Knee Osteoarthritis: A Primer.

The purpose of this article is to provide a synopsis of the current medical understanding of knee osteoarthritis. We describe the prevalence, causes and associated risk factors, symptoms, diagnosis and classification, and treatment options. A quiz serves to assist readers in their understanding of the presented material.

[1]  M. Buttaro,et al.  Hip Arthroscopy in Osteoarthritis: A Systematic Review of the Literature , 2016, Hip international : the journal of clinical and experimental research on hip pathology and therapy.

[2]  L. Nartey,et al.  Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis , 2017, The Lancet.

[3]  Gheorghe Luta,et al.  Prevalence of knee symptoms and radiographic and symptomatic knee osteoarthritis in African Americans and Caucasians: the Johnston County Osteoarthritis Project. , 2007, The Journal of rheumatology.

[4]  D. Felson.  Obesity and osteoarthritis of the knee. , 1992, Bulletin on the rheumatic diseases.

[5]  F. Berenbaum,et al.  Is osteoarthritis a metabolic disease? , 2013, Joint, bone, spine : revue du rhumatisme.

[6]  A. Rutjes,et al.  Intra-articular corticosteroid for knee osteoarthritis. , 2015, The Cochrane database of systematic reviews.

[7]  Greg A. Brown.  AAOS clinical practice guideline: treatment of osteoarthritis of the knee: evidence-based guideline, 2nd edition. , 2013, The Journal of the American Academy of Orthopaedic Surgeons.

[8]  M. Blagojevic,et al.  Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. , 2010, Osteoarthritis and cartilage.

[9]  S. Gabriel,et al.  Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. , 2008, Arthritis and rheumatism.

[10]  K. Kalunian,et al.  Validation of American College of Rheumatology classification criteria for knee osteoarthritis using arthroscopically defined cartilage damage scores. , 2005, Seminars in arthritis and rheumatism.

[11]  F. Berenbaum,et al.  Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!). , 2013, Osteoarthritis and cartilage.

[12]  A. Malfait.  Osteoarthritis year in review 2015: biology. , 2016, Osteoarthritis and cartilage.

[13]  C. Juhl,et al.  Arthroscopic surgery for degenerative knee: systematic review and meta-analysis of benefits and harms , 2015, BMJ : British Medical Journal.

[14]  Raju Vaishya,et al.  Non-operative management of osteoarthritis of the knee joint. , 2016, Journal of clinical orthopaedics and trauma.

[15]  Thomas D Brown,et al.  Posttraumatic Osteoarthritis: A First Estimate of Incidence, Prevalence, and Burden of Disease , 2006, Journal of orthopaedic trauma.

[16]  D. Scott,et al.  The management of knee pain in primary care: factors associated with consulting the GP and referrals to secondary care. , 2006, Rheumatology.

[17]  G. Orive,et al.  Efficacy and safety of plasma rich in growth factors intra-articular infiltrations in the treatment of knee osteoarthritis. , 2014, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[18]  K. Hagen.  Canes for knee osteoarthritis: is a randomised trial necessary? , 2011, Annals of the rheumatic diseases.

[19]  C. Helmick,et al.  Prevalence of Hip Symptoms and Radiographic and Symptomatic Hip Osteoarthritis in African Americans and Caucasians: The Johnston County Osteoarthritis Project , 2009, The Journal of Rheumatology.

[20]  Michael A Mont,et al.  Unloader Bracing for Knee Osteoarthritis: A Pilot Study of Gait and Function. , 2015, Surgical technology international.

[21]  P. Marks,et al.  The efficacy of platelet-rich plasma in the treatment of symptomatic knee osteoarthritis: a systematic review with quantitative synthesis. , 2013, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[22]  Nigel K. Arden,et al.  Epidemiology of osteoarthritis , 2014 .

[23]  N. Simunovic,et al.  Cochrane in CORR®: Viscosupplementation for the Treatment of Osteoarthritis of the Knee , 2014, Clinical orthopaedics and related research.

[24]  B. Heidari.  Knee osteoarthritis prevalence, risk factors, pathogenesis and features: Part I. , 2011, Caspian journal of internal medicine.

[25]  Ewa M. Roos,et al.  Strategies for the prevention of knee osteoarthritis , 2016, Nature Reviews Rheumatology.

[26]  A. Johnson,et al.  Scientific evidence for the use of modern unicompartmental knee arthroplasty , 2010, Expert review of medical devices.

[27]  A. Pearle,et al.  Modern Indications, Results, and Global Trends in the Use of Unicompartmental Knee Arthroplasty and High Tibial Osteotomy in the Treatment of Isolated Medial Compartment Osteoarthritis. , 2016, American journal of orthopedics.

[28]  K. Belhaj,et al.  Impact of knee osteoarthritis on the quality of life , 2016 .

[29]  S. Goldring,et al.  The role of synovitis in osteoarthritis pathogenesis. , 2012, Bone.

[30]  R. Rossi,et al.  High tibial osteotomy in varus knees: indications and limits , 2016, Joints.

[31]  P. Kasten,et al.  Surgical options for patients with osteoarthritis of the knee , 2009, Nature Reviews Rheumatology.

[32]  J. Parvizi,et al.  Obesity and total joint arthroplasty: a literature based review. , 2013, The Journal of arthroplasty.

[33]  R. Loeser,et al.  Aging-related inflammation in osteoarthritis. , 2015, Osteoarthritis and cartilage.

[34]  C. Laurencin,et al.  Animal models of osteoarthritis: classification, update, and measurement of outcomes , 2016, Journal of Orthopaedic Surgery and Research.

[35]  Roland Starr,et al.  Strength and Functional Improvement Using Pneumatic Brace with Extension Assist for End-Stage Knee Osteoarthritis: A Prospective, Randomized trial. , 2015, The Journal of arthroplasty.

[36]  J. Regnaux,et al.  High-intensity versus low-intensity physical activity or exercise in people with hip or knee osteoarthritis. , 2015, The Cochrane database of systematic reviews.

[37]  S. Olson,et al.  Osteoarthritis: From Palliation to Prevention: AOA Critical Issues. , 2014, The Journal of bone and joint surgery. American volume.

[38]  M. Jacobi,et al.  Current Surgical Treatment of Knee Osteoarthritis , 2011, Arthritis.

[39]  A. Verhagen,et al.  Braces and orthoses for treating osteoarthritis of the knee. , 2005, The Cochrane database of systematic reviews.

[40]  J. Kellgren,et al.  Radiological Assessment of Osteo-Arthrosis , 1957, Annals of the rheumatic diseases.

[41]  G. Muschler,et al.  Intra-Articular Cellular Therapy for Osteoarthritis and Focal Cartilage Defects of the Knee: A Systematic Review of the Literature and Study Quality Analysis. , 2016, The Journal of bone and joint surgery. American volume.

[42]  J. Jordan,et al.  Epidemiology of osteoarthritis. , 2010, Clinics in geriatric medicine.

[43]  A. I.,et al.  Neural Field Continuum Limits and the Structure–Function Partitioning of Cognitive–Emotional Brain Networks , 2023, Biology.

[44]  S Kirschner,et al.  EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis , 2009, Annals of the rheumatic diseases.

[45]  B. Cole,et al.  Effect of Leukocyte Concentration on the Efficacy of Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis , 2016, The American journal of sports medicine.

[46]  R. Moskowitz,et al.  Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association. , 1986, Arthritis and rheumatism.

[47]  F. Cicuttini,et al.  Tackling obesity in knee osteoarthritis , 2013, Nature Reviews Rheumatology.

[48]  V. Kraus,et al.  The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive , 2015, The Journal of Rheumatology.

[49]  Nigel Arden,et al.  Osteoarthritis: epidemiology. , 2006, Best practice & research. Clinical rheumatology.

[50]  Hikmat N. Daghestani,et al.  Inflammatory biomarkers in osteoarthritis. , 2015, Osteoarthritis and cartilage.

[51]  Der-Sheng Han,et al.  Comparative effectiveness of platelet-rich plasma injections for treating knee joint cartilage degenerative pathology: a systematic review and meta-analysis. , 2014, Archives of physical medicine and rehabilitation.

[52]  A. Grodzinsky,et al.  Osteoarthritis year in review 2015: mechanics. , 2015, Osteoarthritis and cartilage.

[53]  T. Mckeown.  Mechanics , 1970, The Mathematics of Fluid Flow Through Porous Media.

[54]  Michael A. Mont,et al.  Management of Primary Knee Osteoarthritis and Indications for Total Knee Arthroplasty for General Practitioners , 2012, The Journal of the American Osteopathic Association.

[55]  R. Starr,et al.  Gait Using Pneumatic Brace for End-Stage Knee Osteoarthritis , 2016, The Journal of Knee Surgery.

[56]  D. Chutka,et al.  A Practical Guide to Clinical Medicine , 2001 .

[57]  D. Dirschl,et al.  Hyaluronic Acid Injections for Treatment of Advanced Osteoarthritis of the Knee: Utilization and Cost in a National Population Sample. , 2016, The Journal of bone and joint surgery. American volume.

[58]  A. Zaninelli,et al.  Analysis of pharmacologic and nonpharmacologic prescription patterns of general practitioners and specialists in the AMICA study. , 2005, Seminars in arthritis and rheumatism.

[59]  J. Jauregui,et al.  The effects of various physical non-operative modalities on the pain in osteoarthritis of the knee. , 2016, The bone & joint journal.

[60]  Robin Christensen,et al.  The treatment and prevention of knee osteoarthritis: a tool for clinical decision-making , 2009, Expert opinion on pharmacotherapy.