Calcaneal Quantitative Ultrasound as a Determinant of Bone Health Status: What Properties of Bone Does It Reflect?

Quantitative ultrasound (QUS) has emerged as a convenient and popular screening tool for osteoporosis. This review aimed to provide basic information on the principle of QUS measurement and discuss the properties of bone reflected by QUS indices. QUS employed high frequency sound waves generated by the device to determine bone health status in humans. In vitro studies showed that QUS indices were significantly associated with bone mineral density (BMD), bone microarchitecture and mechanical parameters. In humans, QUS indices were found to be associated with BMD as well. In addition, QUS could discriminate subjects with and without fracture history and predict risk for future fracture. In conclusion, QUS is able to reflect bone quality and should be used in the screening of osteoporosis, especially in developing countries where dual-X-ray absorptiometry devices are less accessible to the general population.

[1]  X. Marchandise,et al.  Does Quantitative Ultrasound of Bone Reflect More Bone Mineral Density Than Bone Microarchitecture? , 2003, Calcified Tissue International.

[2]  A. Çetin,et al.  The role of quantitative ultrasound in predicting osteoporosis defined by dual-energy X-ray absorptiometry in pre- and postmenopausal women , 2008, Climacteric : the journal of the International Menopause Society.

[3]  A. Díez-Pérez,et al.  Discriminative Capacity of Calcaneal Quantitative Ultrasound and of Osteoporosis and Fracture Risk Factors in Postmenopausal Women with Osteoporotic Fractures , 2004, Calcified Tissue International.

[4]  G. Baroncelli,et al.  Quantitative Ultrasound Methods to Assess Bone Mineral Status in Children: Technical Characteristics, Performance, and Clinical Application , 2008, Pediatric Research.

[5]  S. Majumdar,et al.  Ultrasound Velocity of Trabecular Cubes Reflects Mainly Bone Density and Elasticity , 2014, Calcified Tissue International.

[6]  Robert Luben,et al.  Prediction of total and hip fracture risk in men and women by quantitative ultrasound of the calcaneus: EPIC-Norfolk prospective population study , 2004, The Lancet.

[7]  D. C. Bauer,et al.  Quantitative ultrasound predicts hip and non-spine fracture in men: the MrOS study , 2007, Osteoporosis International.

[8]  J. Davis,et al.  Effect of thiazide on rates of bone mineral loss: a longitudinal study. , 1990, BMJ.

[9]  E. Siris,et al.  Importance of precision in bone density measurements. , 2001, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[10]  I. Bosaeus,et al.  High correlation between quantitative ultrasound and DXA during 7 years of follow-up. , 2010, European journal of radiology.

[11]  G. Blake,et al.  Can the WHO Criteria for Diagnosing Osteoporosis be Applied to Calcaneal Quantitative Ultrasound? , 2000, Osteoporosis International.

[12]  J. Eisman,et al.  Absolute Fracture-Risk Prediction by a Combination of Calcaneal Quantitative Ultrasound and Bone Mineral Density , 2011, Calcified Tissue International.

[13]  M. Fini,et al.  Influence of density, elasticity, and structure on ultrasound transmission through trabecular bone cylinders , 2008, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[14]  M. Bouxsein,et al.  Quantitative Ultrasound of the Calcaneus Reflects the Mechanical Properties of Calcaneal Trabecular Bone , 1997, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[15]  Françoise Peyrin,et al.  Variation of Ultrasonic Parameters With Microstructure and Material Properties of Trabecular Bone: A 3D Model Simulation , 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[16]  A. Moayyeri,et al.  Quantitative ultrasound of the heel and fracture risk assessment: an updated meta-analysis , 2011, Osteoporosis International.

[17]  S. Yamamoto,et al.  Osteoporosis in urban post-menopausal women of the Philippines: prevalence and risk factors , 2008, Archives of Osteoporosis.

[18]  J Töyräs,et al.  Bone properties as estimated by mineral density, ultrasound attenuation, and velocity. , 1999, Bone.

[19]  R. Handa,et al.  Osteoporosis in developing countries. , 2008, Best practice & research. Clinical rheumatology.

[20]  H. Trębacz,et al.  Ultrasound Velocity and Attenuation in Cancellous Bone Samples from Lumbar Vertebra and Calcaneus , 1999, Osteoporosis International.

[21]  F Peyrin,et al.  Relationships of trabecular bone structure with quantitative ultrasound parameters: in vitro study on human proximal femur using transmission and backscatter measurements. , 2008, Bone.

[22]  V. Ferencz,et al.  Calcaneous quantitative ultrasound measurements predicts vertebral fractures in idiopathic male osteoporosis. , 2007, Joint, bone, spine : revue du rhumatisme.

[23]  Pascal Laugier,et al.  An overview of bone sonometry , 2004 .

[24]  T. Sone,et al.  Heel bone ultrasound predicts non-spine fracture in Japanese men and women , 2005, Osteoporosis International.

[25]  A. Díez-Pérez,et al.  Relationship Between Bone Quantitative Ultrasound and Fractures: A Meta‐Analysis , 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[26]  F Peyrin,et al.  Ultrasonic characterization of human cancellous bone using transmission and backscatter measurements: relationships to density and microstructure. , 2002, Bone.

[27]  M. Zanovec,et al.  Quantitative ultrasound normative reference data for community-dwelling white and black females in the United States. , 2011, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[28]  M. Koršić,et al.  Calcaneus ultrasound in males: Normative data in the Croatian population (ECUM study) , 2006, Journal of endocrinological investigation.

[29]  M. Dreher,et al.  Relationships of quantitative ultrasound parameters with cancellous bone microstructure in human calcaneus in vitro. , 2012, The Journal of the Acoustical Society of America.

[30]  J. Woo,et al.  Predictive values of calcaneal quantitative ultrasound and dual energy X ray absorptiometry for non-vertebral fracture in older men: results from the MrOS study (Hong Kong) , 2012, Osteoporosis International.

[31]  J Töyräs,et al.  Bone mineral density, ultrasound velocity, and broadband attenuation predict mechanical properties of trabecular bone differently. , 2002, Bone.

[32]  M. Jergas,et al.  Accurate assessment of precision errors: How to measure the reproducibility of bone densitometry techniques , 2005, Osteoporosis International.

[33]  S. Giannini,et al.  Quantitative ultrasound calcaneous measurements: normative data for the Italian population. the ESOPO study. , 2007, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[34]  Sihoon Lee,et al.  Modifications of T-Scores by Quantitative Ultrasonography for the Diagnosis of Osteoporosis in Koreans , 2009, Journal of Korean medical science.

[35]  S. Giannini,et al.  Association of quantitative heel ultrasound with history of osteoporotic fractures in elderly men: The ESOPO study , 2005, Osteoporosis International.

[36]  K. Chin,et al.  Discrepancy between the quantitative ultrasound value of Malaysian men and the manufacturer's reference and the impact on classification of bone health status. , 2013, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[37]  G. Lyritis,et al.  Quantitative ultrasound of the calcaneus in greek women: normative data are different from the manufacturer's normal range. , 2009, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[38]  K. Knapp.  Quantitative ultrasound and bone health. , 2009, Salud publica de Mexico.

[39]  S. Rossi,et al.  Quantitative ultrasound and dual-energy X-ray absorptiometry in the prediction of fragility fracture in men , 2005, Osteoporosis International.

[40]  P. Sambrook,et al.  Quantitative ultrasound measurements of bone: measurement error, discordance, and their effects on longitudinal studies , 2004, Osteoporosis International.

[41]  Shaomei Han,et al.  Reference data for quantitative ultrasound values of calcaneus in 2927 healthy Chinese men , 2008, Journal of Bone and Mineral Metabolism.

[42]  A. El Maghraoui,et al.  Performance of calcaneus quantitative ultrasound and dual-energy X-ray absorptiometry in the discrimination of prevalent asymptomatic osteoporotic fractures in postmenopausal women , 2009, Rheumatology International.

[43]  Anne-Marie Schott,et al.  Quantitative ultrasound in the management of osteoporosis: the 2007 ISCD Official Positions. , 2008, Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry.

[44]  G. Blake,et al.  Contact Quantitative Ultrasound: An Evaluation of Precision, Fracture Discrimination, Age-Related Bone Loss and Applicability of the WHO Criteria , 1999, Osteoporosis International.

[45]  J. Damilakis,et al.  Hip fracture discrimination by the Achilles Insight QUS imaging device. , 2007, European journal of radiology.

[46]  G. Guglielmi,et al.  Quantitative ultrasond in the assessment of osteoporosis. , 2009, European journal of radiology.