Circulating microRNAs in hematological diseases: principles, challenges, and perspectives.

The complex microRNA (miRNA) network plays an important role in the regulation of cellular processes such as development, differentiation, and apoptosis. Recently, the presence of cell-free miRNAs that circulate in body fluids was discovered. The ability of these circulating miRNAs to mirror physiological and pathophysiological conditions as well as their high stability in stored patient samples underlines the potential of these molecules to serve as biomarkers for various diseases. In this review, we describe recent findings in miRNA-mediated cell-to-cell communication and the functions of circulating miRNAs in the field of hematology. Furthermore, we discuss current approaches to design biomarker studies with circulating miRNAs. This article critically reviews the novel field of circulating miRNAs and highlights their suitability for clinical and basic research in addition to their potential as a novel class of biomarkers.

[1]  Michael Chopp,et al.  Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth. , 2013, Cancer letters.

[2]  M. Kuroda,et al.  Leukemia cell to endothelial cell communication via exosomal miRNAs , 2013, Oncogene.

[3]  Yisrael Parmet,et al.  Differences in microRNA detection levels are technology and sequence dependent. , 2013, RNA.

[4]  石原 香織.  Impact of miR-155 and miR-126 as novel biomarkers on the assessment of disease progression and prognosis in adult T-cell leukemia , 2013 .

[5]  N. Munshi,et al.  Targeting miR-21 Inhibits In Vitro and In Vivo Multiple Myeloma Cell Growth , 2013, Clinical Cancer Research.

[6]  Melissa G. Piper,et al.  Macrophage microvesicles induce macrophage differentiation and miR-223 transfer. , 2013, Blood.

[7]  C. Andersen,et al.  Circulating U2 small nuclear RNA fragments as a novel diagnostic biomarker for pancreatic and colorectal adenocarcinoma , 2013, International journal of cancer.

[8]  吉澤 成一郎.  Downregulated plasma miR-92a levels have clinical impact on multiple myeloma and related disorders , 2013 .

[9]  T. Blondal,et al.  Assessing sample and miRNA profile quality in serum and plasma or other biofluids. , 2013, Methods.

[10]  D. Farber,et al.  Embryonic Stem Cell-Derived Microvesicles Induce Gene Expression Changes in Müller Cells of the Retina , 2012, PloS one.

[11]  Aaron M. King,et al.  Identification of circulating microRNAs as diagnostic biomarkers for use in multiple myeloma , 2012, British Journal of Cancer.

[12]  K. Kodys,et al.  Circulating microRNAs in exosomes indicate hepatocyte injury and inflammation in alcoholic, drug‐induced, and inflammatory liver diseases , 2012, Hepatology.

[13]  H. Döhner,et al.  Impact of serum storage conditions on microRNA stability , 2012, Leukemia.

[14]  G. Camussi,et al.  Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells. , 2012, Kidney international.

[15]  David J. Galas,et al.  Comparing the MicroRNA Spectrum between Serum and Plasma , 2012, PloS one.

[16]  K. Horgan,et al.  Circulating microRNA profiles reflect the presence of breast tumours but not the profiles of microRNAs within the tumours , 2012, Cellular Oncology.

[17]  H. Buermans,et al.  Deep sequencing of RNA from immune cell-derived vesicles uncovers the selective incorporation of small non-coding RNA biotypes with potential regulatory functions , 2012, Nucleic acids research.

[18]  Lucy Pigati,et al.  MicroRNAs are exported from malignant cells in customized particles , 2012, Nucleic acids research.

[19]  Roberta Galli,et al.  MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response , 2012, Proceedings of the National Academy of Sciences.

[20]  Yi Li,et al.  Exosome‐Mediated Transfer of miR‐133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth , 2012, Stem cells.

[21]  V. Kim,et al.  Short structured RNAs with low GC content are selectively lost during extraction from a small number of cells. , 2012, Molecular cell.

[22]  G. Camussi,et al.  Human Liver Stem Cell-Derived Microvesicles Inhibit Hepatoma Growth in SCID Mice by Delivering Antitumor MicroRNAs , 2012, Stem cells.

[23]  W. Schmiegel,et al.  MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma , 2012, Journal of Neuro-Oncology.

[24]  Christopher J. Cheng,et al.  Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma , 2012, Proceedings of the National Academy of Sciences.

[25]  Frederick Luk,et al.  Microparticle conferred microRNA profiles - implications in the transfer and dominance of cancer traits , 2012, Molecular Cancer.

[26]  D. Maric,et al.  MicroRNA126 contributes to granulocyte colony-stimulating factor-induced hematopoietic progenitor cell mobilization by reducing the expression of vascular cell adhesion molecule 1 , 2012, Haematologica.

[27]  R. Qi,et al.  Identification of endogenous normalizers for serum MicroRNAs by microarray profiling: U6 small nuclear RNA is not a reliable normalizer , 2012, Hepatology.

[28]  M. Tewari,et al.  MicroRNA profiling: approaches and considerations , 2012, Nature Reviews Genetics.

[29]  Chad A Mirkin,et al.  Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid-gold nanoparticle conjugates. , 2012, Analytical chemistry.

[30]  Honggang Li,et al.  Cell-Free Seminal mRNA and MicroRNA Exist in Different Forms , 2012, PloS one.

[31]  H. Döhner,et al.  Targeted therapies through microRNAs: pulp or fiction? , 2012, Therapeutic advances in hematology.

[32]  R. Zhong,et al.  Circulating microRNA expression is associated with genetic subtype and survival of multiple myeloma , 2012, Medical Oncology.

[33]  Achilleas S. Frangakis,et al.  Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs , 2012, Nature Cell Biology.

[34]  Simon C Watkins,et al.  Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. , 2012, Blood.

[35]  D. M.,et al.  Identification of Endogenous Normalizers for Serum MicroRNAs by Microarray Profiling : U 6 Small Nuclear RNA Is Not a Reliable Normalizer To the , 2012 .

[36]  Jan Hellemans,et al.  miRNA expression profiling: from reference genes to global mean normalization. , 2012, Methods in molecular biology.

[37]  Jian-yong Li,et al.  Serum microRNAs are promising novel biomarkers for diffuse large B cell lymphoma , 2012, Annals of Hematology.

[38]  Ignace Vergote,et al.  Expression profiling of cancerous and normal breast tissues identifies microRNAs that are differentially expressed in serum from patients with (metastatic) breast cancer and healthy volunteers , 2012, Breast Cancer Research.

[39]  E. Kroh,et al.  Blood Cell Origin of Circulating MicroRNAs: A Cautionary Note for Cancer Biomarker Studies , 2011, Cancer Prevention Research.

[40]  F. Kuchenbauer,et al.  Circulating microRNAs as biomarkers - True Blood? , 2011, Genome Medicine.

[41]  J. Tonn,et al.  MiRNA expression patterns predict survival in glioblastoma , 2011, Radiation oncology.

[42]  Christina Backes,et al.  Toward the blood-borne miRNome of human diseases , 2011, Nature Methods.

[43]  Y. Matsumura,et al.  Exosome can prevent RNase from degrading microRNA in feces. , 2011, Journal of gastrointestinal oncology.

[44]  Nicola J. Armstrong,et al.  Haemolysis during Sample Preparation Alters microRNA Content of Plasma , 2011, PloS one.

[45]  T. Ørntoft,et al.  Evaluation of two commercial global miRNA expression profiling platforms for detection of less abundant miRNAs , 2011, BMC Genomics.

[46]  Holger Sültmann,et al.  Loss of EpCAM expression in breast cancer derived serum exosomes: role of proteolytic cleavage. , 2011, Gynecologic oncology.

[47]  G. Camussi,et al.  Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. , 2011, Cancer research.

[48]  G. Calin,et al.  Circulating microRNAs let-7a and miR-16 predict progression-free survival and overall survival in patients with myelodysplastic syndrome. , 2011, Blood.

[49]  Alicia Algeciras-Schimnich,et al.  Analysis of circulating microRNA: preanalytical and analytical challenges. , 2011, Clinical chemistry.

[50]  B. Burwinkel,et al.  Characterization of extracellular circulating microRNA , 2011, Nucleic acids research.

[51]  Fátima Sánchez-Cabo,et al.  Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells , 2011, Nature communications.

[52]  David J. Galas,et al.  MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia , 2011, Proceedings of the National Academy of Sciences.

[53]  R. Gold,et al.  Identification of microRNAs in the cerebrospinal fluid as marker for primary diffuse large B-cell lymphoma of the central nervous system. , 2011, Blood.

[54]  E. Kroh,et al.  Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma , 2011, Proceedings of the National Academy of Sciences.

[55]  Masahiko Kuroda,et al.  Clinical Impact of Down-Regulated Plasma miR-92a Levels in Non-Hodgkin's Lymphoma , 2011, PloS one.

[56]  K. Vickers,et al.  MicroRNAs are Transported in Plasma and Delivered to Recipient Cells by High-Density Lipoproteins , 2011, Nature Cell Biology.

[57]  Ciro Tetta,et al.  Exosome/microvesicle-mediated epigenetic reprogramming of cells. , 2011, American journal of cancer research.

[58]  Chengcheng Guo,et al.  Diagnostic and Prognostic Value of Circulating miR-221 for Extranodal Natural Killer/T-Cell Lymphoma , 2011, Disease markers.

[59]  M. Caligiuri,et al.  Prognostic significance of expression of a single microRNA, miR-181a, in cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[60]  Jessica A. Weber,et al.  The microRNA spectrum in 12 body fluids. , 2010, Clinical chemistry.

[61]  M. Chopp,et al.  Functional microRNA is transferred between glioma cells. , 2010, Cancer research.

[62]  A. Savonenko,et al.  Inhibition of neutral sphingomyelinase‐2 perturbs brain sphingolipid balance and spatial memory in mice , 2010, Journal of neuroscience research.

[63]  Ben Berkhout,et al.  A miRNA-tRNA mix-up: tRNA origin of proposed miRNA , 2010, RNA biology.

[64]  Luca Sterpone,et al.  Microvesicles Derived from Adult Human Bone Marrow and Tissue Specific Mesenchymal Stem Cells Shuttle Selected Pattern of miRNAs , 2010, PloS one.

[65]  Jing Li,et al.  Secreted monocytic miR-150 enhances targeted endothelial cell migration. , 2010, Molecular cell.

[66]  Jessica A. Weber,et al.  Export of microRNAs and microRNA-protective protein by mammalian cells , 2010, Nucleic acids research.

[67]  Tian Sheng Chen,et al.  Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs , 2009, Nucleic acids research.

[68]  H. Döhner,et al.  From pathogenesis to treatment of chronic lymphocytic leukaemia , 2010, Nature Reviews Cancer.

[69]  M. Hristov,et al.  Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection , 2009, Science Signaling.

[70]  Teresa Colombo,et al.  Characterization of B‐ and T‐lineage acute lymphoblastic leukemia by integrated analysis of MicroRNA and mRNA expression profiles , 2009, Genes, chromosomes & cancer.

[71]  E. Cuppen,et al.  Limitations and possibilities of small RNA digital gene expression profiling , 2009, Nature Methods.

[72]  M. Kudo,et al.  Down-Regulation of miR-92 in Human Plasma Is a Novel Marker for Acute Leukemia Patients , 2009, PloS one.

[73]  Erin K Hanson,et al.  Identification of forensically relevant body fluids using a panel of differentially expressed microRNAs. , 2009, Analytical biochemistry.

[74]  D. Farber,et al.  Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles , 2009, PloS one.

[75]  Malachi Griffith,et al.  In-depth characterization of the microRNA transcriptome in a leukemia progression model. , 2008, Genome research.

[76]  Daniel B. Martin,et al.  Circulating microRNAs as stable blood-based markers for cancer detection , 2008, Proceedings of the National Academy of Sciences.

[77]  A. Harris,et al.  Detection of elevated levels of tumour‐associated microRNAs in serum of patients with diffuse large B‐cell lymphoma , 2008, British journal of haematology.

[78]  Bob Löwenberg,et al.  MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. , 2008, Blood.

[79]  Jennifer L. Osborn,et al.  Direct multiplexed measurement of gene expression with color-coded probe pairs , 2008, Nature Biotechnology.

[80]  Todd R. Golub,et al.  MicroRNA Expression Signatures Accurately Discriminate Acute Lymphoblastic Leukemia from Acute Myeloid Leukemia. , 2007 .

[81]  Shamit Soneji,et al.  Microrna expression distinguishes between germinal center B cell‐like and activated B cell‐like subtypes of diffuse large B cell lymphoma , 2007, International journal of cancer.

[82]  H. Horvitz,et al.  MicroRNA expression profiles classify human cancers , 2005, Nature.

[83]  C. Croce,et al.  MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[84]  D. Bartel.  MicroRNAs Genomics, Biogenesis, Mechanism, and Function , 2004, Cell.

[85]  B. Reinhart,et al.  The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans , 2000, Nature.

[86]  J. Wengel,et al.  The first analogues of LNA (locked nucleic acids): phosphorothioate-LNA and 2'-thio-LNA. , 1998, Bioorganic & medicinal chemistry letters.

[87]  V. Ambros,et al.  The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 , 1993, Cell.