Kinase Cascades Activated by Stress and Inflammation* , 1996, The Journal of Biological Chemistry.

[47]  An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. , 1996, Molecular and cellular biology.

[48]  C. Proud,et al.  Insulin‐stimulated phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway , 1996, FEBS Letters.

[49]  C. McGuigan,et al.  A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5' splice site. , 1996, Genes & development.

[50]  A. Gingras,et al.  Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[51]  R. Aebersold,et al.  Phosphorylation of eIF-4E on Serine 209 by Protein Kinase C Is Inhibited by the Translational Repressors, 4E-binding Proteins (*) , 1996, The Journal of Biological Chemistry.

[52]  C. Proud,et al.  Regulation of translation elongation factor‐2 by insulin via a rapamycin‐sensitive signalling pathway. , 1996, The EMBO journal.

[53]  A. Gingras,et al.  4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[54]  V. M. Pain,et al.  A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate (*) , 1996, The Journal of Biological Chemistry.

[55]  B. Carabello,et al.  Translational Initiation Factor eIF-4E , 1996, The Journal of Biological Chemistry.

[56]  H. O. Voorma,et al.  Phosphorylation state of the cap-binding protein eIF4E during viral infection. , 1996, Virology.

[57]  A. Depaoli-Roach,et al.  Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways (*) , 1996, The Journal of Biological Chemistry.

[58]  V. M. Pain Initiation of protein synthesis in eukaryotic cells. , 1996, European journal of biochemistry.

[59]  N. Sonenberg 8 mRNA 5′ Cap-binding Protein elF4E and Control of Cell Growth , 1996 .

[60]  G. Thomas,et al.  14 Ribosomal Protein S6 Phosphorylation and Signal Transduction , 1996 .

[61]  N. Sonenberg,et al.  1 Origins and Targets of Translational Control , 1996 .

[62]  J. Hershey,et al.  2 The Pathway and Mechanism of Eukaryotic Protein Synthesis , 1996 .

[63]  N. Sonenberg,et al.  Repression of cap‐dependent translation by 4E‐binding protein 1: competition with p220 for binding to eukaryotic initiation factor‐4E. , 1995, The EMBO journal.

[64]  S. Schreiber,et al.  PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints , 1995, Science.

[65]  R. Rhoads,et al.  Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases , 1995, The Journal of Biological Chemistry.

[66]  The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. , 1995, Molecular and cellular biology.

[67]  Joe D. Lewis,et al.  A cap-binding protein complex mediating U snRNA export , 1995, Nature.

[68]  A. Bridges,et al.  A synthetic inhibitor of the mitogen-activated protein kinase cascade. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[69]  P. Blackshear,et al.  Control of PHAS-I by Insulin in 3T3-L1 Adipocytes , 1995, The Journal of Biological Chemistry.

[70]  O. Hazeki,et al.  Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase. , 1995, Trends in biochemical sciences.

[71]  E. Goldsmith,et al.  How MAP Kinases Are Regulated (*) , 1995, The Journal of Biological Chemistry.

[72]  R. Rhoads,et al.  Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209 (*) , 1995, The Journal of Biological Chemistry.

[73]  P. Sarnow,et al.  Cap-independent translation and internal initiation of translation in eukaryotic cellular mRNA molecules. , 1995, Current topics in microbiology and immunology.

[74]  Jonathan A. Cooper,et al.  Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. , 1995, Current opinion in cell biology.

[75]  S. Shuman Capping enzyme in eukaryotic mRNA synthesis. , 1995, Progress in nucleic acid research and molecular biology.

[76]  N. Sonenberg,et al.  PHAS-I as a link between mitogen-activated protein kinase and translation initiation. , 1994, Science.

[77]  A. Gingras,et al.  Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function , 1994, Nature.

[78]  R. Rhoads,et al.  Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[79]  N. Sonenberg,et al.  Angiotensin II induces phosphorylation of eukaryotic protein synthesis initiation factor 4E in vascular smooth muscle cells. , 1994, The Journal of biological chemistry.

[80]  M. Tuite,et al.  Initiation factor eIF-4E of Saccharomyces cerevisiae. Distribution within the cell, binding to mRNA, and consequences of its overproduction. , 1994, The Journal of biological chemistry.

[81]  A. De Benedetti,et al.  Decreasing the level of translation initiation factor 4E with antisense rna causes reversal of ras‐mediated transformation and tumorigenesis of cloned rat embryo fibroblasts , 1993, International journal of cancer.

[82]  K. Isselbacher,et al.  Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[83]  R. Schneider,et al.  Modification of eukaryotic initiation factor 4F during infection by influenza virus , 1993, Journal of virology.

[84]  N. Sonenberg,et al.  A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[85]  N. Sonenberg,et al.  Regulation of translation initiation factor gene expression during human T cell activation. , 1992, The Journal of biological chemistry.

[86]  R. Rhoads,et al.  Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E. , 1992, The Journal of biological chemistry.

[87]  N. Sonenberg,et al.  The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts , 1992, Molecular and cellular biology.

[88]  N. Sonenberg,et al.  RNA unwinding in translation: assembly of helicase complex intermediates comprising eukaryotic initiation factors eIF-4F and eIF-4B , 1991, Molecular and cellular biology.

[89]  A. De Benedetti,et al.  Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F , 1991, Molecular and cellular biology.

[90]  N. Sonenberg,et al.  Modulation of the mitogenic activity of eukaryotic translation initiation factor-4E by protein kinase C. , 1991, The New biologist.

[91]  N. Sonenberg,et al.  Phosphorylation of eukaryotic translation initiation factor 4E is increased in Src-transformed cell lines , 1991, Molecular and cellular biology.

[92]  A. De Benedetti,et al.  Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[93]  N. Sonenberg,et al.  Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap , 1990, Nature.

[94]  M. Goebl,et al.  CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae , 1988, Molecular and cellular biology.

[95]  N. Sonenberg,et al.  Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis. , 1987, The Journal of biological chemistry.

[96]  J. Hershey,et al.  Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F. , 1987, The Journal of biological chemistry.

[97]  R. Rhoads,et al.  Immunological detection of the messenger RNA cap-binding protein. , 1985, The Journal of biological chemistry.

[98]  M. Morgan,et al.  New initiation factor activity required for globin mRNA translation. , 1983, The Journal of biological chemistry.

[99]  Michael R. Green,et al.  Human β-globin pre-mRNA synthesized in vitro is accurately spliced in xenopus oocyte nuclei , 1983, Cell.

[100]  N. Sonenberg,et al.  Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex. , 1982, The Journal of biological chemistry.

[101]  M. Morgan,et al.  Two forms of purified m7G-cap binding protein with different effects on capped mRNA translation in extracts of uninfected and poliovirus-infected HeLa cells. , 1981, The Journal of biological chemistry.

[102]  N. Sonenberg,et al.  Eukaryotic mRNA cap binding protein : Purification by affinity chromatography on Sepharose-coupled m 7 GDP ( 7-methylguanosine / eukaryotic initiation factors / protein synthesis ) , 2022 .

[103]  M. Morgan,et al.  Synthesis and translation of mRNA containing 5'-terminal 7-ethylguanosine cap. , 1979, The Journal of biological chemistry.

[104]  N. Sonenberg,et al.  A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[105]  R. Brooks Continuous protein synthesis is required to maintain the probability of entry into S phase , 1977, Cell.

[106]  Aaron J. Shatkin,et al.  5′-Terminal structure and mRNA stability , 1977, Nature.

[107]  A. Shatkin,et al.  Ribosome binding to reovirus mRNA in protein synthesis requires 5′ terminal 7-methylguanosine , 1975, Cell.

[108]  A. J. Shatkin,et al.  5′-Terminal 7-methylguanosine in eukaryotic mRNA is required for translation , 1975, Nature.