Rho GTPases in human cancer: an unresolved link to upstream and downstream transcriptional regulation.
暂无分享,去创建一个
[1] J. Lacal,et al. Rho GTPases: potential candidates for anticancer therapy. , 2004, Cancer letters.
[2] D. Radisky,et al. Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells , 2004, The Journal of cell biology.
[3] S. Howng,et al. Rac1 gene mutations in human brain tumours. , 2004, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.
[4] Y. Wong,et al. Constitutively Active Gα16 Stimulates STAT3 via a c-Src/JAK- and ERK-dependent Mechanism* , 2003, Journal of Biological Chemistry.
[5] Nastaran Zahir,et al. Autocrine laminin-5 ligates α6β4 integrin and activates RAC and NFκB to mediate anchorage-independent survival of mammary tumors , 2003, The Journal of cell biology.
[6] Valentina Gelfanova,et al. Nonsteroidal Anti-Inflammatory Drugs Can Lower Amyloidogenic Aß42 by Inhibiting Rho , 2003, Science.
[7] M. Kitagawa,et al. Evidence that reactive oxygen species do not mediate NF‐κB activation , 2003 .
[8] M. Pucéat,et al. A dual role of the GTPase Rac in cardiac differentiation of stem cells. , 2003, Molecular biology of the cell.
[9] J. Lacal,et al. ROCK and nuclear factor-kappaB-dependent activation of cyclooxygenase-2 by Rho GTPases: effects on tumor growth and therapeutic consequences. , 2003, Molecular biology of the cell.
[10] C. Pothoulakis,et al. Neurotensin stimulates IL-8 expression in human colonic epithelial cells through Rho GTPase-mediated NF-kappa B pathways. , 2003, American journal of physiology. Cell physiology.
[11] F. Watt,et al. Contribution of stem cells and differentiated cells to epidermal tumours , 2003, Nature Reviews Cancer.
[12] K. Wennerberg,et al. Serine Phosphorylation Negatively Regulates RhoA in Vivo* , 2003, Journal of Biological Chemistry.
[13] R. Treisman,et al. Actin Dynamics Control SRF Activity by Regulation of Its Coactivator MAL , 2003, Cell.
[14] N. Lee,et al. Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes , 2003, Oncogene.
[15] G. Favre,et al. Cloning of the human RHOB gene promoter: characterization of a VNTR sequence that affects transcriptional activity. , 2003, Genomics.
[16] J. Galmiche,et al. Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis. , 2003, Gastroenterology.
[17] J. Yuan,et al. Polyamines regulate Rho-kinase and myosin phosphorylation during intestinal epithelial restitution. , 2003, American journal of physiology. Cell physiology.
[18] Michael Karin,et al. NF-κB in cancer: a marked target , 2003 .
[19] A. Kajdacsy-Balla,et al. Requirement of RhoA activity for increased nuclear factor kappaB activity and PC-3 human prostate cancer cell invasion. , 2003, Cancer research.
[20] R. Weinberg,et al. Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. , 2003, Cancer cell.
[21] J. Lacal,et al. Rho GTPases in human carcinogenesis: a tale of excess , 2003, Revista de Oncología.
[22] M. Buendia,et al. Identification of the LIM Protein FHL2 as a Coactivator of β-Catenin* , 2003, The Journal of Biological Chemistry.
[23] Jennifer Y. Zhang,et al. NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia , 2003, Nature.
[24] J. J. Gibson,et al. Rho kinase and matrix metalloproteinase inhibitors cooperate to inhibit angiogenesis and growth of human prostate cancer xenotransplants , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[25] S. Meloche,et al. Rho Family GTPases Are Required for Activation of Jak/STAT Signaling by G Protein-Coupled Receptors , 2003, Molecular and Cellular Biology.
[26] L. Hodgson,et al. Melanoma cell migration to type IV collagen requires activation of NF-κB , 2003, Oncogene.
[27] Mina J Bissell,et al. The organizing principle: microenvironmental influences in the normal and malignant breast. , 2002, Differentiation; research in biological diversity.
[28] M. Rao,et al. Microarray analysis of selected genes in neural stem and progenitor cells , 2002, Journal of neurochemistry.
[29] Yukio Nakamura,et al. Small guanosine triphospatase RhoA and Rho-associated kinase as regulators of trophoblast migration. , 2002, The Journal of clinical endocrinology and metabolism.
[30] R. Treisman,et al. The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization. , 2002, Molecular biology of the cell.
[31] K. Jakobs,et al. Adhesiveness of human uterine epithelial RL95-2 cells to trophoblast: rho protein regulation. , 2002, Molecular human reproduction.
[32] Tony Pawson,et al. β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB , 2002, Cell.
[33] Ruedi Aebersold,et al. Quantitative proteomic analysis of Myc oncoprotein function , 2002, The EMBO journal.
[34] B. Kaina,et al. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters , 2002, British Journal of Cancer.
[35] A. Balmain,et al. High Activity of Serum Response Factor in the Mesenchymal Transition of Epithelial Tumor Cells Is Regulated by RhoA Signaling* , 2002, The Journal of Biological Chemistry.
[36] Yi Zheng,et al. RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion. , 2002, Gastroenterology.
[37] John G. Collard,et al. Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours , 2002, Nature.
[38] E. Sahai,et al. ROCK and Dia have opposing effects on adherens junctions downstream of Rho , 2002, Nature Cell Biology.
[39] R. Treisman,et al. LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics , 2002, The Journal of cell biology.
[40] P. Sánchez,et al. Gli and hedgehog in cancer: tumours, embryos and stem cells , 2002, Nature Reviews Cancer.
[41] M. Jo,et al. Cooperativity between the Ras-ERK and Rho-Rho Kinase Pathways in Urokinase-type Plasminogen Activator-stimulated Cell Migration* , 2002, The Journal of Biological Chemistry.
[42] Michael Karin,et al. NF-κB in cancer: from innocent bystander to major culprit , 2002, Nature Reviews Cancer.
[43] L. Van Aelst,et al. The role of Rho GTPases in disease development. , 2002, Gene.
[44] R. Mattingly,et al. High RhoA activity maintains the undifferentiated mesenchymal cell phenotype, whereas RhoA down-regulation by laminin-2 induces smooth muscle myogenesis , 2002, The Journal of cell biology.
[45] A. Nordheim,et al. Serum response factor is crucial for actin cytoskeletal organization and focal adhesion assembly in embryonic stem cells , 2002, The Journal of cell biology.
[46] A. Bosserhoff,et al. The transcriptional coactivator FHL2 transmits Rho signals from the cell membrane into the nucleus , 2002, The EMBO journal.
[47] H. Barth,et al. Role of Rac and Cdc42 in lysophosphatidic acid-mediated cyclo-oxygenase-2 gene expression , 2002 .
[48] J. Sturge,et al. N-WASP activation by a beta1-integrin-dependent mechanism supports PI3K-independent chemotaxis stimulated by urokinase-type plasminogen activator. , 2002, Journal of cell science.
[49] E. Sahai,et al. RHO–GTPases and cancer , 2002, Nature Reviews Cancer.
[50] D. Gingras,et al. Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes. , 2002, The Biochemical journal.
[51] B. Tran,et al. Endothelin-1 stimulates human colonic myofibroblast contraction and migration , 2002, Gut.
[52] D. Montell,et al. Paracrine Signaling through the JAK/STAT Pathway Activates Invasive Behavior of Ovarian Epithelial Cells in Drosophila , 2001, Cell.
[53] K. Nagata,et al. Coronary smooth muscle differentiation from proepicardial cells requires rhoA-mediated actin reorganization and p160 rho-kinase activity. , 2001, Developmental biology.
[54] A. Ridley,et al. Rho family proteins: coordinating cell responses. , 2001, Trends in cell biology.
[55] H. Clevers,et al. Tumor environment: a potent driving force in colorectal cancer? , 2001, Trends in molecular medicine.
[56] E. Rozengurt,et al. Cytotoxic Necrotizing Factor fromEscherichia coli Induces RhoA-Dependent Expression of the Cyclooxygenase-2 Gene , 2001, Infection and Immunity.
[57] I. Weissman,et al. Stem cells, cancer, and cancer stem cells , 2001, Nature.
[58] H. Clevers,et al. APC, Signal transduction and genetic instability in colorectal cancer , 2001, Nature Reviews Cancer.
[59] R. Perona,et al. Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation. , 2001, Molecular biology of the cell.
[60] R. Harvey,et al. Differential Binding of an SRF/NK-2/MEF2 Transcription Factor Complex in Normal Versus Neoplastic Smooth Muscle Tissues* , 2001, The Journal of Biological Chemistry.
[61] J. Settleman. Rac 'n Rho: the music that shapes a developing embryo. , 2001, Developmental cell.
[62] F. Watt. Stem cell fate and patterning in mammalian epidermis. , 2001, Current opinion in genetics & development.
[63] J. Soria,et al. Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. , 2001, Carcinogenesis.
[64] D. Bar-Sagi,et al. Rac1 mediates STAT3 activation by autocrine IL-6 , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[65] L. Dekker,et al. Sequential Activation of Rac-1, SEK-1/MKK-4, and Protein Kinase Cδ Is Required for Interleukin-6-induced STAT3 Ser-727 Phosphorylation and Transactivation* , 2001, The Journal of Biological Chemistry.
[66] Weiqun Li,et al. Differential Requirement for Rho Family GTPases in an Oncogenic Insulin-like Growth Factor-I Receptor-induced Cell Transformation* , 2001, The Journal of Biological Chemistry.
[67] R. Treisman,et al. Differential Usage of Signal Transduction Pathways Defines Two Types of Serum Response Factor Target Gene* , 2001, The Journal of Biological Chemistry.
[68] Maria Julia Marinissen,et al. Regulation of c-myc expression by PDGF through Rho GTPases , 2001, Nature Cell Biology.
[69] J. Taipale,et al. The Hedgehog and Wnt signalling pathways in cancer , 2001, Nature.
[70] David A. Williams,et al. Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[71] J. Lacal,et al. Rho signals to cell growth and apoptosis. , 2001, Cancer letters.
[72] A. Hall,et al. Rac Mediates Cytoskeletal Rearrangements and Increased Cell Motility Induced by Urokinase-Type Plasminogen Activator Receptor Binding to Vitronectin , 2001, The Journal of cell biology.
[73] J. Gutkind,et al. Regulation of gene expression by the small GTPase Rho through the ERK6 (p38γ) MAP kinase pathway , 2001 .
[74] L. Van Aelst,et al. Rho GTPases: signaling, migration, and invasion. , 2000, Experimental cell research.
[75] S. Scherer,et al. Small GTPase Rac1: structure, localization, and expression of the human gene. , 2000, Biochemical and biophysical research communications.
[76] D. Bar-Sagi,et al. Ras and Rho GTPases A Family Reunion , 2000, Cell.
[77] H. Vikis,et al. Regulation of STAT3 by direct binding to the Rac1 GTPase. , 2000, Science.
[78] L. Slice,et al. Differential regulation of COX-2 transcription by Ras- and Rho-family of GTPases. , 2000, Biochemical and biophysical research communications.
[79] E. Lengyel,et al. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b , 2000, Oncogene.
[80] F. Alt,et al. Cdc42 is required for PIP2-induced actin polymerization and early development but not for cell viability , 2000, Current Biology.
[81] P. Jones,et al. Regulation of urokinase receptor transcription by Ras- and Rho-family GTPases. , 2000, Biochemical and biophysical research communications.
[82] C. Preudhomme,et al. Nonrandom 4p13 rearrangements of the RhoH/TTF gene, encoding a GTP-binding protein, in non-Hodgkin's lymphoma and multiple myeloma , 2000, Oncogene.
[83] P. Jordan,et al. Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors , 1999, Oncogene.
[84] J. Turkson,et al. Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein , 1999, Molecular and Cellular Biology.
[85] C. Der,et al. Dependence of Dbl and Dbs Transformation on MEK and NF-κB Activation , 1999, Molecular and Cellular Biology.
[86] N. Sato,et al. Effect of mechanical strain on gastric cellular migration and proliferation during mucosal healing: role of Rho dependent and Rac dependent cytoskeletal reorganisation , 1999, Gut.
[87] E. Rozengurt,et al. Gα13 Stimulates Rho-dependent Activation of the Cyclooxygenase-2 Promoter* , 1999, The Journal of Biological Chemistry.
[88] C. Der,et al. Integration of Rac-dependent Regulation of Cyclin D1 Transcription through a Nuclear Factor-κB-dependent Pathway* , 1999, The Journal of Biological Chemistry.
[89] R. Scott,et al. Transformation blocks differentiation-induced inhibition of serum response factor interactions with serum response elements. , 1999, Cancer research.
[90] Richard Treisman,et al. Signal-Regulated Activation of Serum Response Factor Is Mediated by Changes in Actin Dynamics , 1999, Cell.
[91] B. Kaina,et al. Rho GTPases are over‐expressed in human tumors , 1999, International journal of cancer.
[92] R. Perona,et al. Activation of Serum Response Factor by RhoA Is Mediated by the Nuclear Factor-κB and C/EBP Transcription Factors* , 1999, The Journal of Biological Chemistry.
[93] L. Clayton,et al. A role for Rho-like GTPases in the polarisation of mouse eight-cell blastomeres. , 1999, Developmental biology.
[94] Kenji Nakamura,et al. Rac1 is required for the formation of three germ layers during gastrulation , 1998, Oncogene.
[95] R. Perona,et al. Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases* , 1998, The Journal of Biological Chemistry.
[96] L. Machesky,et al. Cytokinesis: IQGAPs find a function , 1998, Current Biology.
[97] L. Van Aelst,et al. Rho GTPases and signaling networks. , 1997, Genes & development.
[98] P. Fort,et al. Structure of the human ARHG locus encoding the Rho/Rac-like RhoG GTPase. , 1997, Genomics.
[99] E. Chono,et al. Expression of rac1 protein in the crypt-villus axis of rat small intestine: in reference to insulin action. , 1997, Biochemical and biophysical research communications.
[100] R. Bravo,et al. Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. , 1997, Genes & development.
[101] V. Ferrans,et al. rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation , 1996, Molecular and cellular biology.
[102] D. Montell,et al. Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis , 1996, The Journal of cell biology.
[103] H. Rui,et al. STAT5a activation mediates the epithelial to mesenchymal transition induced by oncogenic RhoA. , 2003, Molecular biology of the cell.
[104] Robert A. Weinberg,et al. Metastasis genes: A progression puzzle , 2002, Nature.
[105] J. Lacal,et al. Searching new targets for anticancer drug design: the families of Ras and Rho GTPases and their effectors. , 2001, Progress in nucleic acid research and molecular biology.