Genome Sequence of Francisella tularensis subspecies holarctica Strain FSC200, Isolated from a Child with Tularemia

ABSTRACT Here we report the complete, accurate 1.89-Mb genome sequence of Francisella tularensis subsp. holarctica strain FSC200, isolated in 1998 in the Swedish municipality Ljusdal, which is in an area where tularemia is highly endemic. This genome is important because strain FSC200 has been extensively used for functional and genetic studies of Francisella and is well-characterized.

[1]  E. Rudolf,et al.  Activation of B cell apoptotic pathways in the course of Francisella tularensis infection. , 2010, Microbial pathogenesis.

[2]  T. Minogue,et al.  Development of real-time PCR assays for the specific detection of Francisella tularensis ssp. tularensis, holarctica and mediaasiatica. , 2010, Molecular and cellular probes.

[3]  A. Sjöstedt,et al.  Discrimination of Human Pathogenic Subspecies of Francisella tularensis by Using Restriction Fragment Length Polymorphism , 2003, Journal of Clinical Microbiology.

[4]  M. Bhide,et al.  Molecular Method for Discrimination between Francisella tularensis and Francisella-Like Endosymbionts , 2008, Journal of Clinical Microbiology.

[5]  I-Min A. Chen,et al.  IMG ER: a system for microbial genome annotation expert review and curation , 2009, Bioinform..

[6]  E. Rudolf,et al.  Interaction of B cells with intracellular pathogen Francisella tularensis. , 2008, Microbial pathogenesis.

[7]  Mats Forsman,et al.  A Real-Time PCR Array for Hierarchical Identification of Francisella Isolates , 2009, PloS one.

[8]  T. Maier,et al.  Identification of Francisella tularensis by Whole-Cell Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry: Fast, Reliable, Robust, and Cost-Effective Differentiation on Species and Subspecies Levels , 2010, Journal of Clinical Microbiology.

[9]  Anders Sjöstedt,et al.  Resistance of Francisella tularensis Strains against Reactive Nitrogen and Oxygen Species with Special Reference to the Role of KatG , 2007, Infection and Immunity.

[10]  C. Robert,et al.  Rapid comparative genomic analysis for clinical microbiology: the Francisella tularensis paradigm. , 2008, Genome research.

[11]  P Green,et al.  Base-calling of automated sequencer traces using phred. II. Error probabilities. , 1998, Genome research.

[12]  M. Forsman,et al.  Evolution of Subspecies of Francisella tularensis , 2005, Journal of Bacteriology.

[13]  Erik Bäck,et al.  Landscape Epidemiology of Tularemia Outbreaks in Sweden , 2009, Emerging infectious diseases.

[14]  David A. D'Argenio,et al.  Large-insert genome analysis technology detects structural variation in Pseudomonas aeruginosa clinical strains from cystic fibrosis patients. , 2008, Genomics.

[15]  M. Forsman,et al.  Influence of nutrient status and grazing pressure on the fate of Francisella tularensis in lake water. , 2009, FEMS microbiology ecology.

[16]  Byron Gallis,et al.  Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains , 2007, Genome Biology.

[17]  J. Benach,et al.  GroEL and Lipopolysaccharide from Francisella tularensis Live Vaccine Strain Synergistically Activate Human Macrophages , 2010, Infection and Immunity.

[18]  Samuel I. Miller,et al.  Potential Source of Francisella tularensis Live Vaccine Strain Attenuation Determined by Genome Comparison , 2006, Infection and Immunity.

[19]  Christine Fong,et al.  Bioinformatics Applications Note Genome Analysis Pgat: a Multistrain Analysis Resource for Microbial Genomes , 2022 .

[20]  M. Šantić,et al.  Deletion of IglH in virulent Francisella tularensis subsp. holarctica FSC200 strain results in attenuation and provides protection against the challenge with the parental strain. , 2012, Microbes and infection.

[21]  D. Crane,et al.  Intracellular biology and virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages , 2009, Cellular microbiology.

[22]  A. Sjöstedt,et al.  Ciprofloxacin for treatment of tularemia in children , 2000, The Pediatric infectious disease journal.

[23]  A. Sjöstedt,et al.  Iron Content Differs between Francisella tularensis Subspecies tularensis and Subspecies holarctica Strains and Correlates to Their Susceptibility to H2O2-Induced Killing , 2010, Infection and Immunity.

[24]  P. Green,et al.  Base-calling of automated sequencer traces using phred. I. Accuracy assessment. , 1998, Genome research.

[25]  A. Sjöstedt,et al.  Extensive Allelic Variation among Francisella tularensis Strains in a Short-Sequence Tandem Repeat Region , 2001, Journal of Clinical Microbiology.

[26]  A. Charbit,et al.  Hfq, a Novel Pleiotropic Regulator of Virulence-Associated Genes in Francisella tularensis , 2009, Infection and Immunity.

[27]  Mats Forsman,et al.  Direct repeat‐mediated deletion of a type IV pilin gene results in major virulence attenuation of Francisella tularensis , 2006, Molecular microbiology.

[28]  J. Petersen,et al.  Genotyping of Francisella tularensis, the causative agent of tularemia. , 2010, Journal of AOAC International.