Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks

[1]  K. Rhoades,et al.  Complement deposition and microglial activation in the outer retina in light-induced retinopathy: inhibition by a 5-HT1A agonist. , 2011, Investigative ophthalmology & visual science.

[2]  J. Provis,et al.  Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by microglia/macrophages is associated with focal photoreceptor degeneration. , 2011, Investigative ophthalmology & visual science.

[3]  Robyn H Guymer,et al.  Identification of urinary biomarkers for age-related macular degeneration. , 2011, Investigative ophthalmology & visual science.

[4]  J. Błasiak,et al.  The A Allele of the -576G>A polymorphism of the transferrin gene is associated with the increased risk of age-related macular degeneration in smokers. , 2011, The Tohoku journal of experimental medicine.

[5]  R. Braun,et al.  DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration , 2011, Nature.

[6]  R. Klein,et al.  Prevalence of age-related macular degeneration in the US population. , 2011, Archives of ophthalmology.

[7]  M. Güven,et al.  Glutathione S-Transferase M1, GSTT1 and GSTP1 Genetic Polymorphisms and the Risk of Age-Related Macular Degeneration , 2011, Ophthalmic Research.

[8]  D. Karczewicz,et al.  Different populations of circulating endothelial cells in patients with age-related macular degeneration: a novel insight into pathogenesis. , 2011, Investigative ophthalmology & visual science.

[9]  J. Jonas,et al.  Monocyte chemoattractant protein 1, intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 in exudative age-related macular degeneration. , 2010, Archives of ophthalmology.

[10]  K. Lashkari,et al.  Interferon gamma-inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration. , 2010, Investigative ophthalmology & visual science.

[11]  I. Campbell,et al.  Review: The chemokine receptor CXCR3 and its ligands CXCL9, CXCL10 and CXCL11 in neuroimmunity – a tale of conflict and conundrum , 2010, Neuropathology and applied neurobiology.

[12]  James A. Eddy,et al.  In silico models of cancer , 2010, Wiley interdisciplinary reviews. Systems biology and medicine.

[13]  A. Linneberg,et al.  Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study. , 2010, Investigative ophthalmology & visual science.

[14]  Christine A. Curcio,et al.  Abundant Lipid and Protein Components of Drusen , 2010, PloS one.

[15]  A. Verkerk,et al.  A New Strategy to Identify and Annotate Human RPE-Specific Gene Expression , 2010, PloS one.

[16]  Aaron Y. Lee,et al.  Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC) , 2010, Proceedings of the National Academy of Sciences.

[17]  Margaret A. Pericak-Vance,et al.  Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration , 2010, Proceedings of the National Academy of Sciences.

[18]  G. Abecasis,et al.  Transcriptome analysis and molecular signature of human retinal pigment epithelium , 2010, Human molecular genetics.

[19]  Don H. Anderson,et al.  The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited , 2010, Progress in retinal and eye research.

[20]  Eric N Brown,et al.  Complement, age-related macular degeneration and a vision of the future. , 2010, Archives of ophthalmology.

[21]  J. Hollyfield,et al.  Quantitative Proteomics: Comparison of the Macular Bruch Membrane/Choroid Complex from Age-related Macular Degeneration and Normal Eyes , 2010, Molecular & Cellular Proteomics.

[22]  K. Lashkari,et al.  Interferon – Inducible Protein-10 ( IP-10 ) and Eotaxin as Biomarkers in Age-Related Macular Degeneration , 2010 .

[23]  I. Chowers,et al.  Association of neovascular age-related macular degeneration with specific gene expression patterns in peripheral white blood cells. , 2010, Investigative Ophthalmology and Visual Science.

[24]  D. S. Mcleod,et al.  Low nitric oxide synthases (NOSs) in eyes with age-related macular degeneration (AMD). , 2010, Experimental eye research.

[25]  Aaron M. Newman,et al.  AutoSOME: a clustering method for identifying gene expression modules without prior knowledge of cluster number , 2010, BMC Bioinformatics.

[26]  M C Gillies,et al.  Bruch's membrane and choroidal macrophages in early and advanced age-related macular degeneration , 2009, British Journal of Ophthalmology.

[27]  A. Munnich,et al.  rs5888 Variant of SCARB1 Gene Is a Possible Susceptibility Factor for Age-Related Macular Degeneration , 2009, PloS one.

[28]  V. Perreau,et al.  Current and Future Applications of Transcriptomics for Discovery in CNS Disease and Injury , 2009, Neurosignals.

[29]  C. Sheridan,et al.  Expression of hypoxia-inducible factor−1α and −2α in human choroidal neovascular membranes , 2009, Graefe's Archive for Clinical and Experimental Ophthalmology.

[30]  T. Meitinger,et al.  Age‐related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene , 2009, Human mutation.

[31]  Jing Chen,et al.  ToppGene Suite for gene list enrichment analysis and candidate gene prioritization , 2009, Nucleic Acids Res..

[32]  D. Hu,et al.  Erythropoietin protects retinal pigment epithelial cells from oxidative damage. , 2009, Free radical biology & medicine.

[33]  Ben Lehner,et al.  Tissue specificity and the human protein interaction network , 2009, Molecular systems biology.

[34]  C. Barnstable,et al.  Bacterial endotoxin activates retinal pigment epithelial cells and induces their degeneration through IL-6 and IL-8 autocrine signaling. , 2009, Molecular immunology.

[35]  L. Lau,et al.  Functions and mechanisms of action of CCN matricellular proteins. , 2009, The international journal of biochemistry & cell biology.

[36]  R. Klein,et al.  Serum cystatin C level, kidney disease markers, and incidence of age-related macular degeneration: the Beaver Dam Eye Study. , 2009, Archives of ophthalmology.

[37]  Brad T. Sherman,et al.  Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists , 2008, Nucleic acids research.

[38]  Christian von Mering,et al.  STRING 8—a global view on proteins and their functional interactions in 630 organisms , 2008, Nucleic Acids Res..

[39]  M. Uusitupa,et al.  Single nucleotide polymorphisms of the tenomodulin gene (TNMD) in age-related macular degeneration , 2008, Molecular vision.

[40]  M. Daly,et al.  Variation near complement factor I is associated with risk of advanced AMD , 2009, European Journal of Human Genetics.

[41]  S. Ennis,et al.  Association between the SERPING1 gene and age-related macular degeneration: a two-stage case–control study , 2008, The Lancet.

[42]  G. Ying,et al.  Night vision symptoms and progression of age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial. , 2008, Ophthalmology.

[43]  G. Parmigiani,et al.  Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. , 2008, The New England journal of medicine.

[44]  R. Klein,et al.  Inflammation, complement factor h, and age-related macular degeneration: the Multi-ethnic Study of Atherosclerosis. , 2008, Ophthalmology.

[45]  A. Maminishkis,et al.  Control of chemokine gradients by the retinal pigment epithelium. , 2008, Investigative ophthalmology & visual science.

[46]  C. Nordgaard,et al.  Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration. , 2008, Investigative ophthalmology & visual science.

[47]  S. Vuk-Pavlović,et al.  Immune cells in the human choroid , 2008, British Journal of Ophthalmology.

[48]  F. Tsai,et al.  Pigment epithelium-derived factor gene Met72Thr polymorphism is associated with increased risk of wet age-related macular degeneration. , 2008, American journal of ophthalmology.

[49]  Dean P. Jones,et al.  Associations of plasma-soluble fas ligand with aging and age-related macular degeneration. , 2008, Investigative ophthalmology & visual science.

[50]  P. D'Amore,et al.  IGF2: epigenetic regulation and role in development and disease. , 2008, Cytokine & growth factor reviews.

[51]  A. Luff,et al.  Interleukin-8 promoter polymorphism −251A/T is a risk factor for age-related macular degeneration , 2008, British Journal of Ophthalmology.

[52]  A. Viola,et al.  Chemokines and their receptors: drug targets in immunity and inflammation. , 2008, Annual review of pharmacology and toxicology.

[53]  S. Sivaprasad,et al.  Plasma levels of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) in age-related macular degeneration , 2007, Eye.

[54]  W. Chao,et al.  IGF 2 : Epigenetic regulation and role in development and disease , 2008 .

[55]  P. Debré,et al.  CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration. , 2007, The Journal of clinical investigation.

[56]  Johanna M Seddon,et al.  Variation in complement factor 3 is associated with risk of age-related macular degeneration , 2007, Nature Genetics.

[57]  A. Hofman,et al.  C-reactive protein level and risk of aging macula disorder: The Rotterdam Study. , 2007, Archives of ophthalmology.

[58]  P. D. de Jong,et al.  Comparison of human retinal pigment epithelium gene expression in macula and periphery highlights potential topographic differences in Bruch's membrane. , 2007, Molecular vision.

[59]  Don H. Anderson,et al.  Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium/choroid. , 2007, Experimental eye research.

[60]  I. Deary,et al.  Complement C3 variant and the risk of age-related macular degeneration. , 2007, The New England journal of medicine.

[61]  S. Nelson,et al.  Celsius: a community resource for Affymetrix microarray data , 2007, Genome Biology.

[62]  P. Mitchell,et al.  Circulating inflammatory markers and hemostatic factors in age-related maculopathy: a population-based case-control study. , 2007, Investigative ophthalmology & visual science.

[63]  T. Sørensen,et al.  Heredity of small hard drusen in twins aged 20-46 years. , 2007, Investigative ophthalmology & visual science.

[64]  Ronald Klein,et al.  Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. , 2007, Ophthalmology.

[65]  I. Deary,et al.  Complement C 3 Variant and the Risk of Age-Related Macular Degeneration , 2007 .

[66]  N. Pfeiffer,et al.  Analysis of IgG antibody patterns against retinal antigens and antibodies to α-crystallin, GFAP, and α-enolase in sera of patients with “wet” age-related macular degeneration , 2007, Graefe's Archive for Clinical and Experimental Ophthalmology.

[67]  Chi Pui Pang,et al.  HTRA1 promoter polymorphism in wet age-related macular degeneration. , 2007, Science.

[68]  N. Camp,et al.  A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration , 2006, Science.

[69]  J. Escardo,et al.  VEGF polymorphisms are associated with neovascular age-related macular degeneration. , 2006, Human molecular genetics.

[70]  Eric P Hoffman,et al.  Secreted proteome profiling in human RPE cell cultures derived from donors with age related macular degeneration and age matched healthy donors. , 2006, Journal of proteome research.

[71]  Baitang Ning,et al.  Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[72]  C. Reilly,et al.  The proteome of central and peripheral retina with progression of age-related macular degeneration. , 2006, Investigative ophthalmology & visual science.

[73]  J. Mesirov,et al.  GenePattern 2.0 , 2006, Nature Genetics.

[74]  R. T. Smith,et al.  Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration , 2006, Nature Genetics.

[75]  C. Reilly,et al.  Proteomics of the retinal pigment epithelium reveals altered protein expression at progressive stages of age-related macular degeneration. , 2006, Investigative ophthalmology & visual science.

[76]  Don H. Anderson,et al.  Extended haplotypes in the complement factor H (CFH) and CFH‐related (CFHR) family of genes protect against age‐related macular degeneration: Characterization, ethnic distribution and evolutionary implications , 2006, Annals of medicine.

[77]  Don H. Anderson,et al.  Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts , 2006, Annals of medicine.

[78]  J. Gilbert,et al.  Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. , 2006, Investigative ophthalmology & visual science.

[79]  Don H. Anderson,et al.  Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications. , 2006, Annals of medicine.

[80]  L. Tamer,et al.  Glutathione s-transferase m1, t1, and p1 gene polymorphism in exudative age-related macular degeneration: a preliminary report. , 2006, European journal of ophthalmology.

[81]  L. Tamer,et al.  Glutathione S-Transferase M1, T1, and P1 Gene Polymorphism in Exudative Age-Related Macular Degeneration: A Preliminary Report , 2006, European journal of ophthalmology.

[82]  Don H. Anderson,et al.  Synaptic pathology, altered gene expression, and degeneration in photoreceptors impacted by drusen. , 2005, Investigative ophthalmology & visual science.

[83]  A. Swaroop,et al.  Biomarkers of cardiovascular disease as risk factors for age-related macular degeneration. , 2005, Ophthalmology.

[84]  K. Suzuma,et al.  EXPRESSION OF CONNECTIVE TISSUE GROWTH FACTOR AND ITS POTENTIAL ROLE IN CHOROIDAL NEOVASCULARIZATION , 2005, Retina.

[85]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[86]  Santa Jeremy Ono,et al.  Circulating anti‐retinal antibodies as immune markers in age‐related macular degeneration , 2005, Immunology.

[87]  G. Abecasis,et al.  Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. , 2005, Human molecular genetics.

[88]  B. Rosner,et al.  Progression of age-related macular degeneration: prospective assessment of C-reactive protein, interleukin 6, and other cardiovascular biomarkers. , 2005, Archives of ophthalmology.

[89]  R. T. Smith,et al.  A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[90]  C. Osmond,et al.  Association of HLA class I and class II polymorphisms with age-related macular degeneration. , 2005, Investigative ophthalmology & visual science.

[91]  A. Edwards,et al.  Complement Factor H Polymorphism and Age-Related Macular Degeneration , 2005, Science.

[92]  J. Ott,et al.  Complement Factor H Polymorphism in Age-Related Macular Degeneration , 2005, Science.

[93]  J. Gilbert,et al.  Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration , 2005, Science.

[94]  M. Parodi,et al.  MMP-9 microsatellite polymorphism and susceptibility to exudative form of age-related macular degeneration , 2005, Genetics in Medicine.

[95]  F. Sánchez‐Madrid,et al.  CD69 is an immunoregulatory molecule induced following activation. , 2005, Trends in immunology.

[96]  D. Ferrington,et al.  Declines in arrestin and rhodopsin in the macula with progression of age-related macular degeneration. , 2005, Investigative ophthalmology & visual science.

[97]  K. Palczewski,et al.  Microsomal glutathione S-transferase 1 in the retinal pigment epithelium: protection against oxidative stress and a potential role in aging. , 2005, Biochemistry.

[98]  D. Weeks,et al.  Susceptibility genes for age-related maculopathy on chromosome 10q26. , 2005, American journal of human genetics.

[99]  Lars G Fritsche,et al.  Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. , 2005, Human molecular genetics.

[100]  D. Koller,et al.  A module map showing conditional activity of expression modules in cancer , 2004, Nature Genetics.

[101]  Matthew Bogyo,et al.  Cathepsin V, a Novel and Potent Elastolytic Activity Expressed in Activated Macrophages* , 2004, Journal of Biological Chemistry.

[102]  E. Chew,et al.  The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age‐related macular degeneration , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[103]  V. Sheffield,et al.  Missense variations in the fibulin 5 gene and age-related macular degeneration. , 2004, The New England journal of medicine.

[104]  Robyn H Guymer,et al.  The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration. , 2004, Investigative ophthalmology & visual science.

[105]  M. Smith-Wheelock,et al.  Association of apolipoprotein E alleles with susceptibility to age-related macular degeneration in a large cohort from a single center. , 2004, Investigative ophthalmology & visual science.

[106]  J. Provis,et al.  Autoantibodies to retinal astrocytes associated with age-related macular degeneration , 2004, Graefe's Archive for Clinical and Experimental Ophthalmology.

[107]  M. Klein,et al.  Analysis of the ARMD1 locus: evidence that a mutation in HEMICENTIN-1 is associated with age-related macular degeneration in a large family. , 2003, Human molecular genetics.

[108]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[109]  M. Miyagi,et al.  Carboxyethylpyrrole Protein Adducts and Autoantibodies, Biomarkers for Age-related Macular Degeneration* , 2003, Journal of Biological Chemistry.

[110]  D. Hinton,et al.  A role for connective tissue growth factor in the pathogenesis of choroidal neovascularization. , 2003, Archives of ophthalmology.

[111]  A. Hackam,et al.  Identification of novel genes preferentially expressed in the retina using a custom human retina cDNA microarray. , 2003, Investigative ophthalmology & visual science.

[112]  John D. Storey,et al.  Statistical significance for genomewide studies , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[113]  N. D. Wangsa-Wirawan,et al.  Retinal Oxygen Fundamental and Clinical Aspects , 2003 .

[114]  B. Otlu,et al.  Serum leptin concentrations are decreased and correlated with disease severity in age-related macular degeneration: a preliminary study , 2003, Eye.

[115]  A. Hofman,et al.  The risk and natural course of age-related maculopathy: follow-up at 6 1/2 years in the Rotterdam study. , 2003, Archives of ophthalmology.

[116]  Terence P. Speed,et al.  A comparison of normalization methods for high density oligonucleotide array data based on variance and bias , 2003, Bioinform..

[117]  Richard M. Simon,et al.  A Paradigm for Class Prediction Using Gene Expression Profiles , 2003, J. Comput. Biol..

[118]  Gui-Shuang Ying,et al.  The role of apoptosis in age-related macular degeneration. , 2002, Archives of ophthalmology.

[119]  Masaru Miyagi,et al.  Drusen proteome analysis: An approach to the etiology of age-related macular degeneration , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[120]  Robert F Mullins,et al.  A role for local inflammation in the formation of drusen in the aging eye. , 2002, American journal of ophthalmology.

[121]  O. Volpert,et al.  Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration. , 2002, American journal of ophthalmology.

[122]  A. Nesburn,et al.  Alu DNA polymorphism in ACE gene is protective for age-related macular degeneration. , 2002, Biochemical and biophysical research communications.

[123]  R. Nitsch,et al.  CST3 genotype associated with exudative age related macular degeneration , 2002, The British journal of ophthalmology.

[124]  Robert F. Mullins,et al.  An Integrated Hypothesis That Considers Drusen as Biomarkers of Immune-Mediated Processes at the RPE-Bruch's Membrane Interface in Aging and Age-Related Macular Degeneration , 2001, Progress in Retinal and Eye Research.

[125]  S. Miller,et al.  Direct Activation of Innate and Antigen-Presenting Functions of Microglia following Infection with Theiler's Virus , 2001, Journal of Virology.

[126]  J. J. Wang,et al.  Risk factors for age-related maculopathy: the Visual Impairment Project. , 2001, Archives of ophthalmology.

[127]  F. Nestle,et al.  Cd1d is expressed on dermal dendritic cells and monocyte-derived dendritic cells. , 2001, The Journal of investigative dermatology.

[128]  T. Yoshikawa,et al.  Paraoxonase gene polymorphisms and plasma oxidized low-density lipoprotein level as possible risk factors for exudative age-related macular degeneration. , 2001, American journal of ophthalmology.

[129]  G. Lip,et al.  Age-related macular degeneration is associated with increased vascular endothelial growth factor, hemorheology and endothelial dysfunction. , 2001, Ophthalmology.

[130]  A Hofman,et al.  Risk factors for age-related macular degeneration: Pooled findings from three continents. , 2001, Ophthalmology.

[131]  Jennifer I. Lim,et al.  A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. , 2001, Archives of ophthalmology.

[132]  The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report Number 6. , 2001, American journal of ophthalmology.

[133]  S. Sonoda,et al.  Genetic association of manganese superoxide dismutase with exudative age-related macular degeneration. , 2000, American journal of ophthalmology.

[134]  M. Young,et al.  Factor H Binding to Bone Sialoprotein and Osteopontin Enables Tumor Cell Evasion of Complement-mediated Attack* , 2000, The Journal of Biological Chemistry.

[135]  L. V. Johnson,et al.  A potential role for immune complex pathogenesis in drusen formation. , 2000, Experimental eye research.

[136]  Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: Age-Related Eye Disease Study Report Number 3. , 2000, Ophthalmology.

[137]  S. Abe,et al.  Vascular endothelial growth factor and osteopontin in tumor biology. , 2000, Critical reviews in oncogenesis.

[138]  R. Frank,et al.  Antioxidant enzymes in the macular retinal pigment epithelium of eyes with neovascular age-related macular degeneration. , 1999, American journal of ophthalmology.

[139]  S. Seregard,et al.  Matrix metalloproteinases and metalloproteinase inhibitors in choroidal neovascular membranes. , 1998, Investigative ophthalmology & visual science.

[140]  A. Hofman,et al.  Genetic association of apolipoprotein E with age-related macular degeneration. , 1998, American journal of human genetics.

[141]  A. Munnich,et al.  The γ e4 allele of the apolipoprotein E gene as a potential protective factor for exudative age-related macular degeneration , 1998 .

[142]  J. Lupski,et al.  Mutation of the Stargardt disease gene (ABCR) in age-related macular degeneration. , 1997, Science.

[143]  P T de Jong,et al.  An international classification and grading system for age-related maculopathy and age-related macular degeneration , 1995 .

[144]  J. Banchereau,et al.  B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells , 1994, The Journal of experimental medicine.

[145]  R. Klein,et al.  Prevalence of age-related maculopathy. The Beaver Dam Eye Study. , 1992, Ophthalmology.

[146]  R. Klein,et al.  The Beaver Dam Eye Study. Retinopathy in adults with newly discovered and previously diagnosed diabetes mellitus. , 1992, Ophthalmology.

[147]  W. Foulds.  The choroidal circulation and retinal metabolism—An overview , 1990, Eye.

[148]  D. Newsome,et al.  Macular degeneration and elevated serum ceruloplasmin. , 1986, Investigative ophthalmology & visual science.

[149]  C. Graymore.  Biochemistry of the retina , 1966 .

[150]  J. Wishart.  Statistical tables , 2018, Global Education Monitoring Report.

[151]  R. A. Fisher,et al.  Statistical Tables for Biological, Agricultural and Medical Research , 1956 .