Evidence against prolactin stimulation of aldosterone in normal human subjects and patients with primary aldosteronism, including a patient with primary aldosteronism and a prolactin-producing pituitary microadenoma.

In addition to ACTH, another cranial factor, possibly prolactin, might stimulate aldosterone secretion. To evaluate this possibility, plasma prolactin concentration was determined in normal subjects and patients with primary aldosteronism during regular sodium diet and low sodium diet and was correlated with plasma aldosterone and cortisol concentration during 0200–0800 h circadian rhythm studies with plasma samples obtained every 20 min. Plasma prolactin and aldosterone concentrations exhibited a positive correlation in only one of three normal subjects during regular sodium diet and in two of four patients with primary aldosteronism during dexamethasone administration. Plasma prolactin and cortisol concentrations correlated positively with a similar frequency. Dexamethasone administration suppressed plasma prolactin concentration in three normal subjects and three of four patients with primary aldosteronism during regular sodium diet and one of two normal subjects during low sodium diet. Plasma prolacti...

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