Nitric oxide as a secretory product of mammalian cells

Evolution has resorted to nitric oxide (NO), a tiny, reactive radical gas, to mediate both servoregulatory and cytotoxic functions. This article reviews how different forms of nitric oxide synthase help confer specificity and diversity on the effects of this remarkable signaling molecule.— Nathan, C. Nitric oxide as a secretory product of mammalian cells. FASEB J. 6: 3051‐3064; 1992.

[1]  R. Rossaint,et al.  Inhaled nitric oxide for the adult respiratory distress syndrome. , 1993, The New England journal of medicine.

[2]  O. Griffith,et al.  Mammalian nitric oxide synthases. , 1999, Advances in enzymology and related areas of molecular biology.

[3]  J. Drazen,et al.  Bronchodilator action of inhaled nitric oxide in guinea pigs. , 1992, The Journal of clinical investigation.

[4]  D. Reis,et al.  Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[5]  S. Gross,et al.  Nitric oxide is a mediator of hypoxic coronary vasodilatation. Relation to adenosine and cyclooxygenase-derived metabolites. , 1992, Circulation research.

[6]  M. Simmons,et al.  Induction of Nitric Oxide Synthase in Glial Cells , 1992, Journal of neurochemistry.

[7]  S. Malawista,et al.  Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes. , 1992, The Journal of clinical investigation.

[8]  S. Snyder,et al.  Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[9]  C. Nathan,et al.  Calmodulin is a subunit of nitric oxide synthase from macrophages , 1992, The Journal of experimental medicine.

[10]  M. Marletta,et al.  Nitric oxide synthase is a cytochrome P-450 type hemoprotein. , 1992, Biochemistry.

[11]  T. Quertermous,et al.  Cloning and expression of a cDNA encoding human endothelium-derived relating factor/nitric oxide synthase. , 1992, The Journal of biological chemistry.

[12]  P. Tempst,et al.  Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[13]  A. Nussler,et al.  Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin , 1992, The Journal of experimental medicine.

[14]  P. Klatt,et al.  Ca2+/calmodulin-dependent cytochrome c reductase activity of brain nitric oxide synthase. , 1992, The Journal of biological chemistry.

[15]  S. Snyder,et al.  Nitric oxide synthase regulatory sites. Phosphorylation by cyclic AMP-dependent protein kinase, protein kinase C, and calcium/calmodulin protein kinase; identification of flavin and calmodulin binding sites. , 1992, The Journal of biological chemistry.

[16]  A. Peitzman,et al.  Increased circulating nitrogen oxides after human tumor immunotherapy: correlation with toxic hemodynamic changes. , 1992, Journal of the National Cancer Institute.

[17]  L. Ignarro,et al.  Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. , 1992, The New England journal of medicine.

[18]  Terry D. Lee,et al.  Cloning and characterization of inducible nitric oxide synthase from mouse macrophages. , 1992, Science.

[19]  J. Cunningham,et al.  Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line. , 1992, The Journal of biological chemistry.

[20]  C. Kablitz,et al.  Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy. , 1992, The Journal of clinical investigation.

[21]  R. Hotchkiss,et al.  Inhibition of NO synthesis in septic shock , 1992, The Lancet.

[22]  F. Murad,et al.  Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides. , 1992, Science.

[23]  G. Buckberg,et al.  Role of L-arginine-nitric oxide pathway in myocardial reoxygenation injury. , 1992, The American journal of physiology.

[24]  A. M. Lefer,et al.  Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. , 1992, The Journal of pharmacology and experimental therapeutics.

[25]  L. Ignarro,et al.  Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission , 1992 .

[26]  C. Nathan,et al.  CHAPTER 9 – Macrophage-Derived Nitric Oxide: Generation and Consequences , 1992 .

[27]  Colin E. Johnson,et al.  Impact of aircraft and surface emissions of nitrogen oxides on tropospheric ozone and global warming , 1992, Nature.

[28]  J. Stamler,et al.  S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[29]  B. Hoffman,et al.  Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. , 1992, The Journal of clinical investigation.

[30]  F. Murad,et al.  Purification and characterization of a human NO synthase. , 1991, Biochemical and biophysical research communications.

[31]  H. Drexler,et al.  Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine , 1991, The Lancet.

[32]  S. Moncada,et al.  Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? , 1991, The Lancet.

[33]  P. Vallance,et al.  Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock , 1991, The Lancet.

[34]  B. Brüne,et al.  Phosphorylation of nitric oxide synthase by protein kinase A. , 1991, Biochemical and biophysical research communications.

[35]  Richard Graham Knowles,et al.  Constitutive and inducible nitric oxide synthases incorporate molecular oxygen into both nitric oxide and citrulline. , 1991, The Journal of biological chemistry.

[36]  E. Kandel,et al.  Tests of the roles of two diffusible substances in long-term potentiation: evidence for nitric oxide as a possible early retrograde messenger. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[37]  D. Madison,et al.  A requirement for the intercellular messenger nitric oxide in long-term potentiation. , 1991, Science.

[38]  J. Hevel,et al.  Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein. , 1991, The Journal of biological chemistry.

[39]  S. G. Laychock,et al.  L-arginine stimulates cyclic guanosine 3',5'-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells: evidence for L-arginine:nitric oxide synthase. , 1991, Endocrinology.

[40]  F. Murad,et al.  Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[41]  T. Cebula,et al.  DNA deaminating ability and genotoxicity of nitric oxide and its progenitors. , 1991, Science.

[42]  B. Scatton,et al.  Nitric oxide mediates neuronal death after focal cerebral ischemia in the mouse. , 1991, European journal of pharmacology.

[43]  T. Higenbottam,et al.  Inhaled nitric oxide as a cause of selective pulmonary vasodilatation in pulmonary hypertension , 1991, The Lancet.

[44]  C. P. Pike,et al.  Origin of the shuttle glow , 1991, Nature.

[45]  D. Wink,et al.  Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. , 1991, Journal of medicinal chemistry.

[46]  P. Sanders,et al.  L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. , 1991, The Journal of clinical investigation.

[47]  K. Nose,et al.  Transcriptional activation of early-response genes by hydrogen peroxide in a mouse osteoblastic cell line. , 1991, European journal of biochemistry.

[48]  C. Nathan,et al.  Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide , 1991, The Journal of experimental medicine.

[49]  C. Nathan,et al.  Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[50]  S. Snyder,et al.  Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[51]  S. Reed,et al.  Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta) , 1991, The Journal of experimental medicine.

[52]  J. Covès,et al.  Inactivation of ribonucleotide reductase by nitric oxide. , 1991, Biochemical and biophysical research communications.

[53]  Y. Ben-Neriah,et al.  Redox regulation of a protein tyrosine kinase in the endoplasmic reticulum , 1991, Cell.

[54]  E. Jaffe,et al.  Cytokine-activated endothelial cells express an isotype of nitric oxide synthase which is tetrahydrobiopterin-dependent, calmodulin-independent and inhibited by arginine analogs with a rank-order of potency characteristic of activated macrophages. , 1991, Biochemical and biophysical research communications.

[55]  P. Baeuerle,et al.  A role for oxygen radicals as second messengers. , 1991, Trends in cell biology.

[56]  P. Baeuerle,et al.  Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF‐kappa B transcription factor and HIV‐1. , 1991, The EMBO journal.

[57]  R. Zatz,et al.  Effects of acute nitric oxide inhibition on rat glomerular microcirculation. , 1991, The American journal of physiology.

[58]  M. Brezis,et al.  Role of nitric oxide in renal medullary oxygenation. Studies in isolated and intact rat kidneys. , 1991, The Journal of clinical investigation.

[59]  J. Godden,et al.  The 2.3 angstrom X-ray structure of nitrite reductase from Achromobacter cycloclastes. , 1991, Science.

[60]  J. Hevel,et al.  Tissue injury caused by deposition of immune complexes is L-arginine dependent. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[61]  S. Snyder,et al.  Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[62]  G. Böhme,et al.  Possible involvement of nitric oxide in long-term potentiation. , 1991, European journal of pharmacology.

[63]  H. Eizawa,et al.  Purification of nitric oxide synthase from rat macrophages. , 1991, The Journal of biological chemistry.

[64]  S. Snyder,et al.  Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase , 1991, Nature.

[65]  J. Drapier,et al.  Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages. , 1991, The Journal of biological chemistry.

[66]  S. Hoffman,et al.  IFN-gamma inhibits development of Plasmodium berghei exoerythrocytic stages in hepatocytes by an L-arginine-dependent effector mechanism. , 1991, Journal of immunology.

[67]  S. Moncada,et al.  Nitric oxide: physiology, pathophysiology, and pharmacology. , 1991, Pharmacological reviews.

[68]  P. Kubes,et al.  Nitric oxide: an endogenous modulator of leukocyte adhesion. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[69]  J. Wallwork,et al.  Impairment of endothelium-dependent pulmonary-artery relaxation in chronic obstructive lung disease. , 1991, The New England journal of medicine.

[70]  C. Mills Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway. , 1991, Journal of immunology.

[71]  C. Nathan,et al.  N omega-hydroxy-L-arginine is an intermediate in the biosynthesis of nitric oxide from L-arginine. , 1991, The Journal of biological chemistry.

[72]  S. Vincent,et al.  Neuronal NADPH diaphorase is a nitric oxide synthase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[73]  M. Denis Journal of Leukocyte Biology 49:380-387 (1991) Tumor Necrosis Factor and Granulocyte Macrophage- Colony Stimulating Factor Stimulate Human Macrophages to Restrict Growth of Virulent Mycobacterium avium and to Kill Avirulent M. avium: Killing Effector Mech , 2022 .

[74]  H. Kolb,et al.  Activated macrophages kill pancreatic syngeneic islet cells via arginine-dependent nitric oxide generation. , 1991, Biochemical and biophysical research communications.

[75]  H. Eizawa,et al.  Calmodulin-independent nitric oxide synthase from rat polymorphonuclear neutrophils. , 1991, The Journal of biological chemistry.

[76]  K. Tracey,et al.  Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. , 1991, The Journal of clinical investigation.

[77]  J. Garthwaite Glutamate, nitric oxide and cell-cell signalling in the nervous system , 1991, Trends in Neurosciences.

[78]  K. Shibuki,et al.  Endogenous nitric oxide release required for long-term synaptic depression in the cerebellum , 1991, Nature.

[79]  F. Murad,et al.  Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[80]  L. Rénia,et al.  L‐Arginine‐dependent destruction of intrahepatic malaria parasites in response to tumor necrosis factor and/or interleukin 6 stimulation , 1991, European journal of immunology.

[81]  C. Nathan,et al.  Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs 1 , 1991, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[82]  C. Nathan,et al.  Role of nitric oxide synthesis in macrophage antimicrobial activity. , 1991, Current opinion in immunology.

[83]  S. Snyder,et al.  Nitric oxide as a neuronal messenger. , 1991, Trends in pharmacological sciences.

[84]  J. Hibbs Synthesis of nitric oxide from L-arginine: a recently discovered pathway induced by cytokines with antitumour and antimicrobial activity. , 1991, Research in immunology.

[85]  B. Mayer,et al.  Purification of a Ca2+/calmodulin‐dependent nitric oxide synthase from porcine cerebellum , 1990, FEBS letters.

[86]  T. Nakaki,et al.  Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells. , 1990, European journal of pharmacology.

[87]  I. Green,et al.  Inhibition of insulin secretion by interleukin‐1β and tumour necrosis factor‐α via an L‐arginine‐dependent nitric oxide generating mechanism , 1990 .

[88]  S. Brain,et al.  Evidence that endogenous nitric oxide modulates oedema formation induced by substance P. , 1990, European journal of pharmacology.

[89]  N. Boughton-Smith,et al.  Role of nitric oxide in maintaining vascular integrity in endotoxin‐induced acute intestinal damage in the rat , 1990, British journal of pharmacology.

[90]  S. Moncada,et al.  Endogenous nitric oxide as a probable modulator of pulmonary circulation and hypoxic pressor response in vivo. , 1990, Acta physiologica Scandinavica.

[91]  V. Cattell,et al.  Glomeruli synthesize nitrite in experimental nephrotoxic nephritis. , 1990, Kidney international.

[92]  D. Reif,et al.  Nitric oxide mediates iron release from ferritin. , 1990, Archives of biochemistry and biophysics.

[93]  P. Marsden,et al.  Tumor necrosis factor alpha activates soluble guanylate cyclase in bovine glomerular mesangial cells via an L-arginine-dependent mechanism , 1990, The Journal of experimental medicine.

[94]  R. L. Simmons,et al.  Modulation of Nitrogen Oxide Synthesis In Vivo: NG‐Monomethyl‐L‐Arginine Inhibits Endotoxin‐Induced Nitrate/Nitrate Biosynthesis While Promoting Hepatic Damage , 1990, Journal of leukocyte biology.

[95]  E. Werner,et al.  Tetrahydrobiopterin-dependent formation of nitrite and nitrate in murine fibroblasts , 1990, The Journal of experimental medicine.

[96]  R. Busse,et al.  Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells , 1990, FEBS letters.

[97]  J. Adams,et al.  Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. , 1990, Biochemical and biophysical research communications.

[98]  S. Moncada,et al.  Glucocorticoids inhibit the induction of nitric oxide synthase in macrophages. , 1990, Biochemical and biophysical research communications.

[99]  S. Snyder,et al.  Localization of nitric oxide synthase indicating a neural role for nitric oxide , 1990, Nature.

[100]  M. Yacoub,et al.  Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries , 1990, The Lancet.

[101]  T. Billiar,et al.  Alloantigen-induced activation of rat splenocytes is regulated by the oxidative metabolism of L-arginine. , 1990, Journal of immunology.

[102]  T. Curran,et al.  Redox regulation of fos and jun DNA-binding activity in vitro. , 1990, Science.

[103]  J. Tenu,et al.  Alterations of ribonucleotide reductase activity following induction of the nitrite-generating pathway in adenocarcinoma cells. , 1990, The Journal of biological chemistry.

[104]  C. Nathan,et al.  L-citrulline production from L-arginine by macrophage nitric oxide synthase. The ureido oxygen derives from dioxygen. , 1990, The Journal of biological chemistry.

[105]  C. Thiemermann,et al.  Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo. , 1990, European journal of pharmacology.

[106]  E. Jaffe,et al.  Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. , 1990, Biochemical and biophysical research communications.

[107]  A. Quyyumi,et al.  Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. , 1990, The New England journal of medicine.

[108]  D. Harrison,et al.  Evidence for an Astrocyte‐Derived Vasorelaxing Factor with Properties Similar to Nitric Oxide , 1990, Journal of neurochemistry.

[109]  D. Harrison,et al.  Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide , 1990, Nature.

[110]  P. Belloni,et al.  Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin. , 1990, Journal of the National Cancer Institute.

[111]  J. Adams,et al.  hypotension: Implications for the involvement of nitric oxide , 2022 .

[112]  A. M. Lefer,et al.  Beneficial effects of two forms of NO administration in feline splanchnic artery occlusion shock. , 1990, The American journal of physiology.

[113]  J. Lancaster,et al.  EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[114]  B. Freeman,et al.  Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[115]  T. Lüscher,et al.  Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. , 1990, The Journal of clinical investigation.

[116]  I. Green,et al.  Inhibition of insulin secretion by interleukin-1 beta and tumour necrosis factor-alpha via an L-arginine-dependent nitric oxide generating mechanism. , 1990, FEBS letters.

[117]  L. Ignarro Biosynthesis and metabolism of endothelium-derived nitric oxide. , 1990, Annual review of pharmacology and toxicology.

[118]  S. Snyder,et al.  Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[119]  J. Perfect,et al.  Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages. , 1990, The Journal of clinical investigation.

[120]  C. Nathan,et al.  Reduced biopterin as a cofactor in the generation of nitrogen oxides by murine macrophages. , 1989, The Journal of biological chemistry.

[121]  M. Marletta,et al.  Macrophage oxidation of L-arginine to nitric oxide, nitrite, and nitrate. Tetrahydrobiopterin is required as a cofactor. , 1989, The Journal of biological chemistry.

[122]  T. Billiar,et al.  Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells , 1989, The Journal of experimental medicine.

[123]  W. Anderson,et al.  Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[124]  B. Brüne,et al.  Activation of a cytosolic ADP-ribosyltransferase by nitric oxide-generating agents. , 1989, The Journal of biological chemistry.

[125]  S Moncada,et al.  Role of endothelium-derived nitric oxide in the regulation of blood pressure. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[126]  C. Nathan,et al.  Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells , 1989, The Journal of experimental medicine.

[127]  O. Griffith,et al.  NG-methylarginine, an inhibitor of endothelium-derived nitric oxide synthesis, is a potent pressor agent in the guinea pig: does nitric oxide regulate blood pressure in vivo? , 1989, Biochemical and biophysical research communications.

[128]  C. Nathan,et al.  Activated Murine Macrophages Secrete a Metabolite of Arginine with the Bioactivity of Endothelium-derived Relaxing Factor and the Chemical Reactivity of Nitric Oxide Materials and Methods , 2022 .

[129]  S. Weiss Tissue destruction by neutrophils. , 1989, The New England journal of medicine.

[130]  J. Hibbs,et al.  Nitric oxide: a cytotoxic activated macrophage effector molecule. , 1988, Biochemical and biophysical research communications.

[131]  M. Marletta,et al.  Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate. , 1988, Biochemistry.

[132]  J. Garthwaite,et al.  Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain , 1988, Nature.

[133]  J. Drapier,et al.  Interferon‐γ and tumor necrosis factor induce the L‐arginine‐dependent cytotoxic effector mechanism in murine macrophages* , 1988 .

[134]  C. Nathan,et al.  Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. , 1988, Journal of immunology.

[135]  J. Hibbs,et al.  The L‐Arginine Dependent Effector Mechanism Is Induced in Murine Adenocarcinoma Cells by Culture Supernatant From Cytotoxic Activated Macrophages , 1988, Journal of leukocyte biology.

[136]  L. Ignarro,et al.  Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[137]  M. Marletta,et al.  Macrophage synthesis of nitrite, nitrate, and N-nitrosamines: precursors and role of the respiratory burst. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[138]  S. Tannenbaum,et al.  Nitrosation of amines by stimulated macrophages. , 1987, Carcinogenesis.

[139]  S. Moncada,et al.  Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor , 1987, Nature.

[140]  J. Hibbs,et al.  Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. , 1987, Science.

[141]  M. Marletta,et al.  Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[142]  S. Tannenbaum,et al.  Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[143]  S R Tannenbaum,et al.  Nitrate biosynthesis in man. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[144]  L. Ignarro,et al.  Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates. , 1981, The Journal of pharmacology and experimental therapeutics.

[145]  L. Ignarro,et al.  Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators. , 1981, Blood.

[146]  P. Goldman,et al.  Nitrate synthesis in the germfree and conventional rat. , 1981, Science.

[147]  R. Furchgott,et al.  The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine , 1980, Nature.

[148]  L. Ignarro,et al.  Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine. , 1979, Journal of cyclic nucleotide research.

[149]  F. Murad,et al.  Nitric oxide activates guanylate cyclase and increases guanosine 3':5'-cyclic monophosphate levels in various tissue preparations. , 1977, Proceedings of the National Academy of Sciences of the United States of America.