In consultative committee for space data systems (CCSDS) file delivery protocol (CFDP) recommendation of reliable transmission, there are no detail transmission procedure and delay calculation of prompted negative acknowledge and asynchronous negative acknowledge models. CFDP is designed to provide data and storage management, story and forward, custody transfer and reliable end-to-end delivery over deep space characterized by huge latency, intermittent link, asymmetric bandwidth and big bit error rate (BER). Four reliable transmission models are analyzed and an expected file-delivery time is calculated with different trans-mission rates, numbers and sizes of packet data units, BERs and frequencies of external events, etc. By comparison of four CFDP models, the requirement of BER for typical missions in deep space is obtained and rules of choosing CFDP models under different uplink state informations are given, which provides references for protocol models selection, utilization and modification.