The Trk family of neurotrophin receptors is downregulated in the lumbar spines of rats with congenital kyphoscoliosis

[1]  Rachel T. Uren,et al.  Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player , 2014, Front. Mol. Neurosci..

[2]  Y. Mikami,et al.  The P75 neurotrophin receptor regulates proliferation of the human MG63 osteoblast cell line. , 2014, Differentiation; research in biological diversity.

[3]  M. Hutchison Mice with a Conditional Deletion of the Neurotrophin Receptor TrkB Are Dwarfed, and Are Similar to Mice with a MAPK14 Deletion , 2013, PloS one.

[4]  S. Parent,et al.  Microarray expression profiling identifies genes with altered expression in Adolescent Idiopathic Scoliosis , 2013, European Spine Journal.

[5]  J. Weinstein,et al.  The influence of obesity on the outcome of treatment of lumbar disc herniation: analysis of the Spine Patient Outcomes Research Trial (SPORT). , 2013, The Journal of bone and joint surgery. American volume.

[6]  U. Mazurek,et al.  Vitamin D Receptor gene (VDR) transcripts in bone, cartilage, muscles and blood and microarray analysis of vitamin D responsive genes expression in paravertebral muscles of Juvenile and Adolescent Idiopathic Scoliosis patients , 2012, BMC Musculoskeletal Disorders.

[7]  Y. Ishii,et al.  The p75 neurotrophin receptor regulates MC3T3-E1 osteoblastic differentiation. , 2012, Differentiation; research in biological diversity.

[8]  W. Wu,et al.  Vitamin A Deficiency Induces Congenital Spinal Deformities in Rats , 2012, PloS one.

[9]  M. Rymaszewski,et al.  Central depletion of brain-derived neurotrophic factor in mice results in high bone mass and metabolic phenotype. , 2012, Endocrinology.

[10]  T. Kodama,et al.  Osteoprotection by semaphorin 3A , 2012, Nature.

[11]  P. Mantyh,et al.  The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A , 2011, Neuroscience.

[12]  P. Mantyh,et al.  Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers. , 2011, Bone.

[13]  P. Mantyh,et al.  Administration of a tropomyosin receptor kinase inhibitor attenuates sarcoma-induced nerve sprouting, neuroma formation and bone cancer pain , 2010, Molecular pain.

[14]  T. Takata,et al.  Brain-derived Neurotrophic Factor Stimulates Bone/Cementum-related Protein Gene Expression in Cementoblasts* , 2008, Journal of Biological Chemistry.

[15]  Jeffrey C. White,et al.  A nutritional model of late embryonic vitamin A deficiency produces defects in organogenesis at a high penetrance and reveals new roles for the vitamin in skeletal development. , 2008, Developmental biology.

[16]  N. Koibuchi,et al.  Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rats , 2008, Molecular and Cellular Biochemistry.

[17]  Seong-Jin Kim,et al.  TrkC binds to the bone morphogenetic protein type II receptor to suppress bone morphogenetic protein signaling. , 2007, Cancer research.

[18]  L. Reichardt,et al.  Neurotrophin-regulated signalling pathways , 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

[19]  R. Harland,et al.  Developmental Anomalies of the Cervical Spine in Patients With Fibrodysplasia Ossificans Progressiva Are Distinctly Different From Those in Patients With Klippel-Feil Syndrome: Clues From the BMP Signaling Pathway , 2005, Spine.

[20]  E. Huang,et al.  Trk receptors: roles in neuronal signal transduction. , 2003, Annual review of biochemistry.

[21]  M. Capecchi,et al.  Materials and Methods Som Text Figs. S1 to S4 Tables S1 and S2 References and Notes Hox10 and Hox11 Genes Are Required to Globally Pattern the Mammalian Skeleton , 2022 .

[22]  R. Nuttall,et al.  An evaluation of the performance of cDNA microarrays for detecting changes in global mRNA expression. , 2001, Nucleic acids research.

[23]  T. Yamashiro,et al.  Gene and protein expression of brain-derived neurotrophic factor and TrkB in bone and cartilage. , 2001, Bone.

[24]  H. Inoue,et al.  Expression of neurotrophins and their receptors (TRK) during fracture healing. , 2000, Bone.

[25]  Y. Barde,et al.  Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR , 1999, EMBO Journal.

[26]  M. Mehler,et al.  Development of Bone Morphogenetic Protein Receptors in the Nervous System and Possible Roles in Regulating trkC Expression , 1998, The Journal of Neuroscience.

[27]  H. Gong,et al.  p75NTR and Trk receptors are expressed in reciprocal patterns in a wide variety of non‐neural tissues during rat embryonic development, indicating independent receptor functions , 1998, The Journal of comparative neurology.

[28]  J. Massagué TGFβ Signaling: Receptors, Transducers, and Mad Proteins , 1996, Cell.

[29]  H. Thoenen,et al.  TrkA Tyrosine Residues Involved in NGF‐induced Neurite Outgrowth of PC12 Cells , 1995, The European journal of neuroscience.

[30]  C. Goodman,et al.  The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules , 1993, Cell.

[31]  M. Yamaguchi,et al.  Characterization of bone protein components with polyacrylamide gel electrophoresis: effects of zinc and hormones in tissue culture , 1992, Molecular and Cellular Biochemistry.

[32]  V. Rosen,et al.  Novel regulators of bone formation: molecular clones and activities. , 1988, Science.

[33]  H. Nikaido,et al.  Genetic analyses of the vertebral anomalies of the IS strain of rat and the development of a BN congenic line with the anomalies , 1982, Laboratory animals.

[34]  L. A. Goldstein,et al.  Classification and terminology of scoliosis. , 1973, Clinical orthopaedics and related research.

[35]  On Recent advances in the treatment of scoliosis in children , 2010 .

[36]  D. Kingsley,et al.  The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms. , 1994, Genes & development.