Permeability of the blood–brain barrier predicts conversion from optic neuritis to multiple sclerosis

See Naismith and Cross (doi:10.1093/brain/awv196) for a scientific commentary on this article.  Optic neuritis is highly associated with development of multiple sclerosis. Cramer et al. show that MRI measures of blood-brain barrier permeability improve prediction of conversion to multiple sclerosis within 2 years, compared to T2-lesion count alone. Permeability measures also correlate with CSF biomarkers of cellular trafficking and blood-brain barrier breakdown.

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