An improved method to estimate absolute blood volume based on dialysate dilution.

Online hemodiafiltration machines equipped with a blood volume monitor and the possibility to rapidly infuse exact amounts of ultra-pure dialysate into the extracorporeal circulation can be used to determine absolute blood volume in clinical practice. The aim of the present study was to evaluate the reproducibility of such measurements. Intra-individual reproducibility was evaluated in four measurements taken in hourly intervals within the same dialysis treatment. Ten patients were studied. Absolute blood volumes measured at the beginning and after one hour of dialysis were significantly different (80.6±14.5 and 63.9±14.3 mL/kg, p<0.001) and highly reproducible between the last three measurements (63.9±14.3, 61.4±13.8 and 60.9±13.9 mL/kg, p=n.s.). Measurement of absolute blood volume after one hour of treatment is more precise than earlier measurements and might be better suited for guidance of ultrafiltration.

[1]  A. Wójcik-Załuska,et al.  Relative blood volume changes during haemodialysis estimated from haemoconcentration markers , 2020, Scientific Reports.

[2]  D. Schneditz,et al.  Feedback control of absolute blood volume: A new technical approach in hemodialysis , 2020, Hemodialysis international. International Symposium on Home Hemodialysis.

[3]  C. Lundby,et al.  Intravascular volumes evaluated by a carbon monoxide rebreathing method in patients undergoing chronic hemodialysis , 2020, Hemodialysis international. International Symposium on Home Hemodialysis.

[4]  M. Badaoui,et al.  Utility of a blood volume monitor in the management of anemia in dialysis by computing the total hemoglobin mass , 2019, Hemodialysis international. International Symposium on Home Hemodialysis.

[5]  P. Brenchley,et al.  Transcapillary Refilling Rate and Its Determinants during Haemodialysis with Standard and High Ultrafiltration Rates , 2019, American Journal of Nephrology.

[6]  K. Budde,et al.  Adjustment of target weight based on absolute blood volume reduces the frequency of intradialytic morbid events , 2018, Hemodialysis international. International Symposium on Home Hemodialysis.

[7]  D. Schneditz,et al.  Determination of the critical absolute blood volume for intradialytic morbid events , 2016, Hemodialysis international. International Symposium on Home Hemodialysis.

[8]  D. Schneditz,et al.  A Simple and Feasible Method to Determine Absolute Blood Volume in Hemodialysis Patients in Clinical Practice , 2014, Blood Purification.

[9]  Sonika PURI,et al.  Radioisotope blood volume measurement in hemodialysis patients , 2014, Hemodialysis international. International Symposium on Home Hemodialysis.

[10]  E. Lindley.  Merits and limitations of continuous blood volume monitoring during haemodialysis. Summary of the EDTNA/ERCA Journal Club discussion: Winter 2005. , 2006, EDTNA-ERCA Journal.

[11]  R. Hahn,et al.  Kinetics of Isotonic and Hypertonic Plasma Volume Expanders , 2002, Anesthesiology.

[12]  T. Kenner,et al.  Nature and rate of vascular refilling during hemodialysis and ultrafiltration. , 1992, Kidney international.

[13]  J. Horina,et al.  A blood protein monitor for the continuous measurement of blood volume changes during hemodialysis. , 1990, Kidney international.

[14]  E. Mancini,et al.  Blood volume monitoring and control. , 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.