An Alternative Approach to the Problem of Biomolecular Folding

After a brief overview that is focused on the importance of biological molecules like RNA and proteins, we present a model that can be used to predict the three‐dimensional structure of RNA sequences. An appropriate version of our model was first used in the description of polypeptide folding. These coarse‐graining models are based on a set of effective pair potentials that were extracted from experimental data. Such interaction potentials are then used as the main input of Monte Carlo simulations which are characterized by requiring a reasonable computer time, in comparison with other approaches. The resulting structures obtained from our method are clearly similar to the experimental ones.