Application of time-gated CCD camera with image intensifier in contactless detection of absorbing inclusions buried in optically turbid medium which mimics local changes in oxygenation of the brain tissue

The near infrared spectroscopy may be implemented using various optoelectronic techniques, however, most of them do not allow to carry out measurements at short source-detector separation. We propose a method, based on time-gated intensified CCD camera, which allows for contactless measurements and can be carried out at short source-detector separation. This technique was tested on a phantom with absorbing inclusions buried in an optically turbid medium which mimics local changes in oxygenation of the brain tissue.

[1]  O W Witte,et al.  Bedside assessment of cerebral perfusion reductions in patients with acute ischaemic stroke by near-infrared spectroscopy and indocyanine green. , 2004, Journal of neurology, neurosurgery, and psychiatry.

[2]  Britton Chance,et al.  PHASE MEASUREMENT OF LIGHT ABSORPTION AND SCATTER IN HUMAN TISSUE , 1998 .

[3]  G. Litscher,et al.  Transcranial cerebral oximetry , 1997 .

[4]  Heidrun Wabnitz,et al.  Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance , 2005, NeuroImage.

[5]  A. Villringer,et al.  Time-resolved multidistance near-infrared spectroscopy of the adult head: intracerebral and extracerebral absorption changes from moments of distribution of times of flight of photons. , 2004, Applied optics.

[6]  Piotr Sawosz,et al.  Assessment of inflow and washout of indocyanine green in the adult human brain by monitoring of diffuse reflectance at large source-detector separation. , 2011, Journal of biomedical optics.

[7]  Piotr Sawosz,et al.  Optical system based on time-gated, intensified charge-coupled device camera for brain imaging studies. , 2010, Journal of biomedical optics.

[8]  R. Cubeddu,et al.  Functional tomography using a time-gated ICCD camera , 2011, Biomedical optics express.

[9]  A. Sorensen,et al.  Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation. , 2005, Journal of biomedical optics.

[10]  Davide Contini,et al.  Multichannel time-resolved tissue oximeter for functional imaging of the brain , 2006, IEEE Transactions on Instrumentation and Measurement.

[11]  Anders M. Dale,et al.  Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy , 2004, NeuroImage.

[12]  David A Boas,et al.  Time-gated optical system for depth-resolved functional brain imaging. , 2006, Journal of biomedical optics.

[13]  Alessandro Torricelli,et al.  Time-resolved reflectance at null source-detector separation: improving contrast and resolution in diffuse optical imaging. , 2005, Physical review letters.

[14]  H. Obrig,et al.  Time-resolved near-infrared spectroscopy and imaging of the adult human brain. , 2010, Advances in experimental medicine and biology.

[15]  A Tosi,et al.  Non-contact time-resolved diffuse reflectance imaging at null source-detector separation. , 2012, Optics express.

[16]  Toshio Yanagida,et al.  Noncontact backscatter-mode near-infrared time-resolved imaging system: Preliminary study for functional brain mapping. , 2006, Journal of biomedical optics.

[17]  P. Poulet,et al.  Detection of cortical activation with time-resolved diffuse optical methods. , 2005, Applied optics.

[18]  R. Cubeddu,et al.  Multi-channel time-resolved system for functional near infrared spectroscopy. , 2006, Optics express.

[19]  Piotr Sawosz,et al.  Application of a time-resolved optical brain imager for monitoring cerebral oxygenation during carotid surgery. , 2012, Journal of biomedical optics.

[20]  Peter Niederer,et al.  Noninvasive measurement of regional cerebral blood flow and regional cerebral blood volume by near-infrared spectroscopy and indocyanine green dye dilution , 2003, NeuroImage.

[21]  R. Maniewski,et al.  Time-resolved optical imager for assessment of cerebral oxygenation. , 2007, Journal of biomedical optics.

[22]  Alessandro Torricelli,et al.  Time-resolved optical imaging through turbid media using a fast data acquisition system based on a gated CCD camera , 2003 .

[23]  Hamid Dehghani,et al.  Retinotopic mapping of adult human visual cortex with high-density diffuse optical tomography , 2007, Proceedings of the National Academy of Sciences.

[24]  B. Chance,et al.  Quantitative brain tissue oximetry, phase spectroscopy and imaging the range of homeostasis in piglet brain. , 2003, Advances in experimental medicine and biology.

[25]  M. Kacprzak,et al.  Time-resolved imaging of fluorescent inclusions in optically turbid medium — phantom study , 2010 .

[26]  W. Kuebler,et al.  Noninvasive Measurement of Regional Cerebral Blood Flow by Near-Infrared Spectroscopy and Indocyanine Green , 1998, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[27]  Martin Wolf,et al.  Different Time Evolution of Oxyhemoglobin and Deoxyhemoglobin Concentration Changes in the Visual and Motor Cortices during Functional Stimulation: A Near-Infrared Spectroscopy Study , 2002, NeuroImage.

[28]  F. Martelli,et al.  Penetration depth of light re-emitted by a diffusive medium: theoretical and experimental investigation. , 2002, Physics in medicine and biology.