Microencapsulated islets as bioartificial endocrine pancreas.

Single implantation of microencapsulated islets into rats with streptozotocin-induced diabetes corrected the diabetic state for 2 to 3 weeks. The microencapsulated islets remained morphologically and functionally intact throughout long-term culture studies lasting over 15 weeks.

[1]  Theodorou Na,et al.  An assessment of diffusion chambers for use in pancreatic islet cell transplantation. , 1979 .

[2]  P. Lacy,et al.  Prolongation of islet allograft survival following in vitro culture (24 degrees C) and a single injection of ALS. , 1979, Science.

[3]  R. Gates,et al.  REVERSAL OF STREPTOZOTOCIN-INDUCED DIABETES IN RATS BY INTRAPERITONEAL IMPLANTATION OF ENCAPSULATED NEONATAL RABBIT PANCREATIC TISSUE , 1977, The Lancet.

[4]  A. Sun,et al.  The Use, in Diabetic Rats and Monkeys, of Artificial Capillary Units Containing Cultured Islets of Langerhans (Artificial Endocrine Pancreas) , 1977, Diabetes.

[5]  M J Lysaght,et al.  Artificial pancreas using living beta cells:. effects on glucose homeostasis in diabetic rats. , 1977, Science.

[6]  Y. Mullen,et al.  Complete reversal of experimental diabetes mellitus in rats by a single fetal pancreas. , 1977, Science.

[7]  W. J. Tze,et al.  Implantable artificial endocrine pancreas unit used to restore normoglycaemia in the diabetic rat , 1976, Nature.

[8]  P. Lacy,et al.  Long-term Perfusion of Isolated Rats Islets in Vitro , 1976, Diabetes.

[9]  W. Chick,et al.  Beta cell culture on synthetic capillaries: an artificial endocrine pancreas , 1975, Science.

[10]  R. Gates,et al.  Return to normal of blood-glucose, plasma-insulin, and weight gain in New Zealand obese mice after implantation of islets of Langerhans. , 1972, Lancet.

[11]  P. Lacy,et al.  Method for the Isolation of Intact Islets of Langerhans from the Rat Pancreas , 1967, Diabetes.

[12]  P. J. Randle,et al.  Immunoassay of insulin with insulin antibody preciptate. , 1963, Lancet.

[13]  W. White,et al.  Studies on pituitary adrenocorticotropin. , 1950, Science.