Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53
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Kaori Sasai | H. Katayama | S. Sen | B. Czerniak | J. Bondaruk | H. Kawai | Zhi-Min Yuan | F. Suzuki | R. Arlinghaus | S. Fujii
[1] H. Saya,et al. Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells , 2003, Cell.
[2] Hiroki Nagase,et al. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human , 2003, Nature Genetics.
[3] K. Jeang,et al. A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter , 2003, Nature Cell Biology.
[4] S. Sen,et al. Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle. , 2003, Cell motility and the cytoskeleton.
[5] K. Hui,et al. Aurora-A Kinase Interacting Protein (AIP), a Novel Negative Regulator of Human Aurora-A Kinase* , 2002, The Journal of Biological Chemistry.
[6] S. Volinia,et al. The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults , 2002, Nature.
[7] S. Murray,et al. The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response , 2002, Nature.
[8] Feng Jiang,et al. Amplification/overexpression of a mitotic kinase gene in human bladder cancer. , 2002, Journal of the National Cancer Institute.
[9] Young-Sun Lin,et al. Suppression of the STK15 oncogenic activity requires a transactivation‐independent p53 function , 2002, The EMBO journal.
[10] Roman Körner,et al. Human TPX2 is required for targeting Aurora-A kinase to the spindle , 2002, The Journal of cell biology.
[11] E. Nabel,et al. A growth factor‐dependent nuclear kinase phosphorylates p27Kip1 and regulates cell cycle progression , 2002, The EMBO journal.
[12] C. Allis,et al. Mitotic Phosphorylation of Histone H3: Spatio-Temporal Regulation by Mammalian Aurora Kinases , 2002, Molecular and Cellular Biology.
[13] H. Katayama,et al. Interaction and Feedback Regulation between STK15/BTAK/Aurora-A Kinase and Protein Phosphatase 1 through Mitotic Cell Division Cycle* , 2001, The Journal of Biological Chemistry.
[14] Y. Miyoshi,et al. Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers , 2001, International journal of cancer.
[15] R. Hay,et al. SUMO-1 Conjugation in Vivo Requires Both a Consensus Modification Motif and Nuclear Targeting* , 2001, The Journal of Biological Chemistry.
[16] R. Kraft,et al. COP9 signalosome‐specific phosphorylation targets p53 to degradation by the ubiquitin system , 2001, The EMBO journal.
[17] D. Woods,et al. Regulation of p53 function. , 2001, Experimental cell research.
[18] M. Hung,et al. Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells , 2001, Nature Cell Biology.
[19] Erich A. Nigg,et al. Cell division: Mitotic kinases as regulators of cell division and its checkpoints , 2001, Nature Reviews Molecular Cell Biology.
[20] A. Levine,et al. Surfing the p53 network , 2000, Nature.
[21] C. Maki,et al. The MDM2 RING-finger domain is required to promote p53 nuclear export , 2000, Nature Cell Biology.
[22] Y Taya,et al. The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites. , 2000, Genes & development.
[23] Hsiao-Huei Wu,et al. MDM2--master regulator of the p53 tumor suppressor protein. , 2000, Gene.
[24] B. Brinkley,et al. The centrosome-associated Aurora/Ipl-like kinase family. , 2000, Current topics in developmental biology.
[25] J. Levine,et al. Surfing the p53 network , 2000, Nature.
[26] J. Bischoff,et al. The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis. , 1999, Trends in cell biology.
[27] C. Prigent,et al. Aurora/Ipl1p-related kinases, a new oncogenic family of mitotic serine-threonine kinases. , 1999, Journal of cell science.
[28] C. Maki. Oligomerization Is Required for p53 to be Efficiently Ubiquitinated by MDM2* , 1999, The Journal of Biological Chemistry.
[29] H. Mori,et al. Centrosomal kinase AIK1 is overexpressed in invasive ductal carcinoma of the breast. , 1999, Cancer research.
[30] A. Cuddihy,et al. The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro , 1999, Oncogene.
[31] Y Taya,et al. DNA damage‐inducible phosphorylation of p53 at N‐terminal sites including a novel site, Ser20, requires tetramerization , 1999, The EMBO journal.
[32] Y Taya,et al. A role for ATR in the DNA damage-induced phosphorylation of p53. , 1999, Genes & development.
[33] Jian Kuang,et al. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation , 1998, Nature Genetics.
[34] K. Sakaguchi,et al. DNA damage activates p53 through a phosphorylation-acetylation cascade. , 1998, Genes & development.
[35] Brian Schryver,et al. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers , 1998, The EMBO journal.
[36] Yoichi Taya,et al. DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2 , 1997, Cell.
[37] H. Sakamoto,et al. Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53. , 1997, Biochemistry.
[38] S. Sen,et al. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[39] Stephen N. Jones,et al. Regulation of p53 stability by Mdm2 , 1997, Nature.
[40] S. Sen,et al. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines , 1997, Oncogene.
[41] G. Woude,et al. Abnormal Centrosome Amplification in the Absence of p53 , 1996, Science.
[42] N. Heisterkamp,et al. Inhibition of Bcr serine kinase by tyrosine phosphorylation , 1996, Molecular and cellular biology.
[43] P. Shaw,et al. Regulation of specific DNA binding by p53: evidence for a role for O-glycosylation and charged residues at the carboxy-terminus. , 1996, Oncogene.
[44] C. Prives,et al. Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases , 1995, Nature.
[45] D. Glover,et al. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles , 1995, Cell.
[46] A. Levine,et al. Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. , 1994, Genes & development.
[47] D. Botstein,et al. Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. , 1993, Genetics.
[48] L. Strong,et al. Spontaneous abnormalities in normal fibroblasts from patients with Li-Fraumeni cancer syndrome: aneuploidy and immortalization. , 1990, Cancer research.