Cannabinoid-Induced Activation of ERK and AKT in Mast Cells May Be Mediated by Intracellular NO Production

Samson and colleagues elegantly demonstrated the coexpression of CB1/CB2 receptors in a mast cell line (RBL2H3) and noted that while CB1 was functional in the suppression of serotonin release, CB2 was the predominant mediator of cannabinoid-induced AKT and ERK kinase phosphorylation ([1][1]). We