Analysis of HSV-1 and HSV-2 that cause herpes simplex with Apriori algorithm, decision tree, and support vector machine

The Herpes Simplex is a common fluid-intermitted disease that is common among not only adults but also children. Several symptoms include blisters and sores forming on infection sites that are mainly located in oral and genital body parts. The two main types of viral infection, commonly referred to as HSV-1 and HSV-2, are both part of the same Herpes Simplex Virus group (HSV), but they exhibit different characteristics in the main target of infection and the location of the infection sites. Normal cases of HSV-1 cause oral lesions and has less dangers of cross-generation infection when the female is pregnant, whereas HSV-2 cause genital lesions and usually is co-infected with human immunodeficiency virus type 1(HIV-1). Currently, no specific permanent vaccination is available for this disease and since it is chronic and can be transmitted as long as symptoms are present, the development of vaccination is significant at this stage. In order to provide further possibilities for vaccination development, we analyzed the genomes of HSV-1 and HSV-2 by using Apriori algorithm, Decision tree algorithm, and Support Vector Machine. Thus, we extracted results that showed the similarity and differences of the two genomes, mainly focusing on the prominent distribution of amino acids in each of the 3 categories we have chosen — dividing the genomes up in to 13, 17, and 19 windows. Through this, we have showed further potential in developing effective vaccination more specific to each type of Herpes Simplex.