Regulation of TOR Complex 1 by Amino Acids Through Small GTPases
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[1] Nicolas Panchaud,et al. The Vam6 GEF controls TORC1 by activating the EGO complex. , 2009, Molecular cell.
[2] A. Tee,et al. Mammalian target of rapamycin complex 1-mediated phosphorylation of eukaryotic initiation factor 4E-binding protein 1 requires multiple protein-protein interactions for substrate recognition. , 2009, Cellular signalling.
[3] Jianping Ding,et al. Molecular Basis of the Acceleration of the GDP-GTP Exchange of Human Ras Homolog Enriched in Brain by Human Translationally Controlled Tumor Protein* , 2009, The Journal of Biological Chemistry.
[4] Kathryn G. Foster,et al. Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth , 2009, Molecular and Cellular Biology.
[5] T. Sturgill,et al. Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity Is Associated with Phosphorylation of Raptor by mTOR* , 2009, Journal of Biological Chemistry.
[6] A. Nakashima,et al. Specific Activation of mTORC1 by Rheb G-protein in Vitro Involves Enhanced Recruitment of Its Substrate Protein* , 2009, Journal of Biological Chemistry.
[7] D. Sabatini,et al. An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1* , 2009, Journal of Biological Chemistry.
[8] A. Wittinghofer,et al. Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway , 2009, FEBS letters.
[9] Robbie Loewith,et al. Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2 , 2009, PLoS biology.
[10] Haiyan Wu,et al. hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells , 2008, The Biochemical journal.
[11] Hua Tang,et al. Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling* , 2008, Journal of Biological Chemistry.
[12] C. Stanley,et al. Untangling the glutamate dehydrogenase allosteric nightmare. , 2008, Trends in biochemical sciences.
[13] X. Bai,et al. The Switch I Region of Rheb Is Critical for Its Interaction with FKBP38* , 2008, Journal of Biological Chemistry.
[14] Philippe P Roux,et al. Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation , 2008, Current Biology.
[15] A. Wittinghofer,et al. Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb , 2008, FEBS letters.
[16] E. Jacinto. What controls TOR? , 2008, IUBMB life.
[17] T. P. Neufeld,et al. Regulation of TORC1 by Rag GTPases in nutrient response , 2008, Nature Cell Biology.
[18] H. A. Brown,et al. Phospholipase D1 is an effector of Rheb in the mTOR pathway , 2008, Proceedings of the National Academy of Sciences.
[19] David M. Sabatini,et al. The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1 , 2008, Science.
[20] B. Manning,et al. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. , 2008, The Biochemical journal.
[21] T. P. Neufeld,et al. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila , 2008, The Journal of cell biology.
[22] F. Natt,et al. Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. , 2008, Cell metabolism.
[23] M. Drummond,et al. Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis , 2008, Current opinion in clinical nutrition and metabolic care.
[24] C. Proud,et al. The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK. , 2008, The Biochemical journal.
[25] J. Backer. The regulation and function of Class III PI3Ks: novel roles for Vps34. , 2008, The Biochemical journal.
[26] Adiel Cohen,et al. PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis , 2007, PloS one.
[27] X. Bai,et al. Rheb Activates mTOR by Antagonizing Its Endogenous Inhibitor, FKBP38 , 2007, Science.
[28] C. Proud,et al. PRAS40 Is a Target for Mammalian Target of Rapamycin Complex 1 and Is Required for Signaling Downstream of This Complex* , 2007, Journal of Biological Chemistry.
[29] F. Tamanoi,et al. The TSC/Rheb/TOR Signaling Pathway in Fission Yeast and Mammalian Cells: Temperature Sensitive and Constitutive Active Mutants of TOR , 2007, Cell cycle.
[30] A. Nakashima,et al. The Proline-rich Akt Substrate of 40 kDa (PRAS40) Is a Physiological Substrate of Mammalian Target of Rapamycin Complex 1* , 2007, Journal of Biological Chemistry.
[31] R. Roth,et al. PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding* , 2007, Journal of Biological Chemistry.
[32] J. Avruch,et al. The Rheb Switch 2 Segment Is Critical for Signaling to Target of Rapamycin Complex 1* , 2007, Journal of Biological Chemistry.
[33] V. Mieulet,et al. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. , 2007, The Biochemical journal.
[34] S. Carr,et al. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. , 2007, Molecular cell.
[35] Mingyao Liu,et al. Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase , 2007, Nature.
[36] Timothy J. Griffin,et al. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40 , 2007, Nature Cell Biology.
[37] J. Avruch,et al. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase , 2006, Oncogene.
[38] C. Shi,et al. The Mitogen-Activated Protein Kinase Kinase Kinase Kinase GCKR Positively Regulates Canonical and Noncanonical Wnt Signaling in B Lymphocytes , 2006, Molecular and Cellular Biology.
[39] J. Lawrence,et al. Activation of Mammalian Target of Rapamycin (mTOR) by Insulin Is Associated with Stimulation of 4EBP1 Binding to Dimeric mTOR Complex 1* , 2006, Journal of Biological Chemistry.
[40] H. Stenmark,et al. Regulation of membrane traffic by phosphoinositide 3-kinases , 2006, Journal of Cell Science.
[41] J. Bos,et al. Regulation of the small GTPase Rheb by amino acids , 2006, Oncogene.
[42] S. Kimball,et al. New functions for amino acids: effects on gene transcription and translation. , 2006, The American journal of clinical nutrition.
[43] J. Urano,et al. Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast , 2005, Molecular microbiology.
[44] F. Natt,et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[45] James T. Murray,et al. hVps34 Is a Nutrient-regulated Lipid Kinase Required for Activation of p70 S6 Kinase* , 2005, Journal of Biological Chemistry.
[46] A. Hinnebusch. Translational regulation of GCN4 and the general amino acid control of yeast. , 2005, Annual review of microbiology.
[47] J. Avruch,et al. Rheb Binding to Mammalian Target of Rapamycin (mTOR) Is Regulated by Amino Acid Sufficiency* , 2005, Journal of Biological Chemistry.
[48] D. Sabatini,et al. Structure of S6 Kinase 1 Determines whether Raptor-mTOR or Rictor-mTOR Phosphorylates Its Hydrophobic Motif Site*♦ , 2005, Journal of Biological Chemistry.
[49] C. Proud,et al. The Tuberous Sclerosis Protein TSC2 Is Not Required for the Regulation of the Mammalian Target of Rapamycin by Amino Acids and Certain Cellular Stresses* , 2005, Journal of Biological Chemistry.
[50] Joseph Avruch,et al. Rheb Binds and Regulates the mTOR Kinase , 2005, Current Biology.
[51] Paul Tempst,et al. Phosphorylation and Functional Inactivation of TSC2 by Erk Implications for Tuberous Sclerosisand Cancer Pathogenesis , 2005, Cell.
[52] Steven P Gygi,et al. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. , 2004, Proceedings of the National Academy of Sciences of the United States of America.
[53] T. Anthony,et al. Preservation of Liver Protein Synthesis during Dietary Leucine Deprivation Occurs at the Expense of Skeletal Muscle Mass in Mice Deleted for eIF2 Kinase GCN2* , 2004, Journal of Biological Chemistry.
[54] M. Hengstschläger,et al. Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38 , 2003, Oncogene.
[55] M. Birnbaum,et al. Identification of a Proline-rich Akt Substrate as a 14-3-3 Binding Partner* , 2003, The Journal of Biological Chemistry.
[56] K. Nakayama,et al. Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis , 2003, Nature Cell Biology.
[57] C. MacKintosh,et al. Regulation of the 14-3-3-binding protein p39 by growth factors and nutrients in rat PC12 pheochromocytoma cells. , 2002, The Biochemical journal.
[58] J. Blenis,et al. Identification of a Conserved Motif Required for mTOR Signaling , 2002, Current Biology.
[59] C. Proud,et al. Intracellular Sensing of Amino Acids in Xenopus laevis Oocytes Stimulates p70 S6 Kinase in a Target of Rapamycin-dependent Manner* , 2002, The Journal of Biological Chemistry.
[60] Jie Chen,et al. Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling , 2001, Science.
[61] S. Kimball,et al. Regulation of amino acid–sensitive TOR signaling by leucine analogues in adipocytes , 2000, Journal of cellular biochemistry.
[62] A. Leonardi,et al. TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. , 1999, Journal of immunology.
[63] J. Avruch,et al. Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways , 1999, The Journal of Biological Chemistry.
[64] J. Avruch,et al. Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism* , 1998, The Journal of Biological Chemistry.
[65] A. Gingras,et al. 4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[66] I. Stansfield,et al. An MBoC Favorite: TOR controls translation initiation and early G1 progression in yeast , 2012, Molecular biology of the cell.
[67] J. Avruch,et al. Multiple independent inputs are required for activation of the p70 S6 kinase , 1995, Molecular and cellular biology.
[68] J. Avruch,et al. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. , 1992, Science.
[69] G. Crabtree,et al. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases , 1992, Cell.