How does the immune system distinguish self from nonself?

[1]  C. Janeway,et al.  Innate Immunity: The Virtues of a Nonclonal System of Recognition , 1997, Cell.

[2]  J. Zerrahn,et al.  The MHC Reactivity of the T Cell Repertoire Prior to Positive and Negative Selection , 1997, Cell.

[3]  C. Janeway,et al.  The imprint of intrathymic self-peptides on the mature T cell receptor repertoire. , 1997, Immunity.

[4]  C. Janeway.  Approaching the asymptote? Evolution and revolution in immunology. , 1989, Cold Spring Harbor symposia on quantitative biology.

[5]  C. Janeway,et al.  Microbial induction of co-stimulatory activity for CD4 T-cell growth. , 1991, International immunology.

[6]  L. Larivière,et al.  Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4) , 1999, The Journal of experimental medicine.

[7]  S. Jameson,et al.  Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands. , 1999, Immunity.

[8]  L. Glimcher,et al.  Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex , 1996, Nature.

[9]  C. Janeway,et al.  Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[10]  C. Janeway,et al.  Expression of the Co-stimulator Molecule B7–1 in Pancreatic β-Cells Accelerates Diabetes in the NOD Mouse , 1995, Diabetes.

[11]  C. Janeway,et al.  Innate immune induction of the adaptive immune response. , 1999, Cold Spring Harbor symposia on quantitative biology.

[12]  P. Ricciardi-Castagnoli,et al.  Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. , 1998, Science.

[13]  C. Janeway,et al.  Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library , 1999, Nature Medicine.

[14]  P. Marrack,et al.  The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand , 1996, Cell.

[15]  T. Brocker.  Survival of Mature CD4 T Lymphocytes Is Dependent on Major Histocompatibility Complex Class II–expressing Dendritic Cells , 1997, The Journal of experimental medicine.

[16]  M. Bevan,et al.  Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts. , 1999, Immunity.

[17]  J. Sprent,et al.  The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery. , 1999, Immunity.

[18]  H. Ruley,et al.  H2-M Mutant Mice Are Defective in the Peptide Loading of Class II Molecules, Antigen Presentation, and T Cell Repertoire Selection , 1996, Cell.

[19]  C. Janeway,et al.  Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition. , 1999, Immunity.

[20]  F. Lemonnier,et al.  Differential requirements for survival and proliferation of CD8 naïve or memory T cells. , 1997, Science.

[21]  C. Benoist,et al.  Mice Lacking H2-M Complexes, Enigmatic Elements of the MHC Class II Peptide-Loading Pathway , 1996, Cell.

[22]  C. Janeway,et al.  A human homologue of the Drosophila Toll protein signals activation of adaptive immunity , 1997, Nature.

[23]  S. Akira,et al.  Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. , 1998, Immunity.