Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPK 2 but not AMPK 1

Kei Sakamoto, Elham Zarrinpashneh, Grant R. Budas, Anne-Catherine Pouleur, Anindya Dutta, Alan R. Prescott, Jean-Louis Vanoverschelde, Alan Ashworth, Aleksandar Jovanović, Dario R. Alessi, and Luc Bertrand Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dundee, United Kingdom; Division of Cardiology, School of Medicine, Université catholique de Louvain, Brussels, Belgium; Maternal and Child Health Sciences, Tayside Institute of Child Health, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom; The Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom; and Division of Cell Biology and Immunology, School of Life Sciences, University of Dundee, Dundee, United Kingdom

[1]  K. Nakao,et al.  Low-intensity contraction activates the alpha1-isoform of 5'-AMP-activated protein kinase in rat skeletal muscle. , 2006, American journal of physiology. Endocrinology and metabolism.

[2]  A. Means,et al.  The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases* , 2005, Journal of Biological Chemistry.

[3]  R. Heath,et al.  Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells. , 2005, Cell metabolism.

[4]  A. Edelman,et al.  Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase. , 2005, Cell metabolism.

[5]  Seung-Pyo Hong,et al.  Function of Mammalian LKB1 and Ca2+/Calmodulin-dependent Protein Kinase Kinase α as Snf1-activating Kinases in Yeast* , 2005, Journal of Biological Chemistry.

[6]  Kei Sakamoto,et al.  Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction , 2005, The EMBO journal.

[7]  L. Witters,et al.  Dual Mechanisms Regulating AMPK Kinase Action in the Ischemic Heart , 2005, Circulation research.

[8]  G. Lopaschuk,et al.  Myocardial Ischemia Differentially Regulates LKB1 and an Alternate 5′-AMP-activated Protein Kinase Kinase* , 2005, Journal of Biological Chemistry.

[9]  D. Hardie.  The AMP-activated protein kinase pathway – new players upstream and downstream , 2004, Journal of Cell Science.

[10]  M. Birnbaum,et al.  AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. , 2004, The Journal of clinical investigation.

[11]  D. Hardie,et al.  Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. , 2004, American journal of physiology. Endocrinology and metabolism.

[12]  Lewis C Cantley,et al.  The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Jérôme Boudeau,et al.  LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1 , 2004, The EMBO journal.

[14]  David Carling,et al.  Supplemental Data LKB 1 Is the Upstream Kinase in the AMP-Activated Protein Kinase Cascade , 2003 .

[15]  B. Kemp,et al.  Effect of exercise intensity on skeletal muscle AMPK signaling in humans. , 2003, Diabetes.

[16]  D. Hardie,et al.  Elm1p Is One of Three Upstream Kinases for the Saccharomyces cerevisiae SNF1 Complex , 2003, Current Biology.

[17]  David Carling,et al.  Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[18]  R. McCartney,et al.  Yeast Pak1 Kinase Associates with and Activates Snf1 , 2003, Molecular and Cellular Biology.

[19]  L. Bertrand,et al.  Insulin antagonizes AMP‐activated protein kinase activation by ischemia or anoxia in rat hearts, without affecting total adenine nucleotides , 2001, FEBS letters.

[20]  A. Jovanovic,et al.  Gender-specific difference in cardiac ATP-sensitive K(+) channels. , 2001, Journal of the American College of Cardiology.

[21]  D. Carling,et al.  Phosphorylation and activation of heart PFK-2 by AMPK has a role in the stimulation of glycolysis during ischaemia , 2000, Current Biology.

[22]  S. Chirala,et al.  The subcellular localization of acetyl-CoA carboxylase 2. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[23]  G. Shulman,et al.  Translocation of myocardial GLUT-4 and increased glucose uptake through activation of AMPK by AICAR. , 1999, The American journal of physiology.

[24]  A. Edelman,et al.  Components of a Calmodulin-dependent Protein Kinase Cascade , 1998, The Journal of Biological Chemistry.

[25]  C. Kahn,et al.  A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. , 1998, Molecular cell.

[26]  G. Lopaschuk,et al.  High Rates of Fatty Acid Oxidation during Reperfusion of Ischemic Hearts Are Associated with a Decrease in Malonyl-CoA Levels Due to an Increase in 5′-AMP-activated Protein Kinase Inhibition of Acetyl-CoA Carboxylase (*) , 1995, The Journal of Biological Chemistry.

[27]  M. Vincent,et al.  Inhibition by AICA Riboside of Gluconeogenesis in Isolated Rat Hepatocytes , 1991, Diabetes.

[28]  J S Janicki,et al.  Impaired diastolic function and coronary reserve in genetic hypertension. Role of interstitial fibrosis and medial thickening of intramyocardial coronary arteries. , 1991, Circulation research.

[29]  B. Viollet,et al.  Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle. , 2004, The Journal of biological chemistry.

[30]  David Carling,et al.  The AMP-activated protein kinase cascade--a unifying system for energy control. , 2004, Trends in biochemical sciences.

[31]  A. Sim,et al.  Location and function of three sites phosphorylated on rat acetyl-CoA carboxylase by the AMP-activated protein kinase. , 1990, European journal of biochemistry.