Towards intelligent bioreactor systems: triggering the release and mixing of compounds based on DNA-functionalized hybrid hydrogel.

We have designed and synthesized an intelligent mesoporous silica nanoparticle-DNA hydrogel bioreactor system that can be controlled by external stimuli. The system allowed the simultaneous incorporation of multiple components, and the separation between the components can be destroyed by a structural change of the DNA to initiate a reaction.

[1]  R. Martínez‐Máñez,et al.  Controlled delivery using oligonucleotide-capped mesoporous silica nanoparticles. , 2010, Angewandte Chemie.

[2]  Chulhee Kim,et al.  Photoresponsive cyclodextrin-covered nanocontainers and their sol-gel transition induced by molecular recognition. , 2009, Angewandte Chemie.

[3]  Chunhai Fan,et al.  Reconfigurable three-dimensional DNA nanostructures for the construction of intracellular logic sensors. , 2012, Angewandte Chemie.

[4]  Juewen Liu.  Oligonucleotide-functionalized hydrogels as stimuli responsive materials and biosensors , 2011 .

[5]  Maïté Marguet,et al.  Cascade reactions in multicompartmentalized polymersomes. , 2014, Angewandte Chemie.

[6]  Hao Yan,et al.  A DNA tweezer-actuated enzyme nanoreactor , 2013, Nature Communications.

[7]  F. Simmel,et al.  Controlled trapping and release of quantum dots in a DNA-switchable hydrogel. , 2007, Small.

[8]  Chulhee Kim,et al.  Glutathione‐Induced Intracellular Release of Guests from Mesoporous Silica Nanocontainers with Cyclodextrin Gatekeepers , 2010, Advanced materials.

[9]  Zhen Gu,et al.  Tailoring nanocarriers for intracellular protein delivery. , 2011, Chemical Society reviews.

[10]  Zhi Zhu,et al.  Target-responsive "sweet" hydrogel with glucometer readout for portable and quantitative detection of non-glucose targets. , 2013, Journal of the American Chemical Society.

[11]  Gleb B. Sukhorukov,et al.  Remote Control of Bioreactions in Multicompartment Capsules , 2007 .

[12]  Ying-Wei Yang,et al.  Switchable host-guest systems on surfaces. , 2014, Accounts of chemical research.

[13]  Seong Huh,et al.  Organic Functionalization and Morphology Control of Mesoporous Silicas via a Co-Condensation Synthesis Method , 2003 .

[14]  Wendelin Jan Stark,et al.  Crosslinking metal nanoparticles into the polymer backbone of hydrogels enables preparation of soft, magnetic field-driven actuators with muscle-like flexibility. , 2009, Small.

[15]  Horst Vogel,et al.  An integrated self-assembled nanofluidic system for controlled biological chemistries. , 2008, Angewandte Chemie.

[16]  M. Konrad,et al.  Enzyme reaction in the pores of CaCO3 particles upon ultrasound disruption of attached substrate-filled liposomes. , 2010, Angewandte Chemie.

[17]  Brendan D. Smith,et al.  Regenerable DNA-functionalized hydrogels for ultrasensitive, instrument-free mercury(II) detection and removal in water. , 2010, Journal of the American Chemical Society.

[18]  I. Willner,et al.  Biocatalytic release of an anticancer drug from nucleic-acids-capped mesoporous SiO2 Using DNA or molecular biomarkers as triggering stimuli. , 2013, ACS nano.

[19]  Jun Peng,et al.  Photothermally Sensitive Poly(N‐isopropylacrylamide)/Graphene Oxide Nanocomposite Hydrogels as Remote Light‐Controlled Liquid Microvalves , 2012 .

[20]  David Díaz Díaz,et al.  Stimuli-responsive gels as reaction vessels and reusable catalysts. , 2011, Chemical Society reviews.

[21]  Dongsheng Liu,et al.  A pH-triggered, fast-responding DNA hydrogel. , 2009, Angewandte Chemie.

[22]  I. Hamachi,et al.  MCM-enzyme-supramolecular hydrogel hybrid as a fluorescence sensing material for polyanions of biological significance. , 2009, Journal of the American Chemical Society.

[23]  Minghui Liu,et al.  Spatially-interactive biomolecular networks organized by nucleic acid nanostructures. , 2012, Accounts of chemical research.

[24]  R. Kasi,et al.  Hierarchically structured free-standing hydrogels with liquid crystalline domains and magnetic nanoparticles as dual physical cross-linkers. , 2012, Journal of the American Chemical Society.

[25]  N. Sugimoto,et al.  Structural Polymorphism of Telomeric DNA Regulated by pH and Divalent Cation , 2003, Nucleosides, nucleotides & nucleic acids.

[26]  Yajun Wang,et al.  Triggered enzymatic degradation of DNA within selectively permeable polymer capsule microreactors. , 2009, Angewandte Chemie.

[27]  W. Tan,et al.  Engineering target-responsive hydrogels based on aptamer-target interactions. , 2008, Journal of the American Chemical Society.

[28]  S. Basu,et al.  Coexistence of an ILPR i-motif and a partially folded structure with comparable mechanical stability revealed at the single-molecule level. , 2010, Journal of the American Chemical Society.

[29]  Félix Sancenón,et al.  Selective, highly sensitive, and rapid detection of genomic DNA by using gated materials: Mycoplasma detection. , 2013, Angewandte Chemie.

[30]  Vincent M Rotello,et al.  Intracellular delivery of a membrane-impermeable enzyme in active form using functionalized gold nanoparticles. , 2010, Journal of the American Chemical Society.

[31]  Aiqin Wang,et al.  Ag nanoparticle-entrapped hydrogel as promising material for catalytic reduction of organic dyes , 2012 .