CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.

[1]  C. Kemp,et al.  Induction of Lung Tumors in Mice with Urethane. , 2015, Cold Spring Harbor protocols.

[2]  V. Corces,et al.  CTCF: an architectural protein bridging genome topology and function , 2014, Nature Reviews Genetics.

[3]  S. Gabriel,et al.  Discovery and saturation analysis of cancer genes across 21 tumor types , 2014, Nature.

[4]  Victor V Lobanenkov,et al.  A genome-wide map of CTCF multivalency redefines the CTCF code. , 2013, Cell reports.

[5]  Joshua M. Stuart,et al.  Integrated genomic characterization of endometrial carcinoma , 2013, Nature.

[6]  O. Elemento,et al.  Aberration in DNA Methylation in B-Cell Lymphomas Has a Complex Origin and Increases with Disease Severity , 2013, PLoS genetics.

[7]  Matthew T. Maurano,et al.  Widespread plasticity in CTCF occupancy linked to DNA methylation , 2012, Genome research.

[8]  Steven J. M. Jones,et al.  Comprehensive molecular characterization of human colon and rectal cancer , 2012, Nature.

[9]  Steven J. M. Jones,et al.  Comprehensive molecular portraits of human breast tumors , 2012, Nature.

[10]  Francine E. Garrett-Bakelman,et al.  Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia , 2012, PLoS genetics.

[11]  C. Disteche,et al.  Loss of Maternal CTCF Is Associated with Peri-Implantation Lethality of Ctcf Null Embryos , 2012, PloS one.

[12]  Ilya Shmulevich,et al.  EPEPT: A web service for enhanced P-value estimation in permutation tests , 2011, BMC Bioinformatics.

[13]  C. Passananti,et al.  ADP-ribose polymers localized on Ctcf–Parp1–Dnmt1 complex prevent methylation of Ctcf target sites , 2011, The Biochemical journal.

[14]  Olivier Elemento,et al.  An integrated ChIP-seq analysis platform with customizable workflows , 2011, BMC Bioinformatics.

[15]  G. Getz,et al.  GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers , 2011, Genome Biology.

[16]  J. Carroll,et al.  FOXA1 is a critical determinant of Estrogen Receptor function and endocrine response , 2010, Nature Genetics.

[17]  H. Hakonarson,et al.  ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.

[18]  V. Corces,et al.  CTCF: Master Weaver of the Genome , 2009, Cell.

[19]  Marcel J. T. Reinders,et al.  Fewer permutations, more accurate P-values , 2009, Bioinform..

[20]  N. Galjart,et al.  CTCF regulates cell cycle progression of αβ T cells in the thymus , 2008, The EMBO journal.

[21]  Michael Q. Zhang,et al.  Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human Genome , 2007, Cell.

[22]  I. Ellis,et al.  Chromosome 16 tumor‐suppressor genes in breast cancer , 2006, Genes, chromosomes & cancer.

[23]  Christopher J Kemp,et al.  Tumor suppressor genetics. , 2005, Carcinogenesis.

[24]  Rolf Ohlsson,et al.  The binding sites for the chromatin insulator protein CTCF map to DNA methylation-free domains genome-wide. , 2004, Genome research.

[25]  P. Neiman,et al.  Cell growth inhibition by the multifunctional multivalent zinc-finger factor CTCF. , 2001, Cancer research.

[26]  T. Yeatman,et al.  Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[27]  G. Felsenfeld,et al.  Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene , 2000, Nature.

[28]  P. Neiman,et al.  A widely expressed transcription factor with multiple DNA sequence specificity, CTCF, is localized at chromosome segment 16q22.1 within one of the smallest regions of overlap for common deletions in breast and prostate cancers , 1998, Genes, chromosomes & cancer.

[29]  G. Berx,et al.  E-cadherin is inactivated in a majority of invasive human lobular breast cancers by truncation mutations throughout its extracellular domain. , 1996, Oncogene.

[30]  G. Filippova Genetics and epigenetics of the multifunctional protein CTCF. , 2008, Current topics in developmental biology.

[31]  C. Disteche,et al.  Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. , 2005, Developmental cell.

[32]  A. Feinberg,et al.  Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity. , 2002, Cancer research.