Merging nano-genotoxicology with eco-genotoxicology: an integrated approach to determine interactive genotoxic and sub-lethal toxic effects of C(60) fullerenes and fluoranthene in marine mussels, Mytilus sp.

[1]  A. Jha,et al.  A multiple biomarker approach to investigate the effects of copper on the marine bivalve mollusc, Mytilus edulis. , 2011, Ecotoxicology and environmental safety.

[2]  J. Readman,et al.  Tissue-specific expression of p53 and ras genes in response to the environmental genotoxicant benzo(α)pyrene in marine mussels. , 2011, Environmental science & technology.

[3]  N. Taylor,et al.  Histopathology of mussels (Mytilus sp.) from the Tamar estuary, UK. , 2011, Marine environmental research.

[4]  P. Frickers,et al.  Integration of biochemical, histochemical and toxicogenomic indices for the assessment of health status of mussels from the Tamar Estuary, U.K. , 2011, Marine environmental research.

[5]  A. Jha,et al.  Hypoxia-induced oxidative DNA damage links with higher level biological effects including specific growth rate in common carp, Cyprinus carpio L. , 2011, Ecotoxicology.

[6]  A. Jha,et al.  Photoexcitation of Aqueous Suspensions of Titanium Dioxide Nanoparticles: An Electron Spin Resonance Spin Trapping Study of Potentially Oxidative Reactions , 2011, Photochemistry and photobiology.

[7]  G. Millward,et al.  Tissue-specific incorporation and genotoxicity of different forms of tritium in the marine mussel, Mytilus edulis. , 2011, Environmental pollution.

[8]  J. Oris,et al.  Suspended C60 nanoparticles protect against short-term UV and fluoranthene photo-induced toxicity, but cause long-term cellular damage in Daphnia magna. , 2010, Aquatic toxicology.

[9]  C. Tyler,et al.  Review: Do engineered nanoparticles pose a significant threat to the aquatic environment? , 2010, Critical reviews in toxicology.

[10]  R. Handy,et al.  Tissue Injury and Cellular Immune Responses to Cadmium Chloride Exposure in the Common Mussel Mytilus edulis: Modulation by Lipopolysaccharide , 2010, Archives of environmental contamination and toxicology.

[11]  D. Sheehan,et al.  Exposure of the blue mussel, Mytilus edulis, to gold nanoparticles and the pro-oxidant menadione. , 2010, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[12]  Thomas H Hutchinson,et al.  Uptake and biological responses to nano-Fe versus soluble FeCl3 in excised mussel gills , 2010, Analytical and bioanalytical chemistry.

[13]  Shigehisa Endoh,et al.  In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles. , 2009, Toxicology letters.

[14]  G. Bogdanovic,et al.  Effects of fullerenol C60(OH)24 on the frequency of micronuclei and chromosome aberrations in CHO-K1 cells. , 2009, Mutation research.

[15]  D. Carroll,et al.  Fullerene exposures with oysters: embryonic, adult, and cellular responses. , 2009, Environmental science & technology.

[16]  Malcolm B. Jones,et al.  Linking genotoxic responses with cytotoxic and behavioural or physiological consequences: differential sensitivity of echinoderms (Asterias rubens) and marine molluscs (Mytilus edulis). , 2009, Aquatic toxicology.

[17]  Nathalie Tufenkji,et al.  Characterizing manufactured nanoparticles in the environment: multimethod determination of particle sizes. , 2009, Environmental science & technology.

[18]  C. Hirsch,et al.  C60 fullerene: a powerful antioxidant or a damaging agent? The importance of an in-depth material characterization prior to toxicity assays. , 2009, Environmental pollution.

[19]  A. Jha,et al.  Contamination of bivalve haemolymph samples by adductor muscle components: implications for biomarker studies , 2009, Ecotoxicology.

[20]  A. Viarengo,et al.  Expression analysis of the molluscan p53 protein family mRNA in mussels (Mytilus spp.) exposed to organic contaminants. , 2009, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[21]  Markus Schulz,et al.  Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations--many questions, some answers. , 2009, Mutation research.

[22]  Laura Hodson,et al.  Approaches to safe nanotechnology; managing the health and safety concerns associated with engineered nanomaterials , 2009 .

[23]  A. Jha,et al.  Titanium dioxide induced cell damage: a proposed role of the carboxyl radical. , 2009, Mutation research.

[24]  P. Frickers,et al.  Lysosomal cytotoxicity of carbon nanoparticles in cells of the molluscan immune system: An in vitro study , 2009 .

[25]  Steffen Loft,et al.  Oxidatively Damaged DNA in Rats Exposed by Oral Gavage to C60 Fullerenes and Single-Walled Carbon Nanotubes , 2008, Environmental health perspectives.

[26]  J. Meadows,et al.  Pollution of Aquatic Ecosystems II: Hydrocarbons, Synthetic Organics, Radionuclides, Heavy Metals, Acids, and Thermal Pollution , 2009 .

[27]  S. Doak,et al.  NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. , 2009, Biomaterials.

[28]  P. M. Williams,et al.  Confounding experimental considerations in nanogenotoxicology. , 2009, Mutagenesis.

[29]  T. Hei,et al.  Genotoxic responses to titanium dioxide nanoparticles and fullerene in gpt delta transgenic MEF cells , 2009, Particle and Fibre Toxicology.

[30]  Keld Alstrup Jensen,et al.  In vivo biology and toxicology of fullerenes and their derivatives. , 2008, Basic & clinical pharmacology & toxicology.

[31]  Jamie R Lead,et al.  Manufactured nanoparticles: an overview of their chemistry, interactions and potential environmental implications. , 2008, The Science of the total environment.

[32]  Antonio Marcomini,et al.  Genotoxicity, cytotoxicity, and reactive oxygen species induced by single‐walled carbon nanotubes and C60 fullerenes in the FE1‐Muta™Mouse lung epithelial cells , 2008, Environmental and molecular mutagenesis.

[33]  Awadhesh N. Jha,et al.  Genotoxic and cytotoxic potential of titanium dioxide (TiO2) nanoparticles on fish cells in vitro , 2008, Ecotoxicology.

[34]  Robert L Tanguay,et al.  Fullerene C60 exposure elicits an oxidative stress response in embryonic zebrafish. , 2008, Toxicology and applied pharmacology.

[35]  Awadhesh N Jha,et al.  Ecotoxicological applications and significance of the comet assay. , 2008, Mutagenesis.

[36]  A. Boudou,et al.  Effects of dietary methylmercury on zebrafish skeletal muscle fibres. , 2008, Environmental toxicology and pharmacology.

[37]  Mark R Wiesner,et al.  Antibacterial activity of fullerene water suspensions (nC60) is not due to ROS-mediated damage. , 2008, Nano letters.

[38]  Awadhesh N Jha,et al.  Hydroxyl radicals (*OH) are associated with titanium dioxide (TiO(2)) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells. , 2008, Mutation research.

[39]  Mark Crane,et al.  The ecotoxicology and chemistry of manufactured nanoparticles , 2008, Ecotoxicology.

[40]  Nanna B. Hartmann,et al.  Toxicity and bioaccumulation of xenobiotic organic compounds in the presence of aqueous suspensions of aggregates of nano-C(60). , 2008, Aquatic toxicology.

[41]  V. Arlt,et al.  Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo : experiments with Hepatic Cytochrome P450 Reductase Null mice , 2008 .

[42]  Qasim Chaudhry,et al.  Engineered nanomaterials in soils and water: how do they behave and could they pose a risk to human health? , 2007, Nanomedicine.

[43]  M. Barucca,et al.  Oxidative and modulatory effects of trace metals on metabolism of polycyclic aromatic hydrocarbons in the Antarctic fish Trematomus bernacchii. , 2007, Aquatic toxicology.

[44]  V. Arlt,et al.  The 32P-postlabeling assay for DNA adducts , 2007, Nature Protocols.

[45]  D. Tran,et al.  Protective effects of selenium on mercury-induced DNA damage in mussel haemocytes. , 2007, Aquatic toxicology.

[46]  M. Moore,et al.  Do nanoparticles present ecotoxicological risks for the health of the aquatic environment? , 2006, Environment international.

[47]  L. Rasmussen,et al.  Influence of biotransformation on trophic transfer of the PAH, fluoranthene. , 2006, Aquatic toxicology.

[48]  Alok Dhawan,et al.  Stable colloidal dispersions of C60 fullerenes in water: evidence for genotoxicity. , 2006, Environmental science & technology.

[49]  Awadhesh N Jha,et al.  Reliable Comet assay measurements for detecting DNA damage induced by ionising radiation and chemicals. , 2006, Mutation research.

[50]  T. Bagnyukova,et al.  Temperature increase results in oxidative stress in goldfish tissues. 2. Antioxidant and associated enzymes. , 2006, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[51]  T. Bagnyukova,et al.  Temperature increase results in oxidative stress in goldfish tissues. 1. Indices of oxidative stress. , 2006, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[52]  Eva Oberdörster,et al.  Toxicity of an engineered nanoparticle (fullerene, C60) in two aquatic species, Daphnia and fathead minnow. , 2006, Marine environmental research.

[53]  M. Depledge,et al.  An evaluation of the relative sensitivity of two marine bivalve mollusc species using the Comet assay. , 2006, Marine environmental research.

[54]  A. Jha,et al.  Genotoxic, cytotoxic, developmental and survival effects of tritiated water in the early life stages of the marine mollusc, Mytilus edulis. , 2005, Aquatic toxicology.

[55]  G. Millward,et al.  Impact of low doses of tritium on the marine mussel, Mytilus edulis: genotoxic effects and tissue-specific bioconcentration. , 2005, Mutation research.

[56]  G. Oberdörster,et al.  Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles , 2005, Environmental health perspectives.

[57]  J. Rotchell,et al.  Conservation of cancer genes in the marine invertebrate Mytilus edulis. , 2005, Environmental science & technology.

[58]  I. Corsi,et al.  DNA adducts, benzo(a)pyrene monooxygenase activity, and lysosomal membrane stability in Mytilus galloprovincialis from different areas in Taranto coastal waters (Italy). , 2004, Environmental research.

[59]  C Minier,et al.  Seasonal variations of a battery of biomarkers and physiological indices for the mussel Mytilus galloprovincialis transplanted into the northwest Mediterranean Sea. , 2004, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

[60]  Michael T. Lotze,et al.  Inflammation and necrosis promote tumour growth , 2004, Nature Reviews Immunology.

[61]  E. Oberdörster.  Manufactured Nanomaterials (Fullerenes, C60) Induce Oxidative Stress in the Brain of Juvenile Largemouth Bass , 2004, Environmental health perspectives.

[62]  A. Anandraj,et al.  Correlations between metal uptake in the soft tissue of Perna perna and gill filament pathology after exposure to mercury. , 2002, Marine pollution bulletin.

[63]  S. Peña-Llopis,et al.  Impaired glutathione redox status is associated with decreased survival in two organophosphate-poisoned marine bivalves. , 2002, Chemosphere.

[64]  Maurizio Prato,et al.  Excited-State Properties of C60 Fullerene Derivatives , 2000 .

[65]  M. Depledge,et al.  Genotoxic, cytotoxic and developmental effects of tributyltin oxide (TBTO): an integrated approach to the evaluation of the relative sensitivities of two marine species. , 2000, Marine environmental research.

[66]  T. Burgeot,et al.  Enzymatic biomarker measurement and study of DNA adduct formation in benzo , 2000, Aquatic toxicology.

[67]  M. Depledge,et al.  Optimized RAPD analysis generates high-quality genomic DNA profiles at high annealing temperature. , 2000, BioTechniques.

[68]  D. Phillips,et al.  Polycyclic aromatic hydrocarbons in the diet. , 1999, Mutation research.

[69]  D. Phillips,et al.  Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols. , 1999, Mutagenesis.

[70]  L. Marnett.  Lipid peroxidation-DNA damage by malondialdehyde. , 1999, Mutation research.

[71]  G. Lotufo.  Bioaccumulation of sediment-associated fluoranthene in benthic copepods: uptake, elimination and biotransformation , 1998 .

[72]  A. Kettrup,et al.  Distribution of polycyclic aromatic hydrocarbons (PAHs) in pore water and sediment of a small aquatic ecosystem , 1998 .

[73]  J. Weinstein.  Fluoranthene-induced histological alterations in oysters, Crassostrea virginica: Seasonal field and laboratory studies , 1997 .

[74]  Y. M. Sin,et al.  Effects of Mercury and Lead on Tissue Glutathione of the Green Mussel, Perna viridis L. , 1997, Bulletin of environmental contamination and toxicology.

[75]  D. Dixon,et al.  Development of an in vivo genotoxicity assay using the marine worm Platynereis dumerilii (Polychaeta: Nereidae). , 1996, Mutation research.

[76]  S. Harayama,et al.  Interspecific variations in adhesive protein sequences of Mytilus edulis, M. galloprovincialis, and M. trossulus. , 1995, The Biological bulletin.

[77]  D. Lowe,et al.  Lysosomal membrane responses in the blood and digestive cells of mussels experimentally exposed to fluoranthene , 1995 .

[78]  E. Cavalieri,et al.  Central role of radical cations in metabolic activation of polycyclic aromatic hydrocarbons. , 1995, Xenobiotica; the fate of foreign compounds in biological systems.

[79]  R. Pipe,et al.  Effects of fluoranthene on the immunocompetence of the common marine mussel, Mytilus edulis , 1994 .

[80]  I. Sunila.  Acute histological responses of the gill of the mussel, Mytilus edulis, to exposure by environmental pollutants , 1988 .

[81]  M. Auffret.  Histopathological changes related to chemical contamination in Mytilus edulis from field and experimental conditions , 1988 .

[82]  D. Lowe,et al.  Mortality and quantitative aspects of storage cell utilization in mussels, Mytilus edulis, following exposure to diesel oil hydrocarbons☆ , 1987 .