Optical Properties of Modified Nanorod Particles for Biomedical Sensing

In this paper, an analytical and numerical investigation for modified gold nanorod particles, operating in the visible and in the infrared regime is proposed. The modified particles consist in a core/shell structure (dielectric core/metallic shell) embedded in a dielectric environment. Their electromagnetic properties, in terms of extinction cross section (absorption and scattering) for both longitudinal and transverse modes excitation, are evaluated. In particular, new analytical models are developed, describing their resonant behavior. Good agreement among the analytical, numerical, and experimental results was achieved. Exploiting the obtained models, the nanoparticle sensitivity was studied. Analytical and full wave results validate the high sensitivity performances and the potential role of such structures to be used for sensing applications.

[1]  P. Nordlander,et al.  A Hybridization Model for the Plasmon Response of Complex Nanostructures , 2003, Science.

[2]  Jian Zhu,et al.  Effect of aspect ratio on the inter-surface plasmonic coupling of tubular gold nanoparticle , 2011 .

[3]  Audrey Moores,et al.  The plasmon band in noble metal nanoparticles: an introduction to theory and applications , 2006 .

[4]  Hao Hong,et al.  Applications of gold nanoparticles in cancer nanotechnology. , 2008, Nanotechnology, science and applications.

[5]  Chih-Yu Chao,et al.  Electrically controlled surface plasmon resonance frequency of gold nanorods , 2006 .

[6]  Michele Follen,et al.  Real-time vital optical imaging of precancer using anti-epidermal growth factor receptor antibodies conjugated to gold nanoparticles. , 2003, Cancer research.

[7]  Fei Le,et al.  Nanorice: a hybrid plasmonic nanostructure. , 2006, Nano letters.

[8]  M. Orrit,et al.  Optical detection of single non-absorbing molecules using the surface plasmon resonance of a gold nanorod. , 2012, Nature nanotechnology.

[9]  U. Chettiar,et al.  Internal homogenization: effective permittivity of a coated sphere. , 2012, Optics express.

[10]  M. El-Sayed,et al.  Gold and silver nanoparticles in sensing and imaging: sensitivity of plasmon response to size, shape, and metal composition. , 2006, The journal of physical chemistry. B.

[11]  Adam D. McFarland,et al.  A Nanoscale Optical Biosensor: Real-Time Immunoassay in Physiological Buffer Enabled by Improved Nanoparticle Adhesion , 2003 .

[12]  P. Jain,et al.  Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: applications in biological imaging and biomedicine. , 2006, The journal of physical chemistry. B.

[13]  R. Devan,et al.  Spray deposited localized surface plasmonic Au–ZnO nanocomposites for solar cell application , 2012 .

[14]  Shaoyun Yin,et al.  Specific Protein Detection in Multiprotein Coexisting Environment by Using LSPR Biosensor , 2010, IEEE Transactions on Nanotechnology.

[15]  Younan Xia,et al.  Gold Nanocages: Engineering Their Structure for Biomedical Applications , 2005 .

[16]  Harry A. Atwater,et al.  Local detection of electromagnetic energy transport below the diffraction limit in metal nanoparticle plasmon waveguides , 2003, Nature materials.

[17]  Nikolai G. Khlebtsov,et al.  Optical polarizability of metal nanoparticles and their biospheric conjugates , 2006, Saratov Fall Meeting.

[18]  R. W. Christy,et al.  Optical Constants of the Noble Metals , 1972 .

[19]  A. Glisson,et al.  Electromagnetic mixing formulas and applications , 2000, IEEE Antennas and Propagation Magazine.

[20]  Byoungho Lee,et al.  Plasmonic Nanostructures for Nano-Scale Bio-Sensing , 2011, Sensors.

[21]  Muthukumaran Packirisamy,et al.  Gold nanostructure-integrated silica-on-silicon waveguide for the detection of antibiotics in milk and milk products , 2012, Other Conferences.

[22]  F. Wu,et al.  Localized Resonance of Composite Core-Shell Nanospheres, Nanobars and Nanospherical Chains , 2011 .

[23]  J. Pendry,et al.  Playing Tricks with Light , 1999, Science.

[24]  Xiaohua Huang,et al.  Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: applications in oral cancer. , 2005, Nano letters.