Vibrational spectroscopy and medicine: an alliance in the making

Both infrared (IR) and Raman spectroscopy are emerging as powerful probes of biomedically relevant properties of tissue and biological fluids. From tentative first steps, this field of endeavor is now beginning to mature as the central conceptual and technical issues come into focus. Using representative examples mainly from our own research, the aim of the present article is to provide the reader with a brief overview of progress to date.

[1]  R. Jonas,et al.  Near-infrared spectrophotometry of the brain in cardiovascular surgery. , 1998, The Thoracic and cardiovascular surgeon.

[2]  J L Luke,et al.  Raman chemical imaging: histopathology of inclusions in human breast tissue. , 1996, Analytical chemistry.

[3]  M. Manfait,et al.  ATR-FTIR spectroscopic investigation of imipenem-susceptible and -resistant Pseudomonas aeruginosa isogenic strains. , 1997, Biochemical and biophysical research communications.

[4]  E. Blout,et al.  Infrared Spectra of Tissues. , 1949, Science.

[5]  Dirk Boecker,et al.  Multicomponent assay for blood substrates in human sera and haemolysed blood by mid-infrared spectroscopy , 1998, Photonics West - Biomedical Optics.

[6]  Michael G. Sowa,et al.  Tissue viability by multispectral near infrared imaging: a fuzzy C-means clustering analysis , 1998, IEEE Transactions on Medical Imaging.

[7]  J. W. Hall,et al.  Near-infrared spectroscopic determination of serum total proteins, albumin, globulins, and urea. , 1993, Clinical biochemistry.

[8]  H. Mantsch,et al.  Infrared spectroscopy: a new frontier in medicine. , 1997, Biophysical chemistry.

[9]  J. W. Hall,et al.  Near-infrared spectrophotometry: a new dimension in clinical chemistry. , 1992, Clinical chemistry.

[10]  Trevor B. Posthumus,et al.  Visualization of cutaneous hemoglobin oxygenation and skin hydration using near‐infrared spectroscopic imaging , 2001, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[11]  M. Diem,et al.  Infrared spectroscopy of human tissue. V. Infrared spectroscopic studies of myeloid leukemia (ML-1) cells at different phases of the cell cycle. , 1999, Biospectroscopy.

[12]  B. Rigas,et al.  Cytologically normal cells from neoplastic cervical samples display extensive structural abnormalities on IR spectroscopy: implications for tumor biology. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Michael L. Wach,et al.  In vivo determination of the molecular composition of artery wall by intravascular Raman spectroscopy. , 2000, Analytical chemistry.

[14]  R A Shaw,et al.  Infrared spectroscopy of exfoliated cervical cell specimens. Proceed with caution. , 1999, Analytical and quantitative cytology and histology.

[15]  M. Manfait,et al.  ATR‐FTIR spectroscopic investigation of E. coli transconjugants β‐lactams‐resistance phenotype , 1997, FEBS letters.

[16]  J. Fish,et al.  Near infrared spectroscopic assessment of hemodynamic changes in the early post-burn period. , 2001, Burns : journal of the International Society for Burn Injuries.

[17]  D. Naumann,et al.  Classification and identification of bacteria by Fourier-transform infrared spectroscopy. , 1991, Journal of general microbiology.

[18]  Henry H. Mantsch,et al.  Molecular spectroscopy in biodiagnostics (from Hippocrates to Herschel and beyond) , 1995 .

[19]  R Summers,et al.  Towards non-invasive screening of skin lesions by near-infrared spectroscopy. , 2001, The Journal of investigative dermatology.

[20]  P H Watson,et al.  Beware of connective tissue proteins: assignment and implications of collagen absorptions in infrared spectra of human tissues. , 1995, Biochimica et biophysica acta.

[21]  K. Volka,et al.  Application of Molecular Spectroscopy in the Mid-Infrared Region to the Determination of Glucose and Cholesterol in Whole Blood and in Blood Serum , 1997 .

[22]  Dukor Rk,et al.  A new, non-destructive method for analysis of clinical samples with FT-IR microspectroscopy. Breast cancer tissue as an example. , 1998 .

[23]  D. Naumann,et al.  Simultaneous infections with different serogroups of Legionella pneumophila investigated by routine methods and Fourier transform infrared spectroscopy , 1988, Journal of clinical microbiology.

[24]  S A Goldstein,et al.  Spatial distribution of phosphate species in mature and newly generated Mammalian bone by hyperspectral Raman imaging. , 1999, Journal of biomedical optics.

[25]  R L Somorjai,et al.  Near‐optimal region selection for feature space reduction: novel preprocessing methods for classifying MR spectra , 1998, NMR in biomedicine.

[26]  R A Shaw,et al.  Quantitation of protein, creatinine, and urea in urine by near-infrared spectroscopy. , 1996, Clinical biochemistry.

[27]  Henry H. Mantsch,et al.  Discrimination and quantitation using IR spectra: novel methods for serum analysis and for cervical dysplasia screening , 1998, Photonics West - Biomedical Optics.

[28]  Michael Seibold,et al.  Evaluation of Phenotypic Markers for Selection and Identification of Candida dubliniensis , 2000, Journal of Clinical Microbiology.

[29]  I Itzkan,et al.  Reagentless blood analysis by near-infrared Raman spectroscopy. , 1999, Diabetes technology & therapeutics.

[30]  R A Shaw,et al.  Multianalyte Serum Analysis Using Mid-Infrared Spectroscopy , 1998, Annals of clinical biochemistry.

[31]  G M Oosta,et al.  Preliminary investigation of near-infrared spectroscopic measurements of urea, creatinine, glucose, protein, and ketone in urine. , 2001, Clinical biochemistry.

[32]  H. Bruining,et al.  Raman spectroscopic method for identification of clinically relevant microorganisms growing on solid culture medium. , 2000, Analytical chemistry.

[33]  H. Mantsch,et al.  Infrared spectra of basal cell carcinomas are distinct from non-tumor-bearing skin components. , 1999, The Journal of investigative dermatology.

[34]  M F Stranc,et al.  Assessment of tissue viability using near-infrared spectroscopy. , 1998, British journal of plastic surgery.

[35]  J. Welzel Optical coherence tomography in dermatology: a review , 2001, Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging.

[36]  J D Kruse-Jarres,et al.  Multivariate calibration for assays in clinical chemistry using attenuated total reflection infrared spectra of human blood plasma. , 1989, Analytical chemistry.

[37]  J. Roodenburg,et al.  In vivo detection of dysplastic tissue by Raman spectroscopy. , 2000, Analytical chemistry.

[38]  Brian C. Wilson,et al.  In vivo Near-infrared Raman Spectroscopy: Demonstration of Feasibility During Clinical Gastrointestinal Endoscopy¶ , 2000, Photochemistry and photobiology.

[39]  Harald Labischinski,et al.  Microbiological characterizations by FT-IR spectroscopy , 1991, Nature.

[40]  B. Rigas,et al.  Infrared spectroscopy of exfoliated human cervical cells: evidence of extensive structural changes during carcinogenesis. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[41]  D. Naumann,et al.  Classification and Identification of Enterococci: a Comparative Phenotypic, Genotypic, and Vibrational Spectroscopic Study , 2001, Journal of Clinical Microbiology.

[42]  Henry H. Mantsch,et al.  Quantitation of glucose and urea in whole blood by mid-infrared spectroscopy of dry films , 2002 .

[43]  Frank R. Burden,et al.  An Investigation into FTIR Spectroscopy as a Biodiagnostic Tool for Cervical Cancer , 1998 .

[44]  A. Mahadevan-Jansen,et al.  Near‐Infrared Raman Spectroscopy for In Vitro Detection of Cervical Precancers , 1998 .

[45]  K. C Schuster,et al.  FTIR SPECTROSCOPY APPLIED TO BACTERIAL CELLS AS A NOVEL METHOD FOR MONITORING COMPLEX BIOTECHNOLOGICAL PROCESSES , 1999 .

[46]  F. Jöbsis Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. , 1977, Science.

[47]  R L Somorjai,et al.  Classification of breast tumors by grade and steroid receptor status using pattern recognition analysis of infrared spectra. , 1999, Cancer detection and prevention.

[48]  Royston Goodacre,et al.  Rapid Differentiation of Closely RelatedCandida Species and Strains by Pyrolysis-Mass Spectrometry and Fourier Transform-Infrared Spectroscopy , 1998, Journal of Clinical Microbiology.

[49]  M. Feld,et al.  Multicomponent blood analysis by near-infrared Raman spectroscopy. , 1999, Applied optics.

[50]  R. Shaw,et al.  Comparison of infrared spectroscopic and fluorescence depolarization assays for fetal lung maturity. , 2000, American journal of obstetrics and gynecology.

[51]  H. M. Heise,et al.  Multivariate Calibration for the Determination of Analytes in Urine Using Mid-Infrared Attenuated Total Reflection Spectroscopy , 2001 .

[52]  D L WOERNLEY Infrared absorption curves for normal and neoplastic tissues and related biological substances. , 1952, Cancer research.

[53]  D H Kohn,et al.  Raman spectroscopic imaging markers for fatigue-related microdamage in bovine bone. , 2000, Analytical chemistry.

[54]  H. M. Heise,et al.  Multicomponent Assay for Blood Substrates in Human Plasma by Mid-Infrared Spectroscopy and its Evaluation for Clinical Analysis , 1994 .

[55]  Kevin H. Hazen,et al.  Measurement of glucose and other analytes in undiluted human serum with near-infrared transmission spectroscopy , 1998 .

[56]  J. Chalmers,et al.  Handbook of vibrational spectroscopy , 2002 .

[57]  Christopher J. Frank,et al.  Raman spectroscopy of normal and diseased human breast tissues. , 1995, Analytical chemistry.

[58]  W. Nelson,et al.  UV resonance Raman spectra of bacteria, bacterial spores, protoplasts and calcium dipicolinate , 1990 .