Noninvasive Treatment-Efficacy Evaluation for HIFU Therapy Based on Magneto-Acousto-Electrical Tomography

Objective: As a novel noninvasive modality of oncotherapy or stroke treatment, high-intensity focused ultrasound (HIFU) has drawn more and more attention in the past decades. Whereas, real-time temperature monitoring and treatment-efficacy evaluation are still the key issues for HIFU therapy. Methods: Based on the temperature–conductivity relation of tissues with a sharp conductivity variation of irreversible thermocoagulation at 69 °C, a noninvasive method of treatment-efficacy evaluation for HIFU ablation using the magneto-acousto-electrical tomography (MAET) technology is theoretically studied. By applying the nonlinear Khokhlov–Zabolotskaya–Kuznetsov equation and Pennes equation, a cylindrical model is established to simulate the distributions of pressure, temperature, and conductivity with the consideration of harmonic components. Results: The MAET signals are simulated to analyze the characteristics of the peak amplitude and the axial interval of the two clusters generated by the conductivity boundary of HIFU ablation. Conclusion: The axial interval can be used as the indictor to evaluate the size of HIFU ablation with the minimum axial width of one wavelength. Significance: The favorable results demonstrate the feasibility of real-time treatment-efficacy evaluation for HIFU therapy using the MAET technology and suggest potential applications in clinical practice.

[1]  Bin He,et al.  Investigation on magnetoacoustic signal generation with magnetic induction and its application to electrical conductivity reconstruction , 2007, Physics in medicine and biology.

[2]  刘国强,et al.  Vector Based Reconstruction Method in Magneto-Acousto-Electrical Tomography with Magnetic Induction , 2015 .

[3]  J. Tu,et al.  Non-invasive treatment efficacy evaluation for high-intensity focused ultrasound therapy using magnetically induced magnetoacoustic measurement , 2018 .

[4]  P. J. Westervelt.  Parametric Acoustic Array , 1963 .

[5]  Ronald A. Roy,et al.  Experimental validation of a tractable numerical model for focused ultrasound heating in flow-through tissue phantoms. , 2004, The Journal of the Acoustical Society of America.

[6]  D. C. Barber,et al.  Three-dimensional electrical impedance tomography , 1996, Nature.

[7]  Thomas Stein,et al.  Determination of the temperature-dependent electric conductivity of liver tissue ex vivo and in vivo: Importance for therapy planning for the radiofrequency ablation of liver tumours , 2010, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[8]  H. Griffiths,et al.  Applied potential tomography for non-invasive temperature mapping in hyperthermia. , 1987, Clinical physics and physiological measurement : an official journal of the Hospital Physicists' Association, Deutsche Gesellschaft fur Medizinische Physik and the European Federation of Organisations for Medical Physics.

[9]  J. Kennedy.  High-intensity focused ultrasound in the treatment of solid tumours , 2005, Nature Reviews Cancer.

[10]  Eung Je Woo,et al.  Magnetic resonance electrical impedance tomography (MREIT) for high-resolution conductivity imaging , 2008, Physiological measurement.

[11]  H. H. Penns.  Analysis of tissue and arterial blood temperatures in the resting human forearm , 1948 .

[12]  Yuan Xu,et al.  Magneto-Acousto-Electrical Tomography: A New Imaging Modality for Electrical Impedance , 2007 .

[13]  Qingyu Ma,et al.  Magnetoacoustic Tomography With Magnetic Induction: A Rigorous Theory , 2008, IEEE Transactions on Biomedical Engineering.

[14]  Vera A. Khokhlova,et al.  Effect of acoustic nonlinearity on heating of biological tissue by high-intensity focused ultrasound , 2001 .

[15]  J. Tu,et al.  Noninvasive treatment efficacy monitoring and dose control for high-intensity focused ultrasound therapy using relative electrical impedance variation* , 2017 .

[16]  L. Kunyansky,et al.  A mathematical model and inversion procedure for magneto-acousto-electric tomography , 2011, 1108.0376.

[17]  Liang Guo,et al.  Magneto-Acousto-Electrical Tomography With Magnetic Induction for Conductivity Reconstruction , 2015, IEEE Transactions on Biomedical Engineering.

[18]  J. Shah,et al.  Hall effect imaging , 1998, IEEE Transactions on Biomedical Engineering.

[19]  Bin He,et al.  Magnetoacoustic tomography with magnetic induction (MAT-MI) , 2005, Physics in medicine and biology.

[20]  Francis A. Duck,et al.  Physical properties of tissue : a comprehensive reference book , 1990 .

[21]  Vera A. Khokhlova,et al.  Numerical modeling of finite-amplitude sound beams: Shock formation in the near field of a cw plane piston source , 2001 .

[22]  Jean-Yves Chapelon,et al.  Lorentz force electrical impedance tomography , 2013, 1402.2573.

[23]  J Jossinet,et al.  Scanning Electric Conductivity Gradients with Ultrasonically-Induced Lorentz Force , 2001, Ultrasonic imaging.

[24]  Erlend H. Vefring,et al.  EFFECTS OF FOCUSING ON THE NONLINEAR INTERACTION BETWEEN TWO COLLINEAR FINITE AMPLITUDE SOUND BEAMS , 1991 .

[25]  E. Zabolotskaya,et al.  Quasi-plane waves in the nonlinear acoustics of confined beams , 1969 .

[26]  Yifei Xing,et al.  The effect of high intensity focused ultrasound treatment on metastases in a murine melanoma model. , 2008, Biochemical and biophysical research communications.

[27]  E L Madsen,et al.  Non-invasive ultrasound-based temperature imaging for monitoring radiofrequency heating—phantom results , 2007, Physics in medicine and biology.

[28]  L. Crum,et al.  Physical mechanisms of the therapeutic effect of ultrasound (a review) , 2003 .

[29]  J. Alison Noble,et al.  Model-based ultrasound temperature visualization during and following HIFU exposure. , 2010, Ultrasound in medicine & biology.

[30]  Xiaoning Jiang,et al.  Thrombolysis using multi-frequency high intensity focused ultrasound at MHz range: an in vitro study , 2015, Physics in medicine and biology.

[31]  Y. Xu,et al.  Magneto-acousto-electrical tomography: a potential method for imaging current density and electrical impedance , 2008, Physiological measurement.

[32]  Bradley J. Roth,et al.  Ultrasonically-induced Lorentz force tomography , 2009, Medical & Biological Engineering & Computing.

[33]  Guy Cloutier,et al.  Acousto-electrical speckle pattern in Lorentz force electrical impedance tomography. , 2015, Physics in medicine and biology.

[34]  Kullervo Hynynen,et al.  MR temperature mapping of focused ultrasound surgery , 1994, Magnetic resonance in medicine.

[35]  Xiaoning Jiang,et al.  Microbubble mediated dual-frequency high intensity focused ultrasound thrombolysis: An In vitro study , 2017 .

[36]  H. Wen,et al.  Volumetric Hall Effect Tomography — A Feasibility Study , 1999, Ultrasonic imaging.

[37]  J. Jossinet,et al.  Electric current generated by ultrasonically induced Lorentz force in biological media , 2006, Medical and Biological Engineering and Computing.

[38]  Keith Paulsen,et al.  Using multiple-electrode impedance measurements to monitor cryosurgery. , 2002, Medical physics.

[39]  F. Jolesz,et al.  Current status and future potential of MRI‐guided focused ultrasound surgery , 2008, Journal of magnetic resonance imaging : JMRI.