Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation.

[1]  J. Lacal,et al.  Rho GTPases: potential candidates for anticancer therapy. , 2004, Cancer letters.

[2]  D. Radisky,et al.  Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells , 2004, The Journal of cell biology.

[3]  S. Howng,et al.  Rac1 gene mutations in human brain tumours. , 2004, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[4]  Y. Wong,et al.  Constitutively Active Gα16 Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism* , 2003, Journal of Biological Chemistry.

[5]  Nastaran Zahir,et al.  Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors , 2003, The Journal of cell biology.

[6]  Valentina Gelfanova,et al.  Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß42 by Inhibiting Rho , 2003, Science.

[7]  M. Kitagawa,et al.  Evidence that reactive oxygen species do not mediate NF‐κB activation , 2003 .

[8]  M. Pucéat,et al.  A dual role of the GTPase Rac in cardiac differentiation of stem cells. , 2003, Molecular biology of the cell.

[9]  J. Lacal,et al.  ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. , 2003, Molecular biology of the cell.

[10]  C. Pothoulakis,et al.  Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways. , 2003, American journal of physiology. Cell physiology.

[11]  F. Watt,et al.  Contribution of stem cells and differentiated cells to epidermal tumours , 2003, Nature Reviews Cancer.

[12]  K. Wennerberg,et al.  Serine Phosphorylation Negatively Regulates RhoA in Vivo* , 2003, Journal of Biological Chemistry.

[13]  R. Treisman,et al.  Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL , 2003, Cell.

[14]  N. Lee,et al.  Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes , 2003, Oncogene.

[15]  G. Favre,et al.  Cloning of the human RHOB gene promoter: characterization of a VNTR sequence that affects transcriptional activity. , 2003, Genomics.

[16]  J. Galmiche,et al.  Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis. , 2003, Gastroenterology.

[17]  J. Yuan,et al.  Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution. , 2003, American journal of physiology. Cell physiology.

[18]  Michael Karin,et al.  NF-κB in cancer: a marked target , 2003 .

[19]  A. Kajdacsy-Balla,et al.  Requirement of RhoA activity for increased nuclear factor kappaB activity and PC-3 human prostate cancer cell invasion. , 2003, Cancer research.

[20]  R. Weinberg,et al.  Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. , 2003, Cancer cell.

[21]  J. Lacal,et al.  Rho GTPases in human carcinogenesis: a tale of excess , 2003, Revista de Oncología.

[22]  M. Buendia,et al.  Identification of the LIM Protein FHL2 as a Coactivator of β-Catenin* , 2003, The Journal of Biological Chemistry.

[23]  Jennifer Y. Zhang,et al.  NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia , 2003, Nature.

[24]  J. J. Gibson,et al.  Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[25]  S. Meloche,et al.  Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors , 2003, Molecular and Cellular Biology.

[26]  L. Hodgson,et al.  Melanoma cell migration to type IV collagen requires activation of NF-κB , 2003, Oncogene.

[27]  Mina J Bissell,et al.  The organizing principle: microenvironmental influences in the normal and malignant breast. , 2002, Differentiation; research in biological diversity.

[28]  M. Rao,et al.  Microarray analysis of selected genes in neural stem and progenitor cells , 2002, Journal of neurochemistry.

[29]  Yukio Nakamura,et al.  Small guanosine triphospatase RhoA and Rho-associated kinase as regulators of trophoblast migration. , 2002, The Journal of clinical endocrinology and metabolism.

[30]  R. Treisman,et al.  The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization. , 2002, Molecular biology of the cell.

[31]  K. Jakobs,et al.  Adhesiveness of human uterine epithelial RL95-2 cells to trophoblast: rho protein regulation. , 2002, Molecular human reproduction.

[32]  Tony Pawson,et al.  β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB , 2002, Cell.

[33]  Ruedi Aebersold,et al.  Quantitative proteomic analysis of Myc oncoprotein function , 2002, The EMBO journal.

[34]  B. Kaina,et al.  Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters , 2002, British Journal of Cancer.

[35]  A. Balmain,et al.  High Activity of Serum Response Factor in the Mesenchymal Transition of Epithelial Tumor Cells Is Regulated by RhoA Signaling* , 2002, The Journal of Biological Chemistry.

[36]  Yi Zheng,et al.  RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion. , 2002, Gastroenterology.

[37]  John G. Collard,et al.  Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours , 2002, Nature.

[38]  E. Sahai,et al.  ROCK and Dia have opposing effects on adherens junctions downstream of Rho , 2002, Nature Cell Biology.

[39]  R. Treisman,et al.  LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics , 2002, The Journal of cell biology.

[40]  P. Sánchez,et al.  Gli and hedgehog in cancer: tumours, embryos and stem cells , 2002, Nature Reviews Cancer.

[41]  M. Jo,et al.  Cooperativity between the Ras-ERK and Rho-Rho Kinase Pathways in Urokinase-type Plasminogen Activator-stimulated Cell Migration* , 2002, The Journal of Biological Chemistry.

[42]  Michael Karin,et al.  NF-κB in cancer: from innocent bystander to major culprit , 2002, Nature Reviews Cancer.

[43]  L. Van Aelst,et al.  The role of Rho GTPases in disease development. , 2002, Gene.

[44]  R. Mattingly,et al.  High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis , 2002, The Journal of cell biology.

[45]  A. Nordheim,et al.  Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells , 2002, The Journal of cell biology.

[46]  A. Bosserhoff,et al.  The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus , 2002, The EMBO journal.

[47]  H. Barth,et al.  Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression , 2002 .

[48]  J. Sturge,et al.  N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator. , 2002, Journal of cell science.

[49]  E. Sahai,et al.  RHO–GTPases and cancer , 2002, Nature Reviews Cancer.

[50]  D. Gingras,et al.  Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes. , 2002, The Biochemical journal.

[51]  B. Tran,et al.  Endothelin-1 stimulates human colonic myofibroblast contraction and migration , 2002, Gut.

[52]  D. Montell,et al.  Paracrine Signaling through the JAK/STAT Pathway Activates Invasive Behavior of Ovarian Epithelial Cells in Drosophila , 2001, Cell.

[53]  K. Nagata,et al.  Coronary smooth muscle differentiation from proepicardial cells requires rhoA-mediated actin reorganization and p160 rho-kinase activity. , 2001, Developmental biology.

[54]  A. Ridley,et al.  Rho family proteins: coordinating cell responses. , 2001, Trends in cell biology.

[55]  H. Clevers,et al.  Tumor environment: a potent driving force in colorectal cancer? , 2001, Trends in molecular medicine.

[56]  E. Rozengurt,et al.  Cytotoxic Necrotizing Factor fromEscherichia coli Induces RhoA-Dependent Expression of the Cyclooxygenase-2 Gene , 2001, Infection and Immunity.

[57]  I. Weissman,et al.  Stem cells, cancer, and cancer stem cells , 2001, Nature.

[58]  H. Clevers,et al.  APC, Signal transduction and genetic instability in colorectal cancer , 2001, Nature Reviews Cancer.

[59]  R. Perona,et al.  Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation. , 2001, Molecular biology of the cell.

[60]  R. Harvey,et al.  Differential Binding of an SRF/NK-2/MEF2 Transcription Factor Complex in Normal Versus Neoplastic Smooth Muscle Tissues* , 2001, The Journal of Biological Chemistry.

[61]  J. Settleman Rac 'n Rho: the music that shapes a developing embryo. , 2001, Developmental cell.

[62]  F. Watt Stem cell fate and patterning in mammalian epidermis. , 2001, Current opinion in genetics & development.

[63]  J. Soria,et al.  Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. , 2001, Carcinogenesis.

[64]  D. Bar-Sagi,et al.  Rac1 mediates STAT3 activation by autocrine IL-6 , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[65]  L. Dekker,et al.  Sequential Activation of Rac-1, SEK-1/MKK-4, and Protein Kinase Cδ Is Required for Interleukin-6-induced STAT3 Ser-727 Phosphorylation and Transactivation* , 2001, The Journal of Biological Chemistry.

[66]  Weiqun Li,et al.  Differential Requirement for Rho Family GTPases in an Oncogenic Insulin-like Growth Factor-I Receptor-induced Cell Transformation* , 2001, The Journal of Biological Chemistry.

[67]  R. Treisman,et al.  Differential Usage of Signal Transduction Pathways Defines Two Types of Serum Response Factor Target Gene* , 2001, The Journal of Biological Chemistry.

[68]  Maria Julia Marinissen,et al.  Regulation of c-myc expression by PDGF through Rho GTPases , 2001, Nature Cell Biology.

[69]  J. Taipale,et al.  The Hedgehog and Wnt signalling pathways in cancer , 2001, Nature.

[70]  David A. Williams,et al.  Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[71]  J. Lacal,et al.  Rho signals to cell growth and apoptosis. , 2001, Cancer letters.

[72]  A. Hall,et al.  Rac Mediates Cytoskeletal Rearrangements and Increased Cell Motility Induced by Urokinase-Type Plasminogen Activator Receptor Binding to Vitronectin , 2001, The Journal of cell biology.

[73]  J. Gutkind,et al.  Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway , 2001 .

[74]  L. Van Aelst,et al.  Rho GTPases: signaling, migration, and invasion. , 2000, Experimental cell research.

[75]  S. Scherer,et al.  Small GTPase Rac1: structure, localization, and expression of the human gene. , 2000, Biochemical and biophysical research communications.

[76]  D. Bar-Sagi,et al.  Ras and Rho GTPases A Family Reunion , 2000, Cell.

[77]  H. Vikis,et al.  Regulation of STAT3 by direct binding to the Rac1 GTPase. , 2000, Science.

[78]  L. Slice,et al.  Differential regulation of COX-2 transcription by Ras- and Rho-family of GTPases. , 2000, Biochemical and biophysical research communications.

[79]  E. Lengyel,et al.  Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b , 2000, Oncogene.

[80]  F. Alt,et al.  Cdc42 is required for PIP2-induced actin polymerization and early development but not for cell viability , 2000, Current Biology.

[81]  P. Jones,et al.  Regulation of urokinase receptor transcription by Ras- and Rho-family GTPases. , 2000, Biochemical and biophysical research communications.

[82]  C. Preudhomme,et al.  Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma , 2000, Oncogene.

[83]  P. Jordan,et al.  Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors , 1999, Oncogene.

[84]  J. Turkson,et al.  Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein , 1999, Molecular and Cellular Biology.

[85]  C. Der,et al.  Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation , 1999, Molecular and Cellular Biology.

[86]  N. Sato,et al.  Effect of mechanical strain on gastric cellular migration and proliferation during mucosal healing: role of Rho dependent and Rac dependent cytoskeletal reorganisation , 1999, Gut.

[87]  E. Rozengurt,et al.  Gα13 Stimulates Rho-dependent Activation of the Cyclooxygenase-2 Promoter* , 1999, The Journal of Biological Chemistry.

[88]  C. Der,et al.  Integration of Rac-dependent Regulation of Cyclin D1 Transcription through a Nuclear Factor-κB-dependent Pathway* , 1999, The Journal of Biological Chemistry.

[89]  R. Scott,et al.  Transformation blocks differentiation-induced inhibition of serum response factor interactions with serum response elements. , 1999, Cancer research.

[90]  Richard Treisman,et al.  Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics , 1999, Cell.

[91]  B. Kaina,et al.  Rho GTPases are over‐expressed in human tumors , 1999, International journal of cancer.

[92]  R. Perona,et al.  Activation of Serum Response Factor by RhoA Is Mediated by the Nuclear Factor-κB and C/EBP Transcription Factors* , 1999, The Journal of Biological Chemistry.

[93]  L. Clayton,et al.  A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeres. , 1999, Developmental biology.

[94]  Kenji Nakamura,et al.  Rac1 is required for the formation of three germ layers during gastrulation , 1998, Oncogene.

[95]  R. Perona,et al.  Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases* , 1998, The Journal of Biological Chemistry.

[96]  L. Machesky,et al.  Cytokinesis: IQGAPs find a function , 1998, Current Biology.

[97]  L. Van Aelst,et al.  Rho GTPases and signaling networks. , 1997, Genes & development.

[98]  P. Fort,et al.  Structure of the human ARHG locus encoding the Rho/Rac-like RhoG GTPase. , 1997, Genomics.

[99]  E. Chono,et al.  Expression of rac1 protein in the crypt-villus axis of rat small intestine: in reference to insulin action. , 1997, Biochemical and biophysical research communications.

[100]  R. Bravo,et al.  Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. , 1997, Genes & development.

[101]  V. Ferrans,et al.  rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation , 1996, Molecular and cellular biology.

[102]  D. Montell,et al.  Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis , 1996, The Journal of cell biology.

[103]  H. Rui,et al.  STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA. , 2003, Molecular biology of the cell.

[104]  Robert A. Weinberg,et al.  Metastasis genes: A progression puzzle , 2002, Nature.

[105]  J. Lacal,et al.  Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors. , 2001, Progress in nucleic acid research and molecular biology.